44 research outputs found

    Programa de farmacovigilancia para IPS de baja complejidad

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    La farmacovigilancia se encuentra dirigida específicamente a los procesos relacionados con los medicamentos, con el fin de demostrar y poner en práctica los conocimientos adquiridos durante el tiempo del diplomado, de toda la carrera de Regencia de Farmacia, y con el propósito de identificar las destrezas y habilidades a la hora de presentarse una reacción alérgica de un medicamento en nuestro entorno de trabajo, poniendo en práctica las actividades propias de farmacovigilancia, para el buen uso adecuado de los medicamentos. Teniendo en cuenta que la farmacovigilancia es indispensable para la seguridad de los pacientes, en cualquier ámbito, donde el propósito es garantizar el uso seguro, efectivo y eficiente de los medicamentos para mejorar la calidad de vida de los usuarios y/o pacientes, en relación con la farmacoterapia. El programa de farmacovigilancia se encarga de recopilar la información acerca de las reacciones adversas y el mal uso de los medicamentos, que pueden ser sospechas probablemente por un mal procedimiento, igualmente se comunican posibles riesgos que afecten la salud, esta información es clave para tomar medidas de prevención ante el uso de los medicamentos. Las buenas prácticas de las farmacéuticas han tenido disputas de los gobiernos a nivel mundial, basándose en el cumplimiento de las funciones, quienes deben establecer una institución nacional de legislación farmacéutica, a la vez elegir un eje estratégico legal para el análisis de las reacciones y de los eventos adversos. (INVIMA, 2014) Palabras Claves: Reacciones adversas, Medicamento, Reacción alérgica, Seguridad, Uso adecuado de medicamentos, eventos adversos.Pharmacovigilance is specifically directed to processes related to medicines, in order to demonstrate and put into practice the knowledge acquired during the time of the diploma, of the entire Pharmacy Regency career, and with the purpose of identifying the skills and skills when an allergic reaction to a medication occurs in our work environment, putting into practice the activities of pharmacovigilance, for the proper use of medications. Taking into account that pharmacovigilance is essential for the safety of patients, in any field, where the purpose is to guarantee the safe, effective and efficient use of medicines to improve the quality of life of users and/or patients, in relation to with pharmacotherapy. The pharmacovigilance program is in charge of compiling information about adverse reactions and misuse of medications, which may be suspected, probably due to a bad procedure, also possible risks that affect health are communicated, this information is key to taking action of prevention before the use of medicines. Good pharmaceutical practices are the responsibility of national governments, which, in order to adequately fulfill these functions, must create a national drug regulatory body and designate an official center for the study of reactions and adverse events. (INVIMA, 2014) Keywords: Adverse reactions, Medication, Allergic reaction, Safety, Proper use of medications, adverse events. Keywords: Adverse reactions, Medications, Pharmacovigilance, Safety

    Post-thaw dilution of Rhamdia quelen sperm improves the reproductive success

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    The aim was to evaluate the effect of a post-thaw dilution of Rhamdia quelen sperm in 1.1% NaCl (325 mOsm kg-1; pH 7.6; 24 ◦C) solution on the quality and reproductive capacity. Sperm from eight males were cryopreservation in nitrogen vapor at 170 ◦C for 18 h in 0.25 mL straws in a freezing medium containing 5% fructose, 5% Powdered milk, and 10% methanol. The samples were thawed and post-thaw diluted (1:20) in NaCl solution or not (control). The higher spermatozoa velocities were observed in the post-thaw diluted samples (curvilinear (VCL) - 69 ± 11μm s-1; average path (VAP) - 45 ± 8 μm s-1; straight-line (VSL) - 43 ± 8 μm s-1) compared to the control (VCL - 47 ± 10 μm s-1; VAP - 31 ± 6 μm s-1; VSL - 30 ± 6 μm s-1). Greater straightness (STR), progression (PROG), and beat cross frequency (BCF) were observed in the post-thaw diluted samples (STR - 96 ± 7%; PROG - 666 ± 128 μm; BCF - 42 ± 2 Hz) than in control (STR - 95 ± 5%; PROG - 463 ± 92 μm; BCF - 40 ± 2 Hz). The strongly curled tail was the only morphology change that differ between the post-thaw diluted (5 ± 2%) and control (2 ± 1%). Membrane integrity, mitochondrial activity, and normal larvae rate were not different between treatments. Fertilization and hatching were higher in the post-thaw diluted sperm (93 ± 3%; 82± 9%) when compared to control samples (65 ± 13%; 55 ± 17%). Were used oocytes from one female, limiting these results. The post-thaw dilution improved the sperm kinetics and reproductive parameters. Thus, this methodology can be included in the sperm cryopreservation protocol for R. quelen

