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    Studies on Loading Salicylic Acid in Xerogel Films of Crosslinked Hyaluronic Acid.

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    During the last decades, salicylic acid (SA) and hyaluronic acid (HA) have been studiedfor a wide range of cosmetic and pharmaceutical applications. The current study investigated thedrug loading potential of SA in HA-based crosslinked hydrogel films using a post-loading (osmosis)method of the unmedicated xerogels from saturated aqueous solutions of salicylic acid over a rangeof pH values. The films were characterized with Fourier-transform infra-red spectroscopy (FT-IR) andultraviolet-visible (UV-Vis) spectrophotometry in order to elucidate the drug loading profile and thefilms’ integrity during the loading process. Additional studies on their weight loss (%), gel fraction(%), thickness increase (%) and swelling (%) were performed. Overall, the studies showed significantfilm disintegration at highly acidic and basic solutions. No drug loading occurred at neutral andbasic pH, possibly due to the anionic repulsion between SA and HA, whereas at, pH 2.1, the drugloading was promising and could be detected via UV-Vis analysis of the medicated solutions, withthe SA concentration in the xerogel films at 28% w/w