1,044 research outputs found

    A measurement of the \u3ci\u3eWγ\u3c/i\u3e cross section at √S = 8 TEV in \u3ci\u3ePP\u3c/i\u3e collisions with the CMS detector

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    A measurement of cross section of the Wγ → lνγ production in proton-proton collisions using 19.6 fb − 1 of LHC data collected by CMS detector at the center- √ of-mass collision energy of s = 8 TeV is reported. The W bosons are identified in their electron and muon decay modes. The process of Wγ production in the Standard Model (SM) involves a pure gauge boson coupling, a WWγ vertex, which allows one to test the electroweak sector of the SM in a unique way not achievable by studies of other processes. In addition to the total cross section, we measure the differential cross section of Wγ production as a function of a photon transverse momentum. The measurement of the differential cross section is a sensitive probe for new physics originating from an anomalous gauge coupling because possible effects of its presence increase with the photon transverse momentum and, thus, are more likely to be observed in the differential than in the total cross section. The results of this measurement agree with the Standard Model prediction at NLO in QCD, and no evidence of an anomalous triple gauge coupling has been observed. The reported total cross section measurement is the first measurement of this quantity at the 8 TeV collision energy with CMS data. The differential cross section measurement discussed in this dissertation is the first ever measurement of this process performed by CMS since the start of the LHC. Adviser: Ilya Kravchenk

    Management of Energy Saving 0f the Industrial Enterprise: Essence and Organizational and Economic Tools

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    Innovative and effective energy sector creation is a key point for international companies in time of resource globalization. Energy efficiency police is anissue of resource-saving . The target of this article is to work out the methods of energy efficiency increase during all energy production and consumption steps (as an example, international company)

    Advantages of Nanosensors in the Development of Interfaces for Bioelectric Prostheses

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    The present research aims to explore the bioelectric activity of muscles using a high-resolution electromyograph and to analyze the prospects of the electromyograph to develop bioelectric patterns for the prosthesis control method based on the data recognition system. The activity of the healthy forearm muscles was investigated during the cyclic activity of fingers in different modes. In addition, the impact of filters on the quality and informativity of myoelectric signals, as well as on the development of bioelectric activity patterns was analyzed. The virtually developed bandpass filters were utilized as experimental filters. The filter impact analysis included the comparison of the signal recorded in the frequency band from 0 to 10000 Hz with the signal filtered in the frequency band from 20 to 500 Hz. The research revealed the advantages of a high-resolution electromyogram for the pattern recognition-based myocontrol

    Advantages of Nanosensors in the Development of Interfaces for Bioelectric Prostheses

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    The present research aims to explore the bioelectric activity of muscles using a high-resolution electromyograph and to analyze the prospects of the electromyograph to develop bioelectric patterns for the prosthesis control method based on the data recognition system. The activity of the healthy forearm muscles was investigated during the cyclic activity of fingers in different modes. In addition, the impact of filters on the quality and informativity of myoelectric signals, as well as on the development of bioelectric activity patterns was analyzed. The virtually developed bandpass filters were utilized as experimental filters. The filter impact analysis included the comparison of the signal recorded in the frequency band from 0 to 10000 Hz with the signal filtered in the frequency band from 20 to 500 Hz. The research revealed the advantages of a high-resolution electromyogram for the pattern recognition-based myocontrol

    Assessment the equivalence of the bioanalogue insulin lizpro biphasic 25 (Geropharm-bio, Russia) and Humalog® Mix 25 (Lilly France, France) using the euglycemic hyperinsulinum clamp method on healthy volonters