    Learning of Pharmacogenetics in human medicine students through PBL and ICTs

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    [EN] Objective: To describe the learning achievement after training in pharmacogenetics based on PBL and ICT and its persistence four years later in human medicine students of a public university in Peru.Materials and Methods: The knowledge of 160 students who received training on the pharmacogenetics of warfarin applying PBL and ICT was evaluated. The instrument was based on a clinical problem applied after training and 4 years later.Results: Results of the first evaluation indicated a good analytical resolution of the problem with argumentation in the genetic conditions of the patient. The four-year evaluation showed that 89% of the students continued at higher levels of learning.Conclusion: It was shown that the use of a meaningful learning methodology with PBL and ICT can make knowledge last and serve in the future for decision-making in the selection of medication.Placencia Medina, MD.; Silva Valencia, J.; Garcia Bustamante, C.; Villarreal Valerio, JA.; Pando Álvarez, R.; Malca Casavilca, M.; Contreras Pizarro, CH. (2022). Learning of Pharmacogenetics in human medicine students through PBL and ICTs. En 8th International Conference on Higher Education Advances (HEAd'22). Editorial Universitat Politècnica de València. 21-28. https://doi.org/10.4995/HEAd22.2022.14674212

    Amor, empatía y conductas prosociales: una reflexión interdisciplinaria

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    This book presents, through reflection, the relevance, timeliness and necessity of love, empathy and prosocial behaviors within the framework of the professional and disciplinary work of the authors. The reader will be able to find here what these professionals, academics and intellectuals think and feel about it. Let the reader know that it was not a simple writing project, maybe because of the invitation to think about oneself, maybe because of the presence of the concept of "love" in the academy, or maybe, because we are not so accustomed to putting in the first person the reflection turned from what we relate to day by day. May this text be the excuse to continue to reflect on the role of love, empathy and prosocial behavior in a world that sometimes shows great desolation. May these unknotted reflections allow us to understand and resignify, learn and continue.PublishedEste libro expone, por la vía de la reflexión, la pertinencia, actualidad y necesidad del amor, la empatía y las conductas prosociales en el marco del quehacer profesional y disciplinar de los autores. El lector podrá encontrar aquí lo que esos profesionales, académicos e intelectuales piensan y sienten al respecto. Sepa el lector que no fue un proyecto de escritura sencillo, quizá por la invitación a pensar sobre sí, quizá por la presencia del concepto “amor” en la academia, o quizá, simplemente, porque no estamos tan acostumbrados a poner en primera persona la reflexión devenida de aquello con lo que día a día nos relacionamos. Que sea este texto la excusa para continuar reflexionando sobre el papel del amor, la empatía y las conductas prosociales en un mundo que a veces muestra gran desolación. Que estas reflexiones des-anudadas permitan comprender y resignificar, aprender y continuar

    Pharmaceutical pollution of the world's rivers

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    Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world's rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals

    Pharmaceutical pollution of the world's rivers

    Get PDF
    Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world's rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals

