3,063 research outputs found

    Langerhans cell sarcoma

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    Tumours derived from Langerhans cells (LCs) are divided into two main subgroups, according to the degree of cytological atypia and clinical aggressiveness: LC histiocytosis (LCH) and LC sarcoma (LCS). LCS is a high-grade neoplasm with obviously malignant cytologic features and the Langerhans cell phenotype, which is rare. Here the clinic-pathological of LCS will be discussed based on reported cases in the literature

    Nodal marginal zone lymphoma (NMZL)

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    Nodal marginal zone lymphoma (NMZL) is a primary nodal B-cell neoplasm that morphlogically resembles lymph nodes involved by MZL of extranodal or splenic types. Two clinicopathological forms of NMZL are recognized: adult type and pediatric-type. NMZLs show overlapping features with other types of MZL, but distinctive features as well. NMZL remains an enigmatic entity with accompanying difficulties in diagnosis and a lack of knowledge of prognosis and treatment

    DLBCL subtype: Extranodal lymphoma

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    The assessment of extranodal lymphomas poses considerable challenges to histopathologists in rutine work, because of the breadth of lymphoma subtypes, the variation in morphology, immunophenotype, genetics and clinical features of these entities, the difficulties in differential diagnosis, and the differential diagnosis, and the different clinical significance of lymphomas with primary versus secondary involvement of extranodal sites. DLBCL-NOS is the more frequent extranodal lymphoma subtype, w

    EBV positive DLBCL, NOS

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    Epstein-Barr virus positive DLBCL, NOS (EBV + DLBCL, NOS) occurs in apparently immunocompetent patients usually older than 50 years, which can also occur in younger patients and has a worse prognosis than EBV negative tumors. EBV + DLBCL, NOS has a broader morphological spectrum. Here the clinicopathological of EBV positive DLBCL will be discussed

    Primary DLBCL of the central nervous system (CNS)

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    Primary DLBCL of the central nervous system (DLBCL-CNS) is an aggressive B-cell neoplasm due in part to the intra-cerebral and/or intra-ocular location, and because a high percentage of cases are in the activated B cell like (ABC) subtype. Lymphoproliferative diseases of the central nervous system are rare, diagnostics and treatment are accordingly challenging. The special localization is related with a series of newly recognized genetic, genomic and immunologic features directing to the stron

    Monomorphic PTLD (B- and T/NK-cell types)

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    Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of transplantation, which represent a heterogeneous group of lymphoproliferative diseases and show a spectrum of clinical, morphologic, and molecular genetic features ranging from reactive polyclonal lesions to frank lymphomas. Monomorphic (M) PTLD fufill the criteria for one of the B-cell or T/NK cell neoplasms that are recognized in the immunocompetent host, which shows characteristic clinicopath

    Primary cutaneous DLBCL, leg type

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    Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL) leg type is an aggressive type of CBCL, characterized by skin lesions mainly on the legs and a predominance of diffuse sheets of centroblasts and immunoblasts. Given the poor prognosis, old age at onset, frequent relapses, and extracutaneous spread, PCDLBCL, leg type is a distinct type of cutaneous lyphoma. Here the clinicopathology of extranodal lymphomas will be discussed

    Polymorphic PTLD

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    Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of transplantation, which represent a heterogeneous group of lymphoproliferative diseases and show a spectrum of clinical, morphologic, and molecular genetic features ranging from reactive polyclonal lesions to frank lymphomas. Polymorphic(P) PTLD are composed of immunoblasts, plasma cells and small and intermediate-sized lymphoid cells that efface the architecture of lymph nodes or form destructiv

    Classical Hodgkin lymphoma type PTLD

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    Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of transplantation, which represent a heterogeneous group of lymphoproliferative diseases and show a spectrum of clinical, morphologic, and molecular genetic features ranging from reactive polyclonal lesions to frank lymphomas. Classical Hodgkin lymphoma (CHL) is the least common form of PTLD, which is almost always EBV-positive and should fufill the criteria for CHL
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