4,833 research outputs found

    Search for dark matter and other new phenomena in events with an energetic jet and large missing transverse momentum using the ATLAS detector

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    Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses proton-proton collision data corresponding to an integrated luminosity of 36.1 fbâ1at a centre-of-mass energy of 13 TeV collected in 2015 and 2016 with the ATLAS detector at the Large Hadron Collider. Events are required to have at least one jet with a transverse momentum above 250 GeV and no leptons (e or μ). Several signal regions are considered with increasing requirements on the missing transverse momentum above 250 GeV. Good agreement is observed between the number of events in data and Standard Model predictions. The results are translated into exclusion limits in models with pair-produced weakly interacting dark-matter candidates, large extra spatial dimensions, and supersymmetric particles in several compressed scenarios.[Figure not available: see fulltext.]

    Measurements of Higgs boson production and couplings in the four-lepton channel in pp collisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector

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    The final ATLAS Run 1 measurements of Higgs boson production and couplings in the decay channel H → ZZ∗ → l+l-l'+l'-, where l, l' = e or μ, are presented. These measurements were performed using pp collision data corresponding to integrated luminosities of 4.5 and 20.3 fb-1 at center-of-mass energies of 7 and 8 TeV, respectively, recorded with the ATLAS detector at the LHC. The H → ZZ∗ → 4l signal is observed with a significance of 8.1 standard deviations, with an expectation of 6.2 standard deviations, at mH = 125.36 GeV, the combined ATLAS measurement of the Higgs boson mass from the H → γγ and H → ZZ∗ → 4l channels. The production rate relative to the Standard Model expectation, the signal strength, is measured in four different production categories in the H → ZZ∗ → 4l channel. The measured signal strength, at this mass, and with all categories combined, is 1.44+0.40-0.33. The signal strength for Higgs boson production in gluon fusion or in association with tt or bb pairs is found to be 1.7+0.5-0.4, while the signal strength for vector-boson fusion combined with WH/ZH associated production is found to be 0.3+1.6-0.9

    Immunotherapy in endometrial cancer: new scenarios on the horizon

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    This extensive review summarizes clinical evidence on immunotherapy and targeted therapy currently available for endometrial cancer (EC) and reports the results of the clinical trials and ongoing studies. The research was carried out collecting preclinical and clinical findings using keywords such as immune environment, tumor infiltrating lymphocytes, programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, immune checkpoint inhibitors, anti-PD-1/PD-L1 antibodies and others’ on PubMed. Finally, we looked for the ongoing immunotherapy trials on ClinicalTrials.gov. EC is the fourth most common malignancy in women in developed countries. Despite medical and surgical treatments, survival has not improved in the last decade and death rates have increased for uterine cancer in women. Therefore, identification of clinically significant prognostic risk factors and formulation of new rational therapeutic regimens have great significance for enhancing the survival rate and improving the outcome in patients with advanced or metastatic disease. The identification of genetic alterations, including somatic mutations and microsatellite instability, and the definition of intracellular signaling pathways alterations that have a major role in in tumorigenesis is leading to the development of new therapeutic options for immunotherapy and targeted therapy

    Transcriptomic and genomic analysis provides new insights in molecular and genetic processes involved in zucchini ZYMV tolerance

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    Cucurbita pepo is highly susceptible to Zucchini yellow mosaic virus (ZYMV) and the resistance found in several wild species cannot be considered as complete or broad-spectrum resistance. In this study, a source of tolerance introgressed in C. pepo (381e) from C. moschata, in True French (TF) background, was investigated 12 days post-inoculation (DPI) at transcriptomic and genomic levels

    Digital Image Correlation analysis on the bone displacement during split crest: An ex vivo study

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    The split crest is an established surgical technique for horizontal bone augmentation. It allows to place implants of adequate diameter in sites where the bone would be too thin for the implantation. In this study, two split crest techniques (using threaded bone expanders or ultrasonic bone surgery) were performed ex vivo on bovine ribs, and dental implants were then inserted in the so prepared implantation sites. Digital image correlation was used to measure the bone external surface displacement throughout the surgical procedures. Both techniques provided an adequate bone volume for implant insertion, and no significant differences were highlighted regarding the displacement. However, bone accidental fracture only occurred during split crest with threaded bone expanders, suggesting differences in the internal strain distribution induced by the two technique

    Controversies in Surgical Staging of Endometrial Cancer

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    Endometrial cancer is the most common gynaecological malignancy and its incidence is increasing. In 1998, international federation of gynaecologists and obstetricians (FIGO) required a change from clinical to surgical staging in endometrial cancer, introducing pelvic and paraaortic lymphadenectomy. This staging requirement raised controversies around the importance of determining nodal status and impact of lymphadenectomy on outcomes. There is agreement about the prognostic value of lymphadenectomy, but its extent, therapeutic value, and benefits in terms of survival are still matter of debate, especially in early stages. Accurate preoperative risk stratification can guide to the appropriate type of surgery by selecting patients who benefit of lymphadenectomy. However, available preoperative and intraoperative investigations are not highly accurate methods to detect lymph nodes and a complete surgical staging remains the most precise method to evaluate extrauterine spread of the disease. Laparotomy has always been considered the standard approach for endometrial cancer surgical staging. Traditional and robotic-assisted laparoscopic techniques seem to provide equivalent results in terms of disease-free survival and overall survival compared to laparotomy. These minimally invasive approaches demonstrated additional benefits as shorter hospital stay, less use of pain killers, lower rate of complications and improved quality of life