520 research outputs found

    Observation of the decay Λ b 0  → ψ(2S)pπ−

    Get PDF
    The Cabibbo-suppressed decay Λ b 0  → ψ(2S)pπ− is observed for the first time using a data sample collected by the LHCb experiment in proton-proton collisions corresponding to 1.0, 2.0 and 1.9 fb−1 of integrated luminosity at centre-of-mass energies of 7, 8 and 13 TeV, respectively. The ψ(2S) mesons are reconstructed in the μ+μ− final state. The branching fraction with respect to that of the Λ b 0  → ψ(2S)pK− decay mode is measured to beB(Λ0b→ψ(2S)pπ−)B(Λ0b→ψ(2S)pK−)=(11.4±1.3±0.2)%,B(Λb0→ψ(2S)pπ−)B(Λb0→ψ(2S)pK−)=(11.4±1.3±0.2)%,where the first uncertainty is statistical and the second is systematic. The ψ(2S)p and ψ(2S)π−mass spectra are investigated and no evidence for exotic resonances is found

    Molecular beacon-decorated polymethylmethacrylate core-shell fluorescent nanoparticles for the detection of survivin mRNA in human cancer cells.

    Get PDF
    One of the main goals of nanomedicine in cancer is the development of effective drug delivery systems, primarily nanoparticles. Survivin, an overexpressed anti-apoptotic protein in cancer, represents a pharmacological target for therapy and a Molecular Beacon (MB) specific for survivin mRNA is available. In this study, the ability of polymethylmethacrylate nanoparticles (PMMA-NPs) to promote survivin MB uptake in human A549 cells was investigated. Fluorescent and positively charged core PMMA-NPs of nearly 60nm, obtained through an emulsion co-polymerization reaction, and the MB alone were evaluated in solution, for their analytical characterization; then, the MB specificity and functionality were verified after adsorption onto the PMMA-NPs. The carrier ability of PMMA-NPs in A549 was examined by confocal microscopy. With the optimized protocol, a hardly detectable fluorescent signal was obtained after incubation of the cells with the MB alone (fluorescent spots per cell of 1.90±0.40 with a mean area of 1.04±0.20µm2), while bright fluorescent spots inside the cells were evident by using the MB loaded onto the PMMA-NPs. (27.50±2.30 fluorescent spots per cell with a mean area of 2.35±0.16µm2). These results demonstrate the ability of the PMMA-NPs to promote the survivin-MB internalization, suggesting that this complex might represent a promising strategy for intracellular sensing and for the reduction of cancer cell proliferation

    Measurement of the CKM angle γ using B± → DK± with D → K S 0 π+π−, K S 0 K+K− decays

    Get PDF
    A binned Dalitz plot analysis of B± → DK± decays, with D → K S 0 π+π− and D → K S 0 K+K−, is used to perform a measurement of the CP-violating observables x± and y±, which are sensitive to the Cabibbo-Kobayashi-Maskawa angle γ. The analysis is performed without assuming any Ddecay model, through the use of information on the strong-phase variation over the Dalitz plot from the CLEO collaboration. Using a sample of proton-proton collision data collected with the LHCb experiment in 2015 and 2016, and corresponding to an integrated luminosity of 2.0 fb−1, the values of the CP violation parameters are found to be x− = (9.0 ± 1.7 ± 0.7 ± 0.4) × 10−2, y−= (2.1 ± 2.2 ± 0.5 ± 1.1) × 10−2, x+ = (−7.7 ± 1.9 ± 0.7 ± 0.4) × 10−2, and y+ = (−1.0 ± 1.9 ± 0.4 ± 0.9) × 10−2. The first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty (on the strong-phase measurements. These values are used to obtain γ = (87 − 12+ 11 )∘, rB = 0.086 − 0.014 + 0.013 , and δB = (101±11)°, where rB is the ratio between the suppressed and favoured B-decay amplitudes and δB is the corresponding strong-interaction phase difference. This measurement is combined with the result obtained using 2011 and 2012 data collected with the LHCb experiment, to give γ = (80 − 9 + 10 )∘, rB = 0.080 ± 0.011, and δB = (110 ± 10)°

    Opening the black box of energy throughputs in farm systems: A decomposition analysis between the energy returns to external inputs, internal biomass reuses and total inputs consumed (the Vallès County, Catalonia, c.1860 and 1999)

    Get PDF
    We present an energy analysis of past and present farm systems aimed to contribute to their sustainability assessment. Looking at agroecosystems as a set of energy loops between nature and society, and adopting a farm-operator standpoint at landscape level to set the system boundaries, enthalpy values of energy carriers are accounted for net Final Produce going outside as well as for Biomass Reused cycling inside, and External Inputs are accounted using embodied values. Human Labour is accounted for the fraction of the energy intake of labouring people devoted to perform farm work, considering the local or external origin of their food basket. In this approach the proportion of internal Biomass Reused becomes a hallmark of organic farm systems that tend to save External Inputs, whereas industrial farming and livestock breeding in feedlots tend to get rid of reuses replacing them with inputs coming from outside. Hence, decomposing the internal or external energy throughputs may bring to light their contrasting sociometabolic profiles. A Catalan case study in 1860 and 1990 is used as a test bench to show how revealing this decomposing analysis may be to plot the energy profiles of farm systems and their possible improvement pathways

    Study of the Decay phi --> eta pi0 gamma with the KLOE detector

    Full text link
    In a sample of 5.3x10^7 phi-decays observed with the KLOE detector at the Frascati phi-factory Dafne we find 605 eta pi0 gamma events with eta --> gamma\gamma and 197 eta pi0 gamma events with eta --> pi+ pi- pi0. The decay phi --> eta pi0 gamma is dominated by the process phi --> a0 gamma. From a fit to the eta pi0 mass spectrum we find BR(phi --> ao(980) gamma)= (7.4 +- 0.7)x10^-5.Comment: 12 pages, 6 figures, submitted to Phys.Lett.