4 research outputs found

    Additional file 1: of Chronic sleep deprivation and gender-specific risk of depression in adolescents: a prospective population-based study

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    Table S1. Change in depression scores and cumulative sleep deprivation in adolescents by gender. Table S2. Sensitivity analyses of cumulative sleep deprivation and mean depression in adolescents by gender. Table S3. Complete-case analysis of cumulative sleep deprivation and mean change in depression in adolescents by gender. (DOCX 32 kb

    Mixed-Component SulfoneÔÇôSulfoxide Tagged Zinc IRMOFs: <i>In Situ</i> Ligand Oxidation, Carbon Dioxide, and Water Sorption Studies

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    Reported here are the syntheses and adsorption properties of a series of single- and mixed-component zinc IRMOFs derived from controlled ratios of sulfide and sulfone functionalized linear biphenyldicarboxylate (bpdc) ligands. During MOF synthesis the sulfide moieties undergo <i>in situ</i> oxidation, giving rise to sulfoxide functionalized ligands, which are incorporated to give mixed-component sulfoxideÔÇôsulfone functionalized MOFs. The single- and mixed-component systems all share the IRMOF-9 structure type as determined by a combination of single crystal and powder X-ray diffraction analyses. The functionalized IRMOF-9 series was investigated by N<sub>2</sub>, CO<sub>2</sub>, and water adsorption measurements. MOFs containing higher proportions of sulfoxide have slightly larger accessible surface areas and pore volumes, whereas MOFs containing a greater proportion of the sulfone functionality demonstrated higher CO<sub>2</sub> adsorption capacities, enthalpies of CO<sub>2</sub> adsorption, and CO<sub>2</sub>/N<sub>2</sub> selectivities. Water adsorption studies at 298 K showed the MOFs to have pore-filling steps starting around 0.4 <i>P/P</i><sub>0</sub>. In general, only small changes in water adsorption were observed with regards to ligand ratios in the mixed-component MOFs, suggesting that the location of the step is primarily determined by the pore size. A ligand-directed fine-tuning approach of changing alkyl chain length was demonstrated to give smaller more hydrophobic pores with better adsorption characteristics

    DataSheet_1_After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism.pdf

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    CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.</p

    DataSheet_2_After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism.docx

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    CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo, promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD+ salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.</p
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