25 research outputs found

    Mild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis

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    Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis

    Racism as a determinant of health: a systematic review and meta-analysis

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    Despite a growing body of epidemiological evidence in recent years documenting the health impacts of racism, the cumulative evidence base has yet to be synthesized in a comprehensive meta-analysis focused specifically on racism as a determinant of health. This meta-analysis reviewed the literature focusing on the relationship between reported racism and mental and physical health outcomes. Data from 293 studies reported in 333 articles published between 1983 and 2013, and conducted predominately in the U.S., were analysed using random effects models and mean weighted effect sizes. Racism was associated with poorer mental health (negative mental health: r = -.23, 95% CI [-.24,-.21], k = 227; positive mental health: r = -.13, 95% CI [-.16,-.10], k = 113), including depression, anxiety, psychological stress and various other outcomes. Racism was also associated with poorer general health (r = -.13 (95% CI [-.18,-.09], k = 30), and poorer physical health (r = -.09, 95% CI [-.12,-.06], k = 50). Moderation effects were found for some outcomes with regard to study and exposure characteristics. Effect sizes of racism on mental health were stronger in cross-sectional compared with longitudinal data and in non-representative samples compared with representative samples. Age, sex, birthplace and education level did not moderate the effects of racism on health. Ethnicity significantly moderated the effect of racism on negative mental health and physical health: the association between racism and negative mental health was significantly stronger for Asian American and Latino(a) American participants compared with African American participants, and the association between racism and physical health was significantly stronger for Latino(a) American participants compared with African American participants.<br /

    Factorial invariance testing and latent mean differences for the self-description questionnaire II (short version) with indigenous and non-indigenous Australian secondary school students

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    This investigation reports on the cross-cultural equivalence testing of the Self-Description Questionnaire II (short version; SDQII-S) for Indigenous and non-Indigenous Australian secondary student samples. A variety of statistical analysis techniques were employed to assess the psychometric properties of the SDQII-S for both the Indigenous and non-Indigenous students. In addition, an analysis was conducted to determine whether the latent means of the self-concepts differed significantly between Indigenous and non-Indigenous male and female students. The results demonstrated that the SDQII-S held strong psychometric properties across the Indigenous and non-Indigenous Australian students. Furthermore, the analyses indicated that there were significant differences between Indigenous and non-Indigenous students for 7 of the 13 self-concept facets. Although some question could be raised as to the practical nature of these differences, the measurement equivalence of the SDQII-S for Indigenous and non-Indigenous students may allow researchers to more.33 page(s

    The legacy of racism and Indigenous Australian identity within education

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    © 2014 Taylor & Francis. It may be argued that the emerging discourses focusing on the social, emotional, educational, and economic disadvantages identified for Australia’s First Peoples (when compared to their non-Indigenous counterparts) are becoming increasingly dissociated with an understanding of the interplay between historical and current trends in racism. Additionally, and if not somewhat related to this critique, it can be suggested that the very construction of research from a Western perspective of Indigenous identity (as opposed to identities) and ways of being are deeply entwined within the undertones of epistemological racism still prevalent today. It is the purpose of this article to move beyond the overreliance of outside-based understanding Western epistemologies, and to explore not only the complex nature of both racism and identity from Aboriginal and Torres Strait Islander perspectives, but to also explore the role of education and research in perpetuating varying levels of racism and resistance to Indigenous identity(ies) from a contemporary insider-based standpoint. It is hoped this article will shed some light on the pervasive nature of racism directed at Indigenous Australians, and highlight the need for the continual acceptance, respect, and promotion of Indigenous voices and identities within the educational environment and beyond

    Bigger but not always better: Size and democracy in Israeli amalgamated local governments

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    This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Urban Affairs on 17 Jan 2017, available at: http://www.tandfonline.com/10.1080/07352166.2016.1262701.This study discusses the amalgamation of local governments as a method of creating larger and more effective local governments that place fewer burdens on central government budgets. Beyond economies of scale, our findings from a case study of Israel’s 2003 amalgamation plan support the democracy claim. This study reveals that amalgamation reduces local democracy in terms of voter turnout and representation. The likelihood of having a greater level of local democracy increases in smaller local governments, in terms of population. The new efficiency and democracy approach suggests that a new amalgamated local government must be sufficiently small to maximize local democracy. At the same time, new amalgamated local governments need to be sufficiently large to maximize economies of scale. This study uses field research with in-depth interviews to enhance the findings of the empirical analysis

    Differential gene expression induced by exposure of captive mink to fuel oil: A model for the sea otter

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    Free-ranging sea otters are subject to hydrocarbon exposure from a variety of sources, both natural and anthropogenic. Effects of direct exposure to unrefined crude oil, such as that associated with the Exxon Valdez oil spill, are readily apparent. However, the impact of subtle but pathophysiologically relevant concentrations of crude oil on sea otters is difficult to assess. The present study was directed at developing a model for assessing the impact of low concentrations of fuel oil on sea otters. Quantitative PCR was used to identify differential gene expression in American mink that were exposed to low concentrations of bunker C fuel oil. A total of 23 genes, representing 10 different physiological systems, were analyzed for perturbation. Six genes with immunological relevance were differentially expressed in oil-fed mink. Interleukin-18 (IL-18), IL-10, inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), and complement cytolysis inhibitor (CLI) were down-regulated while IL-2 was up-regulated. Expression of two additional genes was affected; heat shock protein 70 (HSP70) was up-regulated and thyroid hormone receptor (THR) was down-regulated. While the significance of each perturbation is not immediately evident, we identified differential expression of genes that would be consistent with the presence of immune system-modifying and endocrine-disrupting compounds in fuel oil. Application of this approach to identify effects of petroleum contamination on sea otters should be possible following expansion of this mink model to identify a greater number of affected genes in peripheral blood leukocytes