10 research outputs found

    Arbovirus emergence in the temperate city of C贸rdoba, Argentina, 2009-2018

    Get PDF
    The distribution of arbovirus disease transmission is expanding from the tropics and subtropics into temperate regions worldwide. The temperate city of C贸rdoba, Argentina has been experiencing the emergence of dengue virus, transmitted by the mosquito Aedes aegypti, since 2009, when autochthonous transmission of the virus was first recorded in the city. The aim of this work is to characterize the emergence of dengue and related arboviruses (Zika and chikungunya) in C贸rdoba since 2009. Herein, we present a data set with all known information about transmission of dengue, Zika, and chikungunya viruses in C贸rdoba, Argentina from 2009-2018, including what information is known of dengue virus (DENV) serotypes in circulation and origins of imported cases. The data presented in this work will assist researchers in investigating drivers of arbovirus emergence and transmission in C贸rdoba, Argentina and contribute to a better understanding of the global problem of the expanding distribution of arbovirus disease transmission.Fil: Robert, Michael A.. University Of The Sciences; Estados UnidosFil: Tinunin, Daniela T.. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Ludue帽a Almeida, Francisco. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Romero, Moory. State University of New York; Estados UnidosFil: Stewart-Ibarra, Anna M.. State University of New York; Estados UnidosFil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentin

    Understanding the role of temporal variation of environmental variables in predicting Aedes aegypti oviposition activity in a temperate region of Argentina

    Get PDF
    Environmental variables related to vegetation and weather are some of the most influential factors that impacting Aedes (Stegomya) aegypti, a mosquito vector of dengue, chikungunya and Zika viruses. In this paper, we aim to develop temporal predictive models for Ae. aegypti oviposition activity utilizing vegetation and meteorological variables as predictors in C贸rdoba city (Argentina). Eggs were collected using ovitraps placed throughout the city from 2009 to 2012 that were replaced weekly. Temporal generalized linear mixed models were developed with negative binomial distributions of errors that model average number of eggs collected weekly as a function of vegetation and meteorological variables with time lags. The best model included a vegetation index, vapor pressure of water, precipitation and photoperiod. With each unit of increment in vegetation index per week the average number of eggs increased by 1.71 in the third week. Furthermore, each millimeter increase of accumulated rain during 4 weeks was associated with a decrease of 0.668 in the average number of eggs found in the following week. This negative effect of precipitation could occur during abundant rainfalls that fill containers completely, thereby depriving females of oviposition sites and leading them to search for other suitable breeding sites. Furthermore, the average number of eggs increased with the photoperiod at low values of mean vapor pressure; however the average number of eggs decreased at high values of mean vapor pressure, and the positive relationship between the response variable and mean vapor pressure was stronger at low values of photoperiod. Additionally, minimum temperature was associated positively with oviposition activity and that low minimum temperatures could be a limiting factor in Ae. aegypti oviposition activity. Our results emphasize the important role that climatic variables such as temperature, precipitation, and vapor pressure play in Ae. aegypti oviposition activity and how these variables along with vegetation indices can be used to inform predictive temporal models of Ae. aegypti population dynamics that can be used for informing mosquito population control and arbovirus mitigation strategies.Fil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Grech, Marta Gladys. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - Patagonia Norte. Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸ica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸nica; ArgentinaFil: Fr铆as C茅spedes, Maria. Provincia de C贸rdoba. Ministerio de Salud; ArgentinaFil: Almiron, Walter Ricardo. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Robert, Michael A.. Virginia Commonwealth University; Estados UnidosFil: Ludue帽a Almeida, Francisco. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentin

    A decade of arbovirus emergence in the temperate southern cone of South America: dengue, Aedes aegypti and climate dynamics in C贸rdoba, Argentina

