49 research outputs found

    CiteSee: Augmenting Citations in Scientific Papers with Persistent and Personalized Historical Context

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    When reading a scholarly article, inline citations help researchers contextualize the current article and discover relevant prior work. However, it can be challenging to prioritize and make sense of the hundreds of citations encountered during literature reviews. This paper introduces CiteSee, a paper reading tool that leverages a user's publishing, reading, and saving activities to provide personalized visual augmentations and context around citations. First, CiteSee connects the current paper to familiar contexts by surfacing known citations a user had cited or opened. Second, CiteSee helps users prioritize their exploration by highlighting relevant but unknown citations based on saving and reading history. We conducted a lab study that suggests CiteSee is significantly more effective for paper discovery than three baselines. A field deployment study shows CiteSee helps participants keep track of their explorations and leads to better situational awareness and increased paper discovery via inline citation when conducting real-world literature reviews

    Beyond Summarization: Designing AI Support for Real-World Expository Writing Tasks

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    Large language models have introduced exciting new opportunities and challenges in designing and developing new AI-assisted writing support tools. Recent work has shown that leveraging this new technology can transform writing in many scenarios such as ideation during creative writing, editing support, and summarization. However, AI-supported expository writing--including real-world tasks like scholars writing literature reviews or doctors writing progress notes--is relatively understudied. In this position paper, we argue that developing AI supports for expository writing has unique and exciting research challenges and can lead to high real-world impacts. We characterize expository writing as evidence-based and knowledge-generating: it contains summaries of external documents as well as new information or knowledge. It can be seen as the product of authors' sensemaking process over a set of source documents, and the interplay between reading, reflection, and writing opens up new opportunities for designing AI support. We sketch three components for AI support design and discuss considerations for future research.Comment: 3 pages, 1 figure, accepted by The Second Workshop on Intelligent and Interactive Writing Assistant

    Author Correction: Federated learning enables big data for rare cancer boundary detection.

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    10.1038/s41467-023-36188-7NATURE COMMUNICATIONS14

    New genetic loci link adipose and insulin biology to body fat distribution.

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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

    Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

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    Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)