    Post-thaw dilution of Rhamdia quelen sperm improves the reproductive success

    No full text
    The aim was to evaluate the effect of a post-thaw dilution of Rhamdia quelen sperm in 1.1% NaCl (325 mOsm kg(-1); pH 7.6; 24 degrees C) solution on the quality and reproductive capacity. Sperm from eight males were cryopreservation in nitrogen vapor at -170 degrees C for 18 h in 0.25 mL straws in a freezing medium containing 5% fructose, 5% Powdered milk, and 10% methanol. The samples were thawed and post-thaw diluted (1:20) in NaCl solution or not (control). The higher spermatozoa velocities were observed in the post-thaw diluted samples (curvilinear (VCL) -69 +/- 11 pm s(-1); average path (VAP) -45 +/- 8 pm s(-1); straight-line (VSL) -43 +/- 8 pm s(-1)) compared to the control (VCL -47 +/- 10 pm s(-1); VAP -31 +/- 6 pm s(-1); VSL -30 +/- 6 pm s(-1)). Greater straightness (STR), progression (PROG), and beat cross frequency (BCF) were observed in the post-thaw diluted samples (STR -96 +/- 7%; PROG -666 +/- 128 pm; BCF -42 +/- 2 Hz) than in control (STR -95 +/- 5%; PROG -463 +/- 92 pm; BCF -40 +/- 2 Hz). The strongly curled tail was the only morphology change that differ between the post-thaw diluted (5 +/- 2%) and control (2 +/- 1%). Membrane integrity, mitochondrial activity, and normal larvae rate were not different between treatments. Fertilization and hatching were higher in the post-thaw diluted sperm (93 +/- 3%; 82 +/- 9%) when compared to control samples (65 +/- 13%; 55 +/- 17%). Were used oocytes from one female, limiting these results. The post-thaw dilution improved the sperm kinetics and reproductive parameters. Thus, this methodology can be included in the sperm cryopreservation protocol for R. quelen

    The use of differential separation and density gradient with AllGrad 90% after thawing improves the sperm quality of South American catfish (Rhamdia quelen)

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    The use of technologies in assisted reproduction, such as the use of centrifugation, has been reported as a tool that allows separating the best portion of sperm from cryopreserved milt. The main of this work was to compare two separation techniques, differential and density gradient, on thawed Rhamdia quelen milt, based on sperm functionality and fertilization capacity. Three treatments were compared: control, differential centrifugation or pelletization (T1), and density gradient centrifugation (T2). Motility percentage was better for differential (42.58 ± 6.50%) than for the control treatment (32.44 ± 6.03%). Membrane integrity and kinetic parameters was not different between treatments. The presence of normal sperm was higher in T2 treatment (13.55 ± 5.82%) when compared to the control (10.72 ± 3.53%) and T1 (3.97 ± 1.95%). There was a lower rate of morphological tail damage in the T1 (26.91 ± 7.13%) treatment compared to the T2 (37.48 ± 10.81%) and control (45.88 ± 4.84%). For the head morphologies, the lowest percentages were for the control (35.72 ± 5.89%) and T2 (4.89 ± 14.94%) treatments compared to the T1 treatment (62.59 ± 9.67%). In the MTT (3- (4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) test (AU/100 million sptz), the centrifuged treatments resulted in values of 1.58 ± 0.79 (T1) and 2.02 ± 1.88 (T2), better than the treatment control (0.20 ± 0.08). Likewise, the fertilization and hatching rates, respectly, were better for the T1 (76.68 ± 15.22% and 54.62 ± 17.39%) and T2 (69.85 ± 17.85% and 50.87 ± 20.59%) treatments, than the control treatment (40.03 ± 11.67% and 24.14 ± 13.97%). The comparison of differential centrifugation with density gradient centrifugation was carried out for the first time with cryopreserved milt of R. quelen. In summary, both centrifugation techniques proved to be efficient in obtaining a better portion of functional sperm from thawed milt. This is based on the high rates of embryonic survival and hatching obtained after both differential and density gradient separation

    Conviviendo en armonía con las TIC: una táctica para consolidar las relaciones interpersonales en estudiantes de la Institución educativa San Pedro Claver

