3,946 research outputs found

    Labour Migration From EaP Countries to the EU - Assessment of Costs and Benefits and Proposals for Better Labour Market Matching

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    It is reasonable to expect steady migratory flows from Eastern Parntership nations in the future, and that migration would be a desirable phenomenon (based on the so-far advantageous migratory flows from EaP nations). They cause no negative wage effects on native workers

    Chacterization of CU tube filled with Al alloy foam by means of X-ray computer tomography

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    Copper tubes filled with aluminium foams were prepared by directly foaming metal powder compacts inside them. Compressive behaviour and foam-shell interface, that characterizes mechanical properties of reinforced tubes, were investigated by means of variable focus X-ray computer tomography. Compression tests were performed on empty and filled samples at increasing deformation steps: at each stage the samples were observed by tomography. A geometric evaluation of porosity on 2D sections was performed by calculating, for each pore, its area, equivalent diameter and circularity

    Deployment of solar sails by joule effect: thermal analysis and experimental results

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    Space vehicles may be propelled by solar sails exploiting the radiation pressure coming from the sun and applied on their surfaces. This work deals with the adoption of Nickel-Titanium Shape Memory Alloy (SMA) elements in the sail deployment mechanism activated by the Joule Effect, i.e., using the same SMA elements as a resistance within suitable designed electrical circuits. Mathematical models were analyzed for the thermal analysis by implementing algorithms for the evaluation of the temperature trend depending on the design parameters. Several solar sail prototypes were built up and tested with different number, size, and arrangement of the SMA elements, as well as the type of the selected electrical circuit. The main parameters were discussed in the tested configurations and advantages discussed as well

    Malaria pigment hemozoin impairs gm-csf receptor expression and function by 4-hydroxynonenal

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    Malarial pigment hemozoin (HZ) generates the lipoperoxidation product 4-hydroxynonenal (4-HNE), which is known to cause dysregulation of the immune response in malaria. The inhibition of granulocyte macrophage colony-stimulating factor (GM-CSF)-dependent differentiation of dendritic cells (DC) by HZ and 4-HNE was previously described in vitro, and the GM-CSF receptor (GM-CSF R) was hypothesised to be a primary target of 4-HNE in monocytes. In this study, we show the functional impact of HZ on GM-CSF R in monocytes and monocyte-derived DC by (i) impairing GM-CSF binding by 50 ± 9% and 65 ± 14%, respectively (n = 3 for both cell types); (ii) decreasing the expression of GM-CSF R functional subunit (CD116) on monocyte’s surface by 36 ± 11% (n = 6) and in cell lysate by 58 ± 16% (n = 3); and (iii) binding of 4-HNE to distinct amino acid residues on CD116. The data suggest that defective DC differentiation in malaria is caused by GM-CSF R dysregulation and GM-CSF R modification by lipoperoxidation product 4-HNE via direct interaction with its CD116 subunit

    Outcome after Modified Maquet Procedure in dogs with unilateral cranial cruciate ligament rupture: Evaluation of recovery limb function by use of force plate gait analysis

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    Introduction Cranial cruciate ligament failure is one of the principal causes of canine lameness. Several surgical procedures were proposed to achieve joint stabilisation; among these, the Modified Maquet Procedure involves using a titanium foam wedge to achieve and maintain the tibial tuberosity advancement. The force-plate analysis provides to objectively assess normal and abnormal gait and the outcome of different surgical techniques. The study evaluates the outcome of limbs that underwent Modified Maquet Procedure using land-force plate analysis comparing the operated limb with its healthy contralateral one as a control. Materials and methods Thirty-five dogs with unilateral cranial cruciate ligament rupture were evaluated. Outcome after surgery was assessed by orthopaedic and radiographic evaluations and force plate gait analysis performed before surgery, at 15, 30 and 90 days after surgery. For objective comparison of ground reaction forces, data of operated limb were compared to contralateral limb on each time control and Symmetry Index at 90 days was determined. Healing radiographic signs, minor and major complication were reported. Results A significant improvement in ground reaction forces was reached in all the treated limbs between set time intervals. The median percentage increase in ground reaction forces was constant from 15 to 90 days, with a Symmetry Index >9 in 54.2% of patients suggesting a normal gait symmetry. A complete bone healing was noticed at 90 days follow-up radiographic assessment. We experienced three major (8.5%) and one minor (2.8%) complications. Conclusions To the Authors' knowledge, this is the first study in the veterinary literature that assessed outcomes of dogs undergoing Modified Maquet Procedure for the treatment of cranial cruciate ligament rupture using force plate gait analysis and healthy contralateral limb as a control group. Our results confirm that Modified Maquet Procedure is an effective method to stabilise the stifle joint

    The alkaline lamprophyres of the Dolomitic Area (Southern Alps, Italy): markers of the Late Triassic change from orogenic-like to anorogenic magmatism

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    We present the first complete petrological, geochemical and geochronological characterization of the oldest lamprophyric rocks in Italy, which crop out around Predazzo (Dolomitic Area), with the aim of deciphering their relationship with Triassic magmatic events across the whole of the Southern Alps. Their Mg# of between 37 and 70, together with their trace element contents, suggests that fractional crystallization was the main process responsible for their differentiation, together with small-scale mixing, as evidenced by some complex amphibole textures. Moreover, the occurrence of primary carbonate ocelli suggests an intimate association between the alkaline lamprophyric magmas and a carbonatitic melt. 40Ar/39Ar data show that the lamprophyres were emplaced at 219·22 ± 0·73 Ma (2σ; full systematic uncertainties), around 20 Myr after the high-K calc-alkaline to shoshonitic, short-lived, Ladinian (237–238 Ma) magmatic event of the Dolomitic Area. Their trace element and Sr–Nd isotopic signatures (87Sr/86Sri = 0·7033–0·7040; 143Nd/144Ndi = 0·51260–0·51265) are probably related to a garnet–amphibole-bearing lithosphere interacting with an asthenospheric component, significantly more depleted than the mantle source of the high-K calc-alkaline to shoshonitic magmas. These features suggest that the Predazzo lamprophyres belong to the same alkaline–carbonatitic magmatic event that intruded the mantle beneath the Southern Alps (e.g. Finero peridotite) between 190 and 225 Ma. In this scenario, the Predazzo lamprophyres cannot be considered as a late-stage pulse of the orogenic-like Ladinian magmatism of the Dolomitic Area, but most probably represent a petrological bridge to the opening of the Alpine Tethys
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