104 research outputs found

    Problematyka killer acquisitions w 艣wietle wyroku w sprawie Illumina/Grail przeciwko Komisji Europejskiej

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    Artyku艂 porusza problematyk臋 tzw. zab贸jczych przej臋膰 w 艣wietle orzeczenia Illumina/Grail v. Komisji. Autorzy artyku艂u wyja艣niaj膮 na czym polegaj膮 trudno艣ci zwi膮zane z tzw. zab贸jczymi przej臋ciami (przede wszystkim w kontek艣cie wydanego wyroku), opisuj膮 stan faktyczny analizowanej sprawy, przedstawiaj膮 najistotniejsze za艂o偶enia nowych wytycznych Komisji Europejskiej w przedmiocie stosowania art. 22 rozporz膮dzenia 139/2004, a tak偶e przedstawiaj膮 swoje krytyczne uwagi odno艣nie do orzeczenia zapad艂ego w sprawie Illumina/Grail v. Komisji. Celem artyku艂u jest zwr贸cenie uwagi na problematyk臋 tzw. zab贸jczych przej臋膰 w 艣wietle nowego podej艣cia Komisji Europejskiej i na potencjalne problemy, kt贸re przedsi臋biorcy mog膮 napotka膰 w tym zakresie

    Virtual Modelling and Simulation of a CNC Machine Feed Drive System

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    This paper deals with the virtual modelling and simulation of a complex CNC machine tool feed drive system. The first phase of the study was the modelling of a very complex structure of the feed drive which consists of many elements (position, velocity and current control regulators, actuators, mechanical transmission elements, etc.). All these elements have great influence on important parameters of the machine tool such as movement stability, positioning accuracy and dynamic stiffness. For the modelling of the system the Matlab-SIMULINK and Matlab-Sim Scape Toolbox software was used. The Matlab-Sim Scape Toolbox allowed us to use the complete CAD model of the geometry of the machine tool, automatically calculating the selected properties. The influence of changing and optimizing several feed drive parameters (position loop gain Kv, proportional gain Kp of the velocity controller, integral gain of velocity controller-Tn, electrical drive time constant Te, total moving mass m, sampling period Ts, etc.) on the positioning accuracy and the dynamic stiffness was simulated, tested and validated. The finished Matlab-Simulink and Sim Scape models were initially visualized in the Matlab program. They were very simplified, comparing with their later visualization in the Virtual Reality EON Studio program

    Machine Learning Successfully Detects Patients with COVID-19 Prior to PCR Results and Predicts Their Survival Based on Standard Laboratory Parameters in an Observational Study

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    Introduction: In the current COVID-19 pandemic, clinicians require a manageable set of decisive parameters that can be used to (i) rapidly identify SARS-CoV-2 positive patients, (ii) identify patients with a high risk of a fatal outcome on hospital admission, and (iii) recognize longitudinal warning signs of a possible fatal outcome. Methods: This comparative study was performed in 515 patients in the Maria Sk艂odowska-Curie Specialty Voivodeship Hospital in Zgierz, Poland. The study groups comprised 314 patients with COVID-like symptoms who tested negative and 201 patients who tested positive for SARS-CoV-2 infection; of the latter, 72 patients with COVID-19 died and 129 were released from hospital. Data on which we trained several machine learning (ML) models included clinical findings on admission and during hospitalization, symptoms, epidemiological risk, and reported comorbidities and medications. Results: We identified a set of eight on-admission parameters: white blood cells, antibody-synthesizing lymphocytes, ratios of basophils/lymphocytes, platelets/neutrophils, and monocytes/lymphocytes, procalcitonin, creatinine, and C-reactive protein. The medical decision tree built using these parameters differentiated between SARS-CoV-2 positive and negative patients with up to 90鈥100% accuracy. Patients with COVID-19 who on hospital admission were older, had higher procalcitonin, C-reactive protein, and troponin I levels together with lower hemoglobin and platelets/neutrophils ratio were found to be at highest risk of death from COVID-19. Furthermore, we identified longitudinal patterns in C-reactive protein, white blood cells, and D dimer that predicted the disease outcome. Conclusions: Our study provides sets of easily obtainable parameters that allow one to assess the status of a patient with SARS-CoV-2 infection, and the risk of a fatal disease outcome on hospital admission and during the course of the disease

    Acquired hemophilia A secondary to rheumatoid arthritis

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    Acquired hemophilia A (AHA) is a rare plasma diathesis. Unlike congenital hemophilia A, AHA occurs in both sexes and the incidence of the disease increases with age. It is caused by the production of autoantibodies against the coagulation factor VIII. AHA can be primary or secondary. The clinical course is characterized by a rapid development of symptoms, massive bleeding and high mortality. In the described case, a 69-year-old female was successfully treated for severe AHA with bypass-concentrate 鈥 recombinant activated factor VII and immunosuppressive therapy