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    Background: Modern medicine requires use of effective antidiabetic drugs that can imitate the natural profile of insulin in the body of patients with diabetes mellitus. Examples of such preparations include biphasic insulin lispro, which is a mixture of insulin lispro ultra-short action and insulin lispro protamine suspension with prolonged effect. The clinical trials (CT) program for biosimilar insulins contains pharmacology studies: pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety studies. Aims: To demonstrate Biphasic Insulin Lispro 25, suspension for subcutaneous administration, 100 U/ml (GEROPHARM-Bio, Russia) and Humalog® Mix 25, suspension for subcutaneous administration, 100 U/ml (Lilly France, France) have comparable pharmacokinetic profiles under conditions of hyperinsulinemic euglycemic clamp (HEC) in healthy volunteers. Materials and methods: The study was conducted on 48 healthy men aged between 18 to 50 years. This was a double-blind, randomized, crossover study of comparative pharmacokinetics of drugs. The investigational products (IP) were administered before the clamp in a single dose of 0.4 U/kg subcutaneously in the abdominal wall. Regular blood sampling was performed during the study. The insulin concentrations in the samples were determined using an ELISA method. The results of the determination were used to calculate the PK parameters and construct the concentration-time curves. Adjust glucose infusion rates were based on blood glucose measurements. These data were used to calculate the PD parameters. Results: Our results demonstrated that Biphasic Insulin Lispro 25 and Humalog® Mix 25 have comparable PK and PD profiles under conditions of HEC in healthy volunteers. The confidence intervals for the ratio of the geometric mean for Cins.max and AUCins.0–12 were 87.75–99.90% and 83.76–96.98% respectively, which were well within 80–125% limits for establishing comparability. Conclusions: Biphasic Insulin Lispro 25 and Humalog® Mix 25 are equivalent based on this CT applying the HEC technique in healthy volunteers

    The «cut-off point» of vitamin D: a method of suppressing excessive secretion of PTH

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    BACKGROUND: The subject of discussion is the issue of the separation point, which determines sufficient levels of vitamin D for bone health. When determining the adequate reference range of vitamin D, researchers are mainly guided by the results of research, where the level of 25(OH)D is determined, at which the PTH level decreases and reaches a plateau. AIM: To establish the «cut-off point» of vitamin D by suppressing excessive secretion of PTH. MATERIALS AND METHODS: Observational, single-site, single-stage, selective, uncontrolled study of the search for vitamin D levels by the effect on PTH secretion in residents of Tyumen region was conducted (n = 176). All selected study participants determined the level of 25(OH)D and PTH in serum. The calculation of the «cut-off point» was carried out using the method of searching for changes in the correlation dependence of PTH on the level of vitamin D, followed by verification of the data obtained using ROC analysis. RESULTS: A mathematical analysis of the dependence of 25(OH)D and PTH showed the “cut-off point” of vitamin D, equal to – 23.6 ng/ml. CONCLUSION: The “cut-off point” of 23.6 ng/ml is optimal for suppressing excessive PTH secretion. The data obtained may be an incentive for further working out the “cut-off point” of vitamin D for the Russian population and can be used to clarify the classification of deficiency, insufficiency and optimal levels of vitamin D for the population of the Russian Federation

    Search for charge-asymmetric production of W\u27 bosons in tt + jet events from pp collisions at √s = 7 TeV

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    A search is presented for charge-asymmetric production of a W\u27 boson that has been proposed to accommodate the forward–backward asymmetry observed in the production of top–antitop quark pairs at the Tevatron. The new heavy W\u27 boson would be produced in association with a top quark and would decay into top and down quarks. The data correspond to an integrated luminosity of 5.0 fb−1 in pp collisions at a center-of-mass energy of 7 TeV, recorded by the CMS detector at the LHC. No significant excess above the standard model expectations is observed, and, from a combination of the electron-plusjets and muon-plus-jets channels, a 95% confidence level lower limit of 840 GeV/c2 is set on the W\u27 boson mass for a W\u27 boson model with values for coupling constants to top and down quarks gL = 0 and gR = 2. In addition, a kinematic reconstruction of the W[1] resonance mass using the inherent charge asymmetry of this model finds no indication of the presence of W\u27 events in the data

    Evaluation of biosimilarity of RinGlar® (GEROPHARM LLC, Russia) and Lantus® (Sanofi-Aventis Deutschland GmbH, Germany) using the euglycemic hyperinsulinemic clamp technique in patients with type 1 diabetes: double-blind randomized clinical trial

