54 research outputs found
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study
- Author
- Abecasis G.R.
- Absher D.
- Ahluwalia T.S.
- Ahmad S.
- Albrecht E.
- Alves A.C.
- Andersson E.A.
- arcOGEN Consortium
- Asselbergs F.W.
- Assimes T.L.
- Bakker S.J.
- Baldassarre D.
- Banasik K.
- Barata L.
- Barcella M.
- Barlassina C.
- Barroso I.
- Beckmann J.S.
- Beilby J.
- Bellis C.
- Benaglio P.
- Bennett D.A.
- Bergman R.N.
- Bergmann S.
- Berndt S.I.
- Bis J.C.
- Blangero J.
- Blüher M.
- Boehm B.O.
- Boehnke M.
- Boerwinkle E.
- Bonnefond A.
- Bonnet F.
- Bonnycastle L.L.
- Boomsma D.I.
- Borecki I.B.
- Bornstein S.R.
- Bottinger E.P.
- Bouchard C.
- Boucher G.
- Boyd H.A.
- Bragg-Gresham J.L.
- Broer L.
- Bruinenberg M.
- Buchman A.S.
- Böger C.A.
- Cadby G.
- Campbell H.
- Chakravarti A.
- Chakravarti A.
- Chambers J.C.
- Chanock S.J.
- CHARGE Consortium
- Chasman D.I.
- Chen Y.I.
- Cheng Y.C.
- Chiang C.W.
- Chines P.S.
- Chu S.
- Claudi-Boehm S.
- Clegg D.J.
- Cole J.
- Collins F.S.
- Cucca F.
- Cupples L.A.
- Cusi D.
- Czajkowski J.
- de Bakker P.I.
- de Craen A.J.
- de Faire U.
- de Geus E.J.
- de Groot L.C.
- De Jager P.L.
- Dedoussis G.
- Delgado G.
- Deloukas P.
- Demirkan A.
- den Ruijter H.M.
- DIAGRAM Consortium
- Dimitriou M.
- Duan J.
- Dueker N.
- Ehret G.B.
- Eiriksdottir G.
- Eklund N.
- Enroth S.
- Erdmann J.
- Eriksson J.
- Eriksson J.G.
- Esko T.
- Eury E.
- Evans D.A.
- Fall T.
- Farmaki A.E.
- Farrall M.
- Feenstra B.
- Feitosa M.F.
- Ferreira T.
- Ferrucci L.
- Fischer K.
- Ford I.
- Forouhi N.G.
- Fox C.S.
- Franke L.
- Franks P.W.
- Frau F.
- Friedrich N.
- Froguel P.
- Galesloot T.E.
- Gansevoort R.T.
- Gejman P.V.
- Geller F.
- Gieger C.
- Gigante B.
- GLGC Consortium
- Global-BPGen Consortium
- Glorioso N.
- Go A.S.
- Goel A.
- Gordon-Larsen P.
- Gorski M.
- Gottesman O.
- Graff M.
- Grallert H.
- Grammer T.B.
- Grarup N.
- Groop L.C.
- Gräßler J.
- Grönberg H.
- Gu Y.M.
- Gudnason V.
- Gustafsson S.
- Gyllensten U.
- Haitjema S.
- Hall P.
- Ham A.C.
- Hamsten A.
- Hansen T.
- Harris T.B.
- Hartman C.A.
- Hassinen M.
- Hastie N.
- Hattersley A.T.
- Hayward C.
- Heard-Costa N.L.
- Heath A.C.
- Heid I.M.
- Heliövaara M.
- Henders A.K.
- Hengstenberg C.
- Hernandez D.
- Hicks A.A.
- Hillege H.
- Hingorani A.
- Hirschhorn J.N.
- Hofman A.
- Holmen O.
- Hottenga J.J.
- Hovingh K.G.
- Hu F.
- Huffman J.E.
- Hui J.
- Huikuri H.V.
- Hunter D.J.
- Husemoen L.L.
- Hutri-Kähönen N.
- Hveem K.
- Hysi P.G.
- ICBP Consortium
- Illig T.
- Ingelsson E.
- Jackson A.U.
- Jacobs K.B.
- Jalilzadeh S.
- James A.L.
- Jansen R.
- Jaquish C.E.
- Johansson Å.
- Jordan J.M.
- Jukema J.W.
- Jula A.
- Juonala M.
- Justice A.E.
- Jørgensen T.
- Kaakinen M.
- Kajantie E.
- Kanoni S.
- Kaplan R.C.
- Karaleftheri M.
- Karjalainen J.
- Kathiresan S.
- Khaw K.T.
- Kiemeney L.A.
- Kilpeläinen T.O.
- Kinnunen L.
- Kittner S.J.
- Kivimaki M.
- Kleber M.E.
- Knekt P.B.
- Koenig W.
- Koistinen H.A.
- Kolcic I.
- Kooner J.S.
- Koskinen S.
- Kovacs P.
- Krarup N.T.
- Kratzer W.
- Krüger J.
- Kuh D.
- Kumari M.
- Kutalik Z.
- Kuusisto J.
- Kyriakou T.
- Kähönen M.
- Laakso M.
- Lagou V.
- Lahti J.
- Lakka T.A.
- Langenberg C.
- Lannfelt L.
- Lanzani C.
- Launer L.J.
- Leander K.
- Lehne B.
- Lehtimäki T.
- Lettre G.
- Levinson D.F.
- Lind L.
- Lindgren C.M.
- Lindström J.
- Linneberg A.
- Liu Y.
- Liu Y.P.
- Lo K.S.
- Lobbens S.
- Lokki M.L.
- Loos R.J.
- Lorentzon M.
- Lotay V.
- Lu Y.
- Luan J.
- Luben R.
- Lyssenko V.
- Madden P.A.
- Maerz W.
- MAGIC Consortium
- Magnusson P.K.
- Mahajan A.
- Mangino M.
- Martin N.G.
- Mateo Leach I.
- McArdle W.L.
- McCarthy M.I.
- McKnight B.
- Medina-Gomez C.
- Melbye M.
- