9 research outputs found

    5) Adventures in Statistics II: The Science of doping ... or lack thereof; BRCAPRO: Risk model for carrying a deleterious mutation of BRCA1 or BRCA2 based on family history ... a marriage of Bayes and Mendel

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    This lecture was presented on February 22, 2022. The recorded lecture and slides are available to view and download The Adventures in Statistics II series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics.https://openworks.mdanderson.org/biostatistics_adventures/1004/thumbnail.jp

    1) Adventures in Statistics I: From multi-armed bandit strategies to designs for phase 3 adaptive Bayesian platform clinical trials

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    This lecture was presented on September 28, 2021. The recorded lecture and slides are available to view and download The Adventures in Statistics I series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics. References Berry, DA. (1972). A Bernoulli Two-armed Bandit. Ann Math Statist 43 (3) 871 - 897. Thompson, WR. (1933). On the Likelihood That One Unknown Probability Exceeds Another in View of the Evidence of Two Samples. Biometrika, 25(3/4) 285–94. Scott, SL. (2015). Multi-armed bandit experiments in the online service economy. Appl Stoch Models Bus Ind, 31, 37-49. Berry, DA. (1978). Modified two-armed bandit strategies for certain clinical trials. J Am Stat Assoc, 73(362), 339-345. Woodcock, J, LaVange, LM. (2017). Master protocols to study multiple therapies, multiple diseases, or both. N Engl J Med. 377:62-70. Berry, DA, Chen, RW, Zame, A., Heath, DC, & Shepp, LA. (1997). Bandit Problems With Infinitely Many Arms. Ann Stat, 25 (5), 2103-2116.https://openworks.mdanderson.org/biostatistics_adventures/1000/thumbnail.jp

    2) Adventures in Statistics I: How regulators and journals came to accept and perhaps even embrace adaptive Bayesian clinical trials

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    This lecture was presented on October 26, 2021. Recorded lecture and slides are available to view and download The Adventures in Statistics I was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics. References Biostatistics Software by Quantitative Research Computing at MD Anderson (Desktop/Cloud) Berry DA. Emerging innovations in clinical trial design. Clin Pharmacol Ther. 2016;99(1):82-91. Berry DA. The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research. Mol Oncol. 2015;9(5):951-959. Berry DA. Bayesian clinical trials. Nat Rev Drug Discov. 2006;5(1):27-36. Berry SM, Carlin BP, Lee JJ, and Mueller P. Bayesian Adaptive Methods for Clinical Trials. CRC Press: Boca Raton, FL, 2010. Biswas S, Liu DD, Lee JJ, Berry DA. Bayesian clinical trials at the University of Texas MD Anderson Cancer Center. Clin Trials. 2009;6(3):205-16. Tidwell RSS, Peng SA, Chen M, Liu DD, Yuan Y, Lee JJ. Bayesian clinical trials at The University of Texas MD Anderson Cancer Center: An update. Clin Trials. 2019;16(6):645-656.https://openworks.mdanderson.org/biostatistics_adventures/1001/thumbnail.jp

    (7) Adventures in Statistics II: Multiplicities, P-values, and Observational Studies

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    This lecture was presented on April 26, 2022. The recorded lecture and slides will be available to view and download. The Adventures in Statistics II series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics.https://openworks.mdanderson.org/biostatistics_adventures/1006/thumbnail.jp

    3) Adventures in Statistics I: Adaptive Bayesian platform trials and the role of regulators in promoting clinical trials with complex innovative designs

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    This lecture was presented on November 30, 2021. Recorded lecture and slides are available to view and download The Adventures in Statistics I series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics.https://openworks.mdanderson.org/biostatistics_adventures/1002/thumbnail.jp

    (6) Adventures in Statistics II: Attributing reductions in breast cancer mortality to treatment vs screening: A Bayesian CISNET model

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    This lecture was presented on March 22, 2022. The recorded lecture and slides are available to view and download The Adventures in Statistics II series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics.https://openworks.mdanderson.org/biostatistics_adventures/1005/thumbnail.jp

    4) Adventures in Statistics II: Attributing ancestry: The corny but $B story of genetics of maize ... & Bayes; DNA Profiling

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    This lecture was presented on January 25, 2022. The recorded lecture and slides are available to view and download The Adventures in Statistics II series was organized by Dr. J. Jack Lee and Dr. Yu Shen from the Department of Biostatistics. References Berry DA (1991). Probability of Paternity. In The Use of Statistics in Forensic Science 150-156. New York: Ellis Horwood Limited. (Ed: Aitken CGG, Stoney DA.) Berry DA (1983). Statistics of Disputed Paternity Cases. Invited paper: Proceedings of the Social Statistics Section of the American Statistical Association 131-138. Berry DA, Seltzer JD, Xie C, Wright DL, Smith JSC (2002). Assessing probability of ancestry using simple sequence repeat profiles: Applications to maize hybrids and inbreds. Genetics 161:813-824. Berry DA, Seltzer JD, Xie C, Wright DL, Jones ES, Sebastian S, Smith JSC (2003). Assessing probability of ancestry using simple sequence repeat profiles: Applications to maize inbred lines and soybean varieties. Genetics 165:331-342. Berry DA, Wright DL, Xie C, Seltzer JD, Smith JSC (2005). Using molecular sizes of simple sequence repeats versus discrete binned data in assessing probability of ancestry: Application to maize hybrids. Genetics 170:365-374. Smith JSC, Hoeft E, Cole G, Lu H, Jones ES, Wall SJ, Berry DA (2009). Genetic diversity among US sunflower inbreds and hybrids: Assessing probability of ancestry and potential for use in plant variety protection. Crop Science 49:1295-1303 Berry DA (1990). DNA fingerprinting: What does it prove? Chance 3 (3):15-25. Berry DA (1991). Inferences using DNA profiling in forensic identification and paternity cases (with discussion). Statistical Science 6:175-205. Berry DA, Evett IW, Pinchin R (1992). Statistical inferences in crime investigations using deoxyribonucleic acid profiling (Read paper, with discussion). Journal of the Royal Statistical Society, Series C 41:499-531. Berry DA (1992). Statistical Issues in DNA Identification. In DNA on Trial: Genetic Identification and Criminal Justice 91-108. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. (Ed: Billings PR.) Berry DA (1994). DNA, Statistics and the Simpson Case. Chance 7(4):9-12.https://openworks.mdanderson.org/biostatistics_adventures/1003/thumbnail.jp

    Is Axillary Lymph Node Dissection Indicated for Early Stage Breast Cancer--A Decision Analysis

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    NCI P50 CA68438 and the Planning Grant NCI R21-CA68438-01. We are indebted to the Cancer and Leukemia Group B for allowing us to use prognostic data for node-positive breast cancer.
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