A Large Web-Based Observer Reliability Study of Early Ischaemic Signs on Computed Tomography. The Acute Cerebral CT Evaluation of Stroke Study (ACCESS)

BACKGROUND: Early signs of ischaemic stroke on computerised tomography (CT) scanning are subtle but CT is the most widely available diagnostic test for stroke. Scoring methods that code for the extent of brain ischaemia may improve stroke diagnosis and quantification of the impact of ischaemia. METHODOLOGY AND PRINCIPAL FINDINGS: We showed CT scans from patients with acute ischaemic stroke (n = 32, with different patient characteristics and ischaemia signs) to doctors in stroke-related specialties world-wide over the web. CT scans were shown twice, randomly and blindly. Observers entered their scan readings, including early ischaemic signs by three scoring methods, into the web database. We compared observers' scorings to a reference standard neuroradiologist using area under receiver operator characteristic curve (AUC) analysis, Cronbach's alpha and logistic regression to determine the effect of scales, patient, scan and observer variables on detection of early ischaemic changes. Amongst 258 readers representing 33 nationalities and six specialties, the AUCs comparing readers with the reference standard detection of ischaemic signs were similar for all scales and both occasions. Being a neuroradiologist, slower scan reading, more pronounced ischaemic signs and later time to CT all improved detection of early ischaemic signs and agreement on the rating scales. Scan quality, stroke severity and number of years of training did not affect agreement. CONCLUSIONS: Large-scale observer reliability studies are possible using web-based tools and inform routine practice. Slower scan reading and use of CT infarct rating scales improve detection of acute ischaemic signs and should be encouraged to improve stroke diagnosis

Cyclotron resonance of extremely conductive 2D holes in high Ge content strained heterostructures

Cyclotron resonance has been observed in steady and pulsed magnetic fields from high conductivity holes in Ge quantum wells. The resonance positions, splittings and linewidths are compared to calculations of the hole Landau levels

The Ursinus Weekly, May 13, 1976

Ursinus names new Alumni Director • Ursinus Chemistry Dept. receives Du Pont grant • New biomedical program combines M.S. degree with advanced placement in medical school • Dr. Parsons authors text • \u2776 Pa. Dutch Summer study • Grad honors, offices named; Asimov to speak • C.C.C. notes • Editorial: It\u27s time for a change • Letters to the editor • Profile: Chuck Reese • St. Andrews scholar named • Movie review • They do it in the Bearpit • Taren presents paper • Spring fest • Golfers hole-out • Baseball Bears put everything together • The Juan Pearl and Lean Tart show • Dr. Creager retiring • Tribute to Dr. Wessel • Pre-Law Society • New phone numbershttps://digitalcommons.ursinus.edu/weekly/1056/thumbnail.jp

The Ursinus Weekly, March 11, 1976

S.F.A.R.C. review • Attention! • Board of Directors meet • Books donated to Graterford • Voters guide to Pa. primary • Scotland calls • Bloodmobile results • Why they leave • International dessert festival tomorrow • Editorial: Further censorship! • Less money for bio-med! • Letters to the editor: Besides lacking quality; A concerned opinion; The Acclaimed Student-Board Committee: Those who are not fortunate souls!; From an outside observer • ProTheatre stages Richard III • Union boosts Bicen blast • Movie review: Taxi driver • Coffeehouse rated • Review of hoopla! • Women\u27s gymnastics • MAC swimming finals! • Fore coachhttps://digitalcommons.ursinus.edu/weekly/1053/thumbnail.jp