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    Background: Prevention of the development of micro-and macrovascular complications in patients with diabetes melli-tus (DM) encouraged the search for insulin analogues that allow imitating, as close as possible, a normal physiological insulin secretion in healthy people. Biosimilars (bioanalogues of reference products) play an important role in the full provision with high-quality insulin medications throughout patients. The program of clinical trials of insulin bioanalogues includes pharmacology studies: pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety research.Aims: To test whether RinGlar® (GEROPHARM LLC, Russia) and Lantus® (Sanofi-Aventis Deutschland GmbH, Germany) have similar PK and PD profiles in a hyperinsulinemic euglycaemic clamp (HEC) setting in patients with type 1 diabetes mellitus. Permission of the Ministry of Health of the Russian Federation No. 150 of 03/03/2016.Materials and methods: The study was conducted in 42 patients with type 1 diabetes aged 18 to 65 years. A doubleblind, randomized, crossover study of comparative PK and PD of drugs was chosen as a study design. The investigational products were injected after achieving a state of euglycemia before the HEC in a single dose of 0.6 U/kg subcutaneously into the subcutaneous fat of the anterior abdominal wall. During the study, regular blood sampling was performed, the amount of insulin glargine in the samples was determined by ELISA. The results are used to calculate the PK parameters and generate the concentration-time curves. The glucose infusion rate was corrected based on the measurement of glycemia. These data are used to calculate the PD parameters.Results: RinGlar® and Lantus® interventions have comparable PK and PD profiles in HEC setting in patients with type 1 diabetes. This is confirmed by the similarity of the main PK/PD parameters, PK/PD curves, and comparable safety. The confidence intervals of the geometric mean ratio were 81.02% - 120.62% for the PK parameter AUCins0-T, and 85.43% - 115.64% for the PD-parameter AUCGIR0_T, which fall within the specified limits of 80% - 125% to establish comparability between drugs.Conclusions: Results of the clinical trial demonstrate the biosimilarity of the products RinGlar® and Lantus®

    Wrongfulness of the act and current issues of legal regulation

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    It is important that in determining the delictual capacity of an individual, his guilt and the nature of mental attitude to the deed, which can be expressed in the form of intent and negligence, should be taken into account. This requires the establishment of three signs, including awareness by a person of unlawfulness of committed actions, anticipation by a person of the onset in socially harmful (socially dangerous) consequences and a person's attitude to the consequences that have occurred. It should be taken into account that during the reform of the criminal law, close attention should be focused on the presence of a person's motivation for unlawful behavior and the factors that determine it. Among such factors it is proposed to include biological features of personality, including sex, age, state of physical and mental health, state of nervous system, reaction to external stimuli, the presence of pathological deviations, character traits, temperament, level of emotional perception, intellectual and mental abilities

    Study of W boson production in PbPb and pp collisions at √sNN = 2.76 TeV

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    A measurement is presented of W-boson production in PbPb collisions carried out at a nucleon–nucleon (NN) centre-of-mass energy √sNN of 2.76 TeV at the LHC using the CMS detector. In data corresponding to an integrated luminosity of 7.3 μb−1, the number of W → μνμ decays is extracted in the region of muon pseudorapidity |ημ| \u3c 2.1 and transverse momentum pμT \u3e 25 GeV/c. Yields of muons found per unit of pseudorapidity correspond to (159 ± 10(stat.) ± 12(syst.)) × 10−8 W+ and (154 ± 10(stat.) ± 12(syst.)) × 10−8 W− bosons per minimum-bias PbPb collision. The dependence of W production on the centrality of PbPb collisions is consistent with a scaling of the yield by the number of incoherent NN collisions. The yield of W bosons is also studied in a sample of pp interactions at √s = 2.76 TeV corresponding to an integrated luminosity of 231 nb−1. The individual W+ and W− yields in PbPb and pp collisions are found to agree, once the neutron and proton content in Pb nuclei is taken into account. Likewise, the difference observed in the dependence of the positive and negative muon production on pseudorapidity is consistent with next-to-leading-order perturbative QCD calculations
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