26 research outputs found

    √Āfrica: Edici√≥n cr√≠tica, lecturas y material

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    Roberto Arlt es considerado uno de los escritores argentinos más importantes de la primera mitad del siglo XX. A pesar de su fama como novelista y autor de aguafuertes, su rica producción de obras dramáticas sigue siendo poco conocida y poco llevada a la escena en los teatros argentinos e internacionales. Con el presente volumen tratamos de paliar ese olvido parcial mediante la edición crítica de una de sus piezas teatrales más importantes

    Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

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    Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ‚ȧ18 years or macroadenomas with onset ‚ȧ30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

    Le conteur

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    Arlt Roberto. Le conteur. In: Horizons Maghr√©bins - Le droit √† la m√©moire, N¬į31-32, 1996. Tanger au miroir d'elle-m√™me. pp. 177-180

    In memoriam Roberto Arlt (1900-1942)

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    Los siete locos ; Los lanzallamas

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    Tabla de contenidos: Los siete locos. Los lanzallamas

    Un ladrón

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    Arlt Roberto. Un ladr√≥n. In: Caravelle, n¬į79, 2002. Paysanneries latino-am√©ricaines : mythes et r√©alit√©s. Hommage √† Romain Gaignard. pp. 249-256

    La isla desierta

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    In memoriam Roberto Arlt (1900-1942)

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    Aguafuertes y notas periodísticas

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