26 research outputs found

    Cellular, cytokine and microbiologic characteristics of bronchoalveolar lavage from children with CSLD and the association (univariate regression analysis) between the BAL markers of inflammation and NTHi-driven IFN-γ production by blood mononuclear cells.

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    <p><sup>#</sup> β and confidence intervals reported as 100x concentration.</p><p>Cellular, cytokine and microbiologic characteristics of bronchoalveolar lavage from children with CSLD and the association (univariate regression analysis) between the BAL markers of inflammation and NTHi-driven IFN-γ production by blood mononuclear cells.</p

    Cellular, cytokine and clinical characteristics of blood from children with CSLD and the association (univariate regression analysis) between the systemic markers of inflammation and NTHi-driven IFN-γ production by blood mononuclear cells.

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    <p><sup>#</sup> β and confidence intervals reported as 100x concentration.</p><p>Cellular, cytokine and clinical characteristics of blood from children with CSLD and the association (univariate regression analysis) between the systemic markers of inflammation and NTHi-driven IFN-γ production by blood mononuclear cells.</p

    Shows the univariate regression model of NTHi-driven IFN-γ production by blood mononuclear cells and IL-1β a) and IL-6 b) concentration in the bronchoalveolar lavage fluid.

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    <p>As the multivariate analyses showed that only IL-1γ and IL-6 were independently associated with the capacity for NTHi-driven IFN-γ production, other BAL mediators are not shown in the figure.</p

    Demographic characteristics and respiratory history of the cohort.

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    <p><sup>§</sup> scored according to a modified Bhalla scale as previously reported [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129517#pone.0129517.ref013" target="_blank">13</a>].</p><p>Demographic characteristics and respiratory history of the cohort.</p

    Innate (24 hour) cytokine production.

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    <p>In vitro cytokine production by HC (open circles) and CSLD (filled circles) PBMC following 24 hour challenge with NTHi. Delta concentration (NTHi challenge minus nil challenge) with median and IQR.</p

    Adaptive (72 hour) cytokine production to PHA.

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    <p>In vitro cytokine production by HC (open symbols) and CSLD (filled symbols) PBMC following 72 hour challenge with the non-specific mitogen PHA. Delta concentration (NTHi challenge minus nil challenge) with median and IQR.</p

    Serum IgG1 and IgG4 to outer membrane proteins P4 and P6.

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    <p>HC (open circles) and CSLD (filled circles). Concentration with median and inter-quartile range.</p

    Adaptive (72 hour) cytokine production to NTHi.

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    <p>a) In vitro cytokine production by HC (open circles) and CSLD (filled circles) PBMC following 72 hour challenge with NTHi. Delta concentration (NTHi challenge minus nil challenge) with median and IQR. b) Trajectory of adaptive (72 hour) IFN-γ production to NTHi with age. In vitro cytokine production by HC (open circles) and CSLD (filled circles) PBMC following 72 hour challenge with NTHi. Median (delta) concentration, pg/ml.</p
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