    Get PDF
    Background: Argentina is located at the southern temperate range of arboviral transmission by the mosquito Aedes aegypti and has experienced a rapid increase in disease transmission in recent years. Here we present findings from an entomological surveillance study that began in C贸rdoba, Argentina, following the emergence of dengue in 2009. Methods: From 2009 to 2017, larval surveys were conducted monthly, from November to May, in 600 randomly selected households distributed across the city. From 2009 to 2013, ovitraps (n = 177) were sampled weekly to monitor the oviposition activity of Ae. aegypti. We explored seasonal and interannual dynamics of entomological variables and dengue transmission. Cross correlation analysis was used to identify significant lag periods. Results: Aedes aegypti were detected over the entire study period, and abundance peaked during the summer months (January to March). We identified a considerable increase in the proportion of homes with juvenile Ae. aegypti over the study period (from 5.7% of homes in 2009鈥10 to 15.4% of homes in 2016鈥17). Aedes aegypti eggs per ovitrap and larval abundance were positively associated with temperature in the same month. Autochthonous dengue transmission peaked in April, following a peak in imported dengue cases in March; autochthonous dengue was not positively associated with vector or climate variables. Conclusions: This longitudinal study provides insights into the complex dynamics of arbovirus transmission and vector populations in a temperate region of arbovirus emergence. Our findings suggest that C贸rdoba is well suited for arbovirus disease transmission, given the stable and abundant vector populations. Further studies are needed to better understand the role of regional human movement.Fil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Sippy, Rachel. University of Florida; Estados Unidos. State University of New York; Estados UnidosFil: Stewart-Ibarra, Anna M.. State University of New York; Estados Unidos. InterAmerican Institute for Global Change Research ; UruguayFil: Grech, Marta Gladys. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - Patagonia Norte. Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸ica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Esquel. Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸nica; ArgentinaFil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Ludue帽a Almeida, Francisco. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Centro de Investigaciones Entomol贸gicas de C贸rdoba; ArgentinaFil: Ainete, Mariela. Provincia de C贸rdoba. Ministerio de Salud; ArgentinaFil: Frias Cespedes, Mar铆a. Provincia de C贸rdoba. Ministerio de Salud; ArgentinaFil: Robert, Michael. University Of The Sciences In Philadelphia. Department Of Mathematics Physics And Statistics.; Estados UnidosFil: Romero, Moory M.. State University of New York; Estados UnidosFil: Almiron, Walter Ricardo. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Centro de Investigaciones Entomol贸gicas de C贸rdoba; Argentin

    Emergencia de Arbovirus en C贸rdoba

    No full text
    Fil: Estallo, Elizabet Lilia. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales; Argentina.Fil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina.Fil: Robert, Michael. Virginia Tech University; Estados Unidos.Fil: Benitez, Elisabet Marina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales; Argentina.Fil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina.Datos correspondientes a extracci贸n de datos de boletines epidemiol贸gicos correspondientes a casos de dengue reportados entre 2009 y 2018, chikungunya 2014-2016 u Zika 2016-2018 en la provincia de C贸rdoba.Fil: Estallo, Elizabet Lilia. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales; Argentina.Fil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina.Fil: Robert, Michael. Virginia Tech University; Estados Unidos.Fil: Benitez, Elisabet Marina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales; Argentina.Fil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina

    MODIS environmental data to assess Chikungunya, Dengue and Zika diseases through Aedes (Stegomia) aegypti oviposition activity estimation

    No full text
    Aedes aegypti is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a main threat for our region. Taking into account this situation, several efforts have been done to use remote sensing to support public health decision making. Moderate resolution imaging spectroradiometer (MODIS) sensor provides moderate-resolution remote sensing products; therefore, we explore the application of MODIS products to vector-borne disease problems in Argentina. We develop temporal forecasting models of Ae. aegypti oviposition, and we include its validation and its application to the 2016 Dengue outbreak. Temporal series (10/2005 to 09/2007) from MODIS products of normalized difference vegetation index and diurnal land surface temperature were built. Two linear regression models were developed: model 1 which uses environmental variables with time lag and model 2 uses environmental variables without time lags. Model 2 was the best model (AIC = 112) with high correlation (r = 0.88, p < 0.05) between observed and predicted data. We can suggest that MODIS products could be a good tool for estimating both Ae. aegypti oviposition activity and risks for Ae. aegypti-borne diseases. That statement is also supported by model results for 2016 when a dengue outbreak that started unusually earlier this season. If such activity could be forecast by a model based on remote sensing data, then a potential outbreak could be predicted.Fil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Centro de Investigaciones Entomol贸gicas de C贸rdoba; ArgentinaFil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Centro de Investigaciones Entomol贸gicas de C贸rdoba; ArgentinaFil: Lanfri, Mario Alberto. Comision Nacional de Actividades Espaciales; ArgentinaFil: Scavuzzo, Carlos Marcelo. Comision Nacional de Actividades Espaciales; ArgentinaFil: Almiron, Walter Ricardo. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentina. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Centro de Investigaciones Entomol贸gicas de C贸rdoba; Argentin

    Could land cover influence Aedes aegypti mosquito populations?

