6 research outputs found

    Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

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    Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

    The Examination of the Integration of Indigenous Knowledge in International Climate Discourse within the UNFCCC

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    This thesis examines how Indigenous knowledge is integrated into climate change legislation at the UN and UNFCCC levels, as well as how Indigenous knowledge is shared and who are the members of the Indigenous community doing the sharing. Through the analysis of policy relevant texts, the study reveals that the current approach to this integration can be characterized as extractive colonialism. The research employs discourse analysis and thematic coding to identify and analyze five central themes in three policy relevant texts. The findings highlight the historical entrenchment of the UN and UNFCCC in colonial histories, leading to a tendency to undervalue the intrinsic worth of Indigenous knowledge within Indigenous communities. The sharing of Indigenous knowledge is explored, emphasizing its complexity beyond the mere transfer of ideas. The research underlines the concern that knowledge sharing, when not approached with a genuine understanding of its significance and without considering individual perspectives, can become an extractive action. The profound value that Indigenous culture places on knowledge is emphasized, recognizing it not only as a repository of personal histories but also as a crucial aspect of identity. The study advocates for a more inclusive approach that acknowledges both the knowledge and its holders to facilitate a meaningful exchange of insights within Indigenous communities

    Microvascular changes in late-life schizophrenia and mood disorders: stereological assessment of capillary diameters in anterior cingulate cortex.

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    AIMS: Previous neuroimaging reports described morphological and functional abnormalities in anterior cingulate cortex (ACC) in schizophrenia and mood disorders. In earlier neuropathological studies, microvascular changes that could affect brain perfusion in these disorders have rarely been studied. Here, we analysed morphological parameters of capillaries in this area in elderly cases affected by these psychiatric disorders. METHODS: We analysed microvessel diameters in the dorsal and subgenual parts of the ACC in eight patients with schizophrenia, 10 patients with sporadic bipolar disorder, eight patients with sporadic major depression, and seven age- and gender-matched control cases on sections stained with modified Gallyas silver impregnation using a stereological counting approach. All individuals were drug-naïve or had received psychotropic medication for less than 6 months, and had no history of substance abuse. Statistical analysis included Kruskal-Wallis group comparisons with Bonferroni correction as well as multivariate regression models. RESULTS: Mean capillary diameter was significantly decreased in the dorsal and subgenual parts of areas 24 in bipolar and unipolar depression cases, both in layers III and V, whereas schizophrenia patients were comparable with controls. These differences persisted when controlling for age, local neuronal densities, and cortical thickness. In addition, cortical thickness was significantly smaller in both layers in schizophrenia patients. CONCLUSIONS: Our findings indicate that capillary diameters in bipolar and unipolar depression but not in schizophrenia are reduced in ACC. The significance of these findings is discussed in the light of the cytoarchitecture, brain metabolism and perfusion changes observed in ACC in mood disorders

    2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry

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    Pharmacophagy and pharmacophory: mechanisms of self-medication and disease prevention in the honeybee colony (Apis mellifera)

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    2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry

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