3,534 research outputs found

    Robust seismic velocity change estimation using ambient noise recordings

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    We consider the problem of seismic velocity change estimation using ambient noise recordings. Motivated by [23] we study how the velocity change estimation is affected by seasonal fluctuations in the noise sources. More precisely, we consider a numerical model and introduce spatio-temporal seasonal fluctuations in the noise sources. We show that indeed, as pointed out in [23], the stretching method is affected by these fluctuations and produces misleading apparent velocity variations which reduce dramatically the signal to noise ratio of the method. We also show that these apparent velocity variations can be eliminated by an adequate normalization of the cross-correlation functions. Theoretically we expect our approach to work as long as the seasonal fluctuations in the noise sources are uniform, an assumption which holds for closely located seismic stations. We illustrate with numerical simulations and real measurements that the proposed normalization significantly improves the accuracy of the velocity change estimation

    Race/Ethnicity, Gender, Weight Status, and Colorectal Cancer Screening

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    Background. The literature on colorectal cancer (CRC) screening is contradictory regarding the impact of weight status on CRC screening. This study was intended to determine if CRC screening rates among 2005 National Health Interview Survey (NHIS) respondent racial/ethnic and gender subgroups were influenced by weight status. Methods. Univariable and multivariable logistic regression analyses were performed to determine if CRC screening use differed significantly among obese, overweight, and normal-weight individuals in race/ethnic and gender subgroups. Results. Multivariable analyses showed that CRC screening rates did not differ significantly for individuals within these subgroups who were obese or overweight as compared to their normal-weight peers. Conclusion. Weight status does not contribute to disparities in CRC screening in race/ethnicity and gender subgroups

    Two successful natural pregnancies in a patient with severe uterine prolapse: A case report

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    <p>Abstract</p> <p>Introduction</p> <p>Uterine prolapse is a common gynecologic condition that is rare during or before pregnancy. We report an exceptional case of two pregnancies in a totally prolapsed uterus.</p> <p>Case presentation</p> <p>A 36-year-old Caucasian woman with a history of uterine prolapse presented with pregnancy. A vaginal pessary was applied to keep her uterus inside the pelvis after manual reposition. The pessary was removed at the 24th week. The gravid uterus persisted in the abdominal cavity because of its increased volume.</p> <p>Conclusion</p> <p>Our case shows that pregnancy during uterine prolapse is possible and that careful assessment is required to prevent complications during delivery. According to our experience, an elective caesarean section near term could be the safest mode of delivery.</p

    A de novo 2.9 Mb interstitial deletion at 13q12.11 in a child with developmental delay accompanied by mild dysmorphic characteristics

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    Background: Proximal deletions in the 13q12.11 region are very rare. Much larger deletions including this region have been described and are associated with complex phenotypes of mental retardation, developmental delay and various others anomalies. Results: We report on a 3-year-old girl with a rare 2.9 Mb interstitial deletion at 13q12.11 due to a de novo unbalanced t(13;14) translocation. She had mild mental retardation and relatively mild dysmorphic features such as microcephaly, flat nasal bridge, moderate micrognathia and clinodactyly of 5th finger. Molecular karyotyping revealed a deletion on the long arm of chromosome 13 as involving sub-bands 13q12.11, a deletion of about 2.9 Mb. Discussion: The clinical application of array-CGH has made it possible to detect submicroscopical genomic rearrangements that are associated with varying phenotypes.The description of more patients with deletions of the 13q12.11 region will allow a more precise genotype-phenotype correlation

    Образ міста у творчості О. Іваненко (на матеріалі казки “Чарівна квітка”)

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    Авторка статті досліджує образ міста у творчості відомої письменниці ХХ ст. Оксани Іваненко. Автор робить спробу виокремити особливості творів, що характерні для її манери письма. Приділяється увага тематиці творів письменниці, портретній характеристиці її героїв. Дослідниця робить спробу схарактеризувати образ міста на матеріалі казок “Чарівна квітка”. “Місто боягузів” у казці “Чарівна квітка” О. Іваненко є точкою відліку в казковому часі, не має логіки у взаємозв’язку з дійсністю. Результатом дослідження є висновок про те, що письменниця досліджує процес становлення і розвитку дитини, вивчає особливості психології персонажів. Ключові слова: казка, логіка, образ, місто, тематика, реальність, персонажі.Автор статьи исследует образ города в творчестве известной писательницы ХХ века Оксаны Иваненко. Автор статьи делает попытку выделить особенности произведений, характерные ее письму. Уделяется внимание тематике произведений писательницы, портретной характеристике ее героев. Исследователь делает попытку охарактеризовать образ города на материале сказки “Волшебный цветок”. “Город боягузов” в сказке “Волшебный цветок” Оксаны Иваненко является точкой отсчета в сказочном времени, не имеет логики со взаимосвязью с действительностью. Результатом исследования является вывод о том, что писательница исследует процесс становления и развития юного читателя, изучает особенности психологии персонажей. Ключевые слова: сказка, логика, образ, город, тематика, реальность, персонажи.The author of the article investigates the figure of the city in the O. Ivanenko’s works, the famous writer of the XX th century. The author tries to define the peculiarities of her works. There are paid attentions to the portrait characteristics of the main characters in “Magic flower”, to the themes of her works. The investigator tries to characterise the figure of the city in the “Magic flower”. The “city of timorous people” in the “Magic flower” by O. Ivanenko is the beginning in the time of the tale, it does not have logic. This investigation proves that the writer investigates the process of the child’s growing and growing, studies the psychological peculiarities of the main characters. Keywords: tale, logic, figure, city, themes, reality, main characters

    Epigenetics as a mechanism driving polygenic clinical drug resistance

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    Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development. It is increasingly recognised that such epimutations may occur at a much higher frequency than gene mutation and therefore have a greater impact on selection of subpopulations of cells during tumour progression or acquisition of resistance to anticancer drugs. Although laboratory-based models of acquired resistance to anticancer agents tend to focus on specific genes or biochemical pathways, such 'one gene : one outcome' models may be an oversimplification of acquired resistance to treatment of cancer patients. Instead, clinical drug resistance may be due to changes in expression of a large number of genes that have a cumulative impact on chemosensitivity. Aberrant CpG island methylation of multiple genes occurring in a nonrandom manner during tumour development and during the acquisition of drug resistance provides a mechanism whereby expression of multiple genes could be affected simultaneously resulting in polygenic clinical drug resistance. If simultaneous epigenetic regulation of multiple genes is indeed a major driving force behind acquired resistance of patients' tumour to anticancer agents, this has important implications for biomarker studies of clinical outcome following chemotherapy and for clinical approaches designed to circumvent or modulate drug resistance
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