    No full text
    Aedes aegypti is mainly found in urban environments, where human activity guarantees the permanent availability of potential larval habitats. The present study aimed to test for a possible association between Ae. aegypti infestation and land cover classes. From 23 February to 22 May 2015, immature mosquitoes (except eggs) were sampled in artificial containers identified in dwellings in C贸rdoba city, Argentina. The proportion of each land cover class was determined by SPOT-5 (Satellites Pour 1'Observation de la Terre or Earth-observing Satellites) image classification. Generalized linear models were developed to assess a suite of predetermined hypotheses and identified cover class variables associated with Ae. aegypti infestation. Arboreal vegetation was identified as the land cover with the greatest relative importance, negatively associated with Ae. aegypti mosquitoes. More infestation was find in areas with less arboreal vegetation, which corresponds to more urbanized areas.Fil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Ludue帽a Almeida, Francisco. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Fr铆as C茅spedes, Mar铆a. Provincia de C贸rdoba. Ministerio de Salud; ArgentinaFil: Almiron, Walter Ricardo. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; Argentin

    Modelado de la actividad de oviposici贸n de Aedes aegypti en la ciudad de C贸rdoba, Argentina (2009-2012)

    No full text
    Aedes aegypti es una especie de importancia sanitaria, ampliamente distribuida alrededor del mundo y que se ha adaptado a vivir en ambientes urbanos. Las variaciones clim谩ticas y ambientales han afectado su distribuci贸n, llevando a esta especie a ocupar nuevos ambientes. Como se sabe que las variables meteorol贸gicas son factores influyentes en la variaci贸n de la abundancia de Ae. aegypti, se propuso como objetivo evaluar la actividad de oviposici贸n del vector en relaci贸n a variables ambientales y meteorol贸gicas en la ciudad de C贸rdoba (Argentina).Fil: Benitez, Elisabet Marina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Estallo, Elizabet Lilia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Grech, Marta Gladys. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - Patagonia Norte. Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸nica. Universidad Nacional de la Patagonia "San Juan Bosco". Centro de Investigaci贸n Esquel de Monta帽a y Estepa Patag贸nica; ArgentinaFil: Frias Cespedes, M.. Gobierno de la Provincia de C贸rdoba. Ministerio de Salud. Direcci贸n de Epidemiolog铆a; ArgentinaFil: Ainete, M.. Gobierno de la Provincia de C贸rdoba. Ministerio de Salud. Direcci贸n de Epidemiolog铆a; ArgentinaFil: Almiron, Walter Ricardo. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaFil: Ludue帽a Almeida, Francisco. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas. Universidad Nacional de C贸rdoba. Facultad de Ciencias Exactas, F铆sicas y Naturales. Instituto de Investigaciones Biol贸gicas y Tecnol贸gicas; ArgentinaXIX Simposio Internacional sobre Enfermedades DesatendidasCiudad Aut贸noma de Buenos AiresArgentinaFundaci贸n Mundo San

    Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

    No full text
    Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10鈥232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77路1%) patients underwent at least one separation attempt and 3817 (65路0%) patients were successfully weaned from ventilation at day 90. 237 (4路0%) patients were transferred before any separation attempt, 153 (2路6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28路3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0-4), and 1013 (22路4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77路1%) patients with separation attempts, 2927 (64路7%) had a short wean (鈮1 day), 457 (10路1%) had intermediate weaning (2-6 days), 433 (9路6%) required prolonged weaning (鈮7 days), and 706 (15路6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31路8%) of 5479 patients died in the intensive care unit and 2095 (38路3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society

    Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

    No full text
    Background Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings Between Oct 4, 2017, and June 25, 2018, 10鈥232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77路1%) patients underwent at least one separation attempt and 3817 (65路0%) patients were successfully weaned from ventilation at day 90. 237 (4路0%) patients were transferred before any separation attempt, 153 (2路6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28路3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0鈥4), and 1013 (22路4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77路1%) patients with separation attempts, 2927 (64路7%) had a short wean (鈮1 day), 457 (10路1%) had intermediate weaning (2鈥6 days), 433 (9路6%) required prolonged weaning (鈮7 days), and 706 (15路6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31路8%) of 5479 patients died in the intensive care unit and 2095 (38路3%) of 5465 patients died in hospital. Interpretation In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates

    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)