    The stilbene and dibenzo[b,f]oxepine derivatives as anticancer compounds

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    In the present study, the synthesis and cytotoxic effect of six stilbenes and three oxepine derivatives against twocancerous鈥揌eLa and U87, and two normal鈥揈UFA30 and HEK293 cell lines has been reported. The results ofcytotoxic assay andflow cytometry analysis revealed that compounds 9-nitrobenzo[b]naphtho[1,2-f]oxepine(4), (E)-3,3鈥,4,4鈥,5,5鈥-hexamethoxystilbene (6) and 4-hydroxy-2鈥,4鈥-dinitrostilbene (8) were the most active andtheir interaction with tubulin (crystal structure from PDB) has been analyzed by computer molecular modeling.Molecular docking of these compounds on colchicine binding site of the tubulin indicates the interaction of (4),(6) and (8) with tubulin. The compound (4) could interact stronger with tubulin, relative to colchicine, however,with no selectivity of action against cancer and normal cells. Conversely, compounds (6) and (8) interact moreweakly with tubulin, relative to colchicine but they act more selectively towards cancerous versus normal celllines. Obtained results proved that the compounds that are the most active against cancerous cells operatethrough tubulin binding

    NetSquid, a NETwork Simulator for QUantum Information using Discrete events

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    In order to bring quantum networks into the real world, we would like to determine the requirements of quantum network protocols including the underlying quantum hardware. Because detailed architecture proposals are generally too complex for mathematical analysis, it is natural to employ numerical simulation. Here we introduce NetSquid, the NETwork Simulator for QUantum Information using Discrete events, a discrete-event based platform for simulating all aspects of quantum networks and modular quantum computing systems, ranging from the physical layer and its control plane up to the application level. We study several use cases to showcase NetSquid's power, including detailed physical layer simulations of repeater chains based on nitrogen vacancy centres in diamond as well as atomic ensembles. We also study the control plane of a quantum switch beyond its analytically known regime, and showcase NetSquid's ability to investigate large networks by simulating entanglement distribution over a chain of up to one thousand nodes.Comment: NetSquid is freely available at https://netsquid.org; refined main text section

    The bone microstructure from anterior cruciate ligament footprintsis similar after ligament reconstruction and does not affect long鈥憈ermoutcomes

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    Purpose The purpose of this study was to assess the quality of the bone tissue microstructure from the footprints of the anterior cruciate ligament (ACL) and its impact on late follow-up outcomes in patients who undergo anterior cruciate ligament reconstruction (ACLR). Methods The records of 26 patients diagnosed with a completely torn ACL who underwent ACLR were collected. During the surgery performed using the Felmet method, bone blocks from the native ACL footprints were collected. The primary measurements of the bone microstructure were made using a microtomographic scanner. In late follow-up examinations, a GNRB arthrometer was used. Results There was no significant difference in the bone microstructure assessed using micro-CT histomorphometric data according to the blood test results, plain radiographs, age or anthropometric data. There was no difference in the bone volume/total volume ratio or trabecular thickness in the area of the native ACL footprints. Routine preoperative examinations werenot relevant to the quality of the bone microstructure. The elapsed time from an ACL injury to surgery had no relevance to the results of arthrometry. Conclusion The similarities in the microstructure of bone blocks from ACL footprints from the femur and tibia allow the variable use of these blocks to stabilize grafts in the Felmet method. The bone microstructure is not dependent on the time from injury to surgery. Histomorphometric values of the structure of the femoral and tibial ACL footprints have no impact on the long-term stability of the operated knee joint. Trial registration The approval of the Bioethics Committee of the Silesian Medical Chamber in Katowice, Poland (resolution 16/2014) was given for this research

    Mechanical thrombectomy in acute stroke 鈥 Five years of experience in Poland

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    Objectives Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. Methods and results We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. Results Most of the CSCs (74%) were founded at University Hospitals and most (65.2%) work round the clock. In 78.3% of them, the working teams are composed of neurologists and neuro-radiologists. All CSCs perform CT and angio-CT before MT. In total 586 patients were subjected to MT and data from 531 of them were analyzed. Mean time laps from stroke onset to groin puncture was 250卤99min. 90.3% of the studied patients had MT within 6h from stroke onset; 59.3% of them were treated with IV rt-PA prior to MT; 15.1% had IA rt-PA during MT and 4.7% 鈥 emergent stenting of a large vessel. M1 of MCA was occluded in 47.8% of cases. The Solitaire device was used in 53% of cases. Successful recanalization (TICI2b鈥揟ICI3) was achieved in 64.6% of cases and 53.4% of patients did not experience hemorrhagic transformation. Clinical improvement on discharge was noticed in 53.7% of cases, futile recanalization 鈥 in 30.7%, mRS of 0鈥2 鈥 in 31.4% and mRS of 6 in 22% of cases. Conclusion Our results can help harmonize standards for MT in Poland according to international guidelines
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