3 research outputs found

    Diversity of Eastern Pacific <i>Terebra</i>.

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    <p>The figure shows the diversity of the venomous eastern Pacific forms tentatively assigned to Clade C, <i>Terebra</i>. The samples from Mexico, labeled (b–d), appear different to the samples from Panama, which are labeled (e–f). These are compared to the left-most specimen (a), <i>Terebra subulata</i> from the western Pacific and the right-most specimen (f), <i>Terebra taurina</i> from the western Atlantic.</p

    Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products

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    Serotonin (5-HT) receptors are important in health and disease, but the existence of 14 subtypes necessitates selective ligands. Previously, the pulicatins were identified as ligands that specifically bound to the subtype 5-HT<sub>2B</sub> in the 500 nM to 10 μM range and that exhibited <i>in vitro</i> effects on cultured mouse neurons. Here, we examined the structure–activity relationship of 30 synthetic and natural pulicatin derivatives using binding, receptor functionality, and <i>in vivo</i> assays. The results reveal the 2-arylthiazoline scaffold as a tunable serotonin receptor-targeting pharmacophore. Tests in mice show potential antiseizure and antinociceptive activities at high doses without motor impairment
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