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    Este trabajo investigativo surge de la necesidad de mejorar un problema de convivencia escolar que se evidencia en la Institución Educativa San Pedro Claver, ubicada en el municipio de Puerto Tejada, departamento del Cauca, cuya población estudiantil pertenece a los estratos 1 y 2. Es por esta razón que desde nuestro que hacer docente consideramos pertinente elaborar y poner en marcha una estrategia, innovadora y dinámica que antes de aplicar sanciones y correctivos, permita orientar de manera activa y participativa, en este sentido vemos las TIC como nuestras mejores aliadas para emprender esta iniciativa, ya que ofrecen un abanico de recursos educativos digitales adecuadas para lograr motivar a nuestros estudiantes a trabajar por una sana convivencia. El grupo seleccionado para implementar la propuesta está constituido por 38 estudiantes del grado 7- D, son 25 niños y 13 niñas, su edad promedio es de 10 a 13 años, son solidarios, en algunos estudiantes se evidencia un alto porcentaje de situaciones conflictivas, registrándose la poca aceptación de normas establecidas por la institución, en el pacto de convivencia. Esta experiencia se dirigió a partir del enfoque cualitativo a través del modelo de investigación acción pedagógica, comprendió 3 fases: diagnostico, diseño e implementación y evaluación. Como recurso digital se ha implementado una wiki escolar digital como espacio de reflexión, participación y comunicación frente a las relaciones interpersonales que afectan la convivencia en el contexto escolar, se puede decir que ha resultado un gran acierto, a pesar de que el tiempo fue muy limitado para desarrollar a cabalidad cada una de las actividades, en lo que se logró adelantarse pudo evidenciar la gran aceptación y gusto de los estudiantes por el trabajo en la herramienta creada.MaestríaMagister en Recursos Digitales Aplicados a la Educació

    <p>The use of differential separation and density gradient with AllGrad 90% after thawing improves the sperm quality of South American catfish (Rhamdia quelen)</p>

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    The use of technologies in assisted reproduction, such as the use of centrifugation, has been reported as a tool that allows separating the best portion of sperm from cryopreserved milt. The main of this work was to compare two separation techniques, differential and density gradient, on thawed Rhamdia quelen milt, based on sperm functionality and fertilization capacity. Three treatments were compared: control, differential centrifugation or pelletization (T1), and density gradient centrifugation (T2). Motility percentage was better for differential (42.58 +/- 6.50%) than for the control treatment (32.44 +/- 6.03%). Membrane integrity and kinetic parameters was not different between treatments. The presence of normal sperm was higher in T2 treatment (13.55 +/- 5.82%) when compared to the control (10.72 +/- 3.53%) and T1 (3.97 +/-& nbsp;1.95%). There was a lower rate of morphological tail damage in the T1 (26.91 +/- 7.13%) treatment compared to the T2 (37.48 +/- 10.81%) and control (45.88 & PLUSMN; 4.84%). For the head morphologies, the lowest percentages were for the control (35.72 +/- 5.89%) and T2 (4.89 +/- 14.94%) treatments compared to the T1 treatment (62.59 +/- 9.67%). In the MTT (3-(4, 5-dimethylthiazolyl-2)2, 5-diphenyltetrazolium bromide) test (AU/100 million sptz), the centrifuged treatments resulted in values of 1.58 +/- 0.79 (T1) and 2.02 +/- 1.88 (T2), better than the treatment control (0.20 +/- 0.08). Likewise, the fertilization and hatching rates, respectly, were better for the T1 (76.68 +/- 15.22% and 54.62 +/- 17.39%) and T2 (69.85 +/- 17.85% and 50.87 +/- 20.59%) treatments, than the control treatment (40.03 +/- 11.67% and 24.14 +/- 13.97%). The comparison of differential centrifugation with density gradient centrifugation was carried out for the first time with cryopreserved milt of R. quelen. In summary, both centrifugation techniques proved to be efficient in obtaining a better portion of functional sperm from thawed milt. This is based on the high rates of embryonic survival and hatching obtained after both differential and density gradient separation
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