16 research outputs found

    Raw Data Monkey Fovea Periphery

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    Multiple microscopic images (X620) used to create a 3D model and video of the anatomy of the foveolar cells<br

    Raw Data Human Fovea

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    Multiple microscopic images (X620) used to make a 3D model and video showing the anatomy of the foveolar cells<br

    Raw data monkey fovea center

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    Multiple microscopic images (X620) used to create a 3D model and video of the anatomy of the foveolar cells<br

    Raw Data Human Fovea Collimated Light

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    Results of light transmission measurement of 3 human retinae (foveal area) <br

    Table showing measurement of length of cones

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    Excel Table showing the results of the measurement of the length of central and periferal cones<br

    Measurement length cones central

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    Figure showing the measurement of the length of the central cones<br

    Raw Data Monkey Foveolar Müller Cells

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    Multiple microscopic images (X620) used to create a 3D model and video of the anatomy of the foveolar mueller cells<br

    Examples of representative transmission electron micrographs of (A) a fenestrated glomerular endothelium and of (B) peripheral <i>versus</i> mesangial portions of the glomerular endothelium (both one day after aflibercept injection).

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    <p>(<b>A</b>) Blood lumen on the upper part, urinary space on the lower part of the image. The healthy glomerular filtration barrier consists of three layers <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113701#pone.0113701-Eremina2" target="_blank">[6]</a>: the fenestrated glomerular endothelial cells, the intervening glomerular basement membrane and the podocyte processes and slit diaphragm. GBM =  glomerular basement membrane, CL =  capillary lumen, POD =  podocyte. Arrows mark glomerular endothelial cells fenestrae (note the absence of diaphragm), asterisks mark podocyte foot processes, arrowheads mark podocyte slit diaphragm. (<b>B</b>) At this magnification, podocyte foot processes (asterisks) allow the clear identification of the capillary lumen (CL). In accordance with our definition, the peripheral portion begins where the endothelium and the glomerular endothelial basement membrane (GBM) run approximately parallel (marked by arrows). Arrows mark direction into which peripheral endothelium begins. In between the arrows the mesangium (Mes) and the mesangial portion of the capillary endothelium (MesE) is located. Note that in the mesangial portion there is no GBM adjacent to the fenestrated endothelium so that the described counting method is not applicable and the endothelium does not show the typical single- layered configuration. Magnification ×20000.</p

    Quantification and normalisation of aflibercept/ranibizumab staining.

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    <p>Results of the analysis of aoi of glomeruli from kidneys of monkeys one and seven days after aflibercept (A) or ranibizumab (B) treatment and the corresponding controls, respectively after staining with the anti-Fc-fragment antibody for aflibercept and the anti-Fab fragment antibody for ranibizumab immune reactivity analysis; t-test against the corresponding control was performed: ** for p<0.001,*** for p<0.0001.</p
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