1,382 research outputs found

    Effects of ionizing radiation on charge-coupled imagers

    Get PDF
    The effects of ionizing radiation on three different charge coupled imagers have been investigated. Device performance was evaluated as a function of total gamma ray dose. The principal failure mechanisms have been identified for each particular device structure. The clock and bias voltages required for high total dose operation of the devices are presented

    Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

    Get PDF
    Systemic inflammation is linked with development and persistence of many pathological pain states. Although chronic phase inflammatory responses are well reported, the acute phase has received limited attention. Here we investigated circulating pro-inflammatory cytokines and C-reactive protein (CRP), and explored their relationships with symptom severity and other factors in acute low back pain (LBP). Ninety-nine individuals within two weeks of onset of acute LBP and 55 pain-free controls completed questionnaires related to their pain (visual analogue scale, VAS) and disability, behaviour, sleep quality and psychological status. CRP, interleukin-6 (IL-6), tumor necrosis factor (TNF) and interleukin-1β (IL-1β) were measured from serum samples. Biomarkers were compared between LBP and control participants, and in a separate analysis, for those with “high-pain” (VAS ⩾4) and “low-pain” (VA

    Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics.

    Get PDF
    The fascial system builds a three-dimensional continuum of soft, collagen-containing, loose and dense fibrous connective tissue that permeates the body and enables all body systems to operate in an integrated manner. Injuries to the fascial system cause a significant loss of performance in recreational exercise as well as high-performance sports, and could have a potential role in the development and perpetuation of musculoskeletal disorders, including lower back pain. Fascial tissues deserve more detailed attention in the field of sports medicine. A better understanding of their adaptation dynamics to mechanical loading as well as to biochemical conditions promises valuable improvements in terms of injury prevention, athletic performance and sports-related rehabilitation. This consensus statement reflects the state of knowledge regarding the role of fascial tissues in the discipline of sports medicine. It aims to (1) provide an overview of the contemporary state of knowledge regarding the fascial system from the microlevel (molecular and cellular responses) to the macrolevel (mechanical properties), (2) summarise the responses of the fascial system to altered loading (physical exercise), to injury and other physiological challenges including ageing, (3) outline the methods available to study the fascial system, and (4) highlight the contemporary view of interventions that target fascial tissue in sport and exercise medicine. Advancing this field will require a coordinated effort of researchers and clinicians combining mechanobiology, exercise physiology and improved assessment technologies

    Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: impact of stimulus type, sleep, psychological and lifestyle factors

    Get PDF
    Generalised hyperalgesia and impaired pain modulation are reported in chronic low back pain (LBP). Few studies have tested whether these features are present in the acute-phase. This study aimed to test for differences in pain presentation in early-acute LBP and evaluate the potential contribution of other factors to variation in sensitivity. Individuals within two weeks of onset of acute LBP (N=126) and pain-free controls (N=74) completed questionnaires related to their pain, disability, behaviour and psychological status before undergoing conditioned pain modulation (CPM) and pain threshold (heat, cold and pressure) testing at the back and forearm/thumb. LBP participants were more sensitive to heat and cold at both sites and pressure at the back than controls, without differences in CPM. Only those with high-pain (numerical rating scale, NRS≥4) were more sensitive to heat at the forearm and pressure at the back. Four subgroups with distinct features were identified: "high sensitivity", "low CPM efficacy", "high sensitivity/low CM efficacy", and "low sensitivity/high CPM efficacy". Various factors such as sleep and alcohol were associated with each pain measure. Results provide evidence for generalised hyperalgesia in many, but not all, individuals during acute LBP, with variation accounted for by several factors. Specific pain phenotypes provide candidate features to test in longitudinal studies of LBP outcome

    An Interlaboratory Study on the Stability of All-Printable Hole Transport Material–Free Perovskite Solar Cells

    Get PDF
    Comparisons between different laboratories on long-term stability analyses of perovskite solar cells (PSCs) is still lacking in the literature. This work presents the results of an interlaboratory study conducted between five laboratories from four countries. Carbon-based PSCs are prepared by screen printing, encapsulated, and sent to different laboratories across Europe to assess their stability by the application of three ISOS aging protocols: (a) in the dark (ISOS-D), (b) under simulated sunlight (ISOS-L), and (c) outdoors (ISOS-O). Over 1000 h stability is reported for devices in the dark, both at room temperature and at 65 degrees C. Under continuous illumination at open circuit, cells survive only for few hours, although they recover after being stored in the dark. Better stability is observed for cells biased at maximum power point under illumination. Finally, devices operate in outdoors for 30 days, with minor degradation, in two different locations (Barcelona, Spain and Paola, Malta). The findings demonstrate that open-circuit conditions are too severe for stability assessment and that the diurnal variation of the photovoltaic parameters reveals performance to be strongly limited by the fill factor, in the central hours of the day, due to the high series resistance of the carbon electrode

    Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

    Get PDF
    This paper presents measurements of the W+μ+νW^+ \rightarrow \mu^+\nu and WμνW^- \rightarrow \mu^-\nu cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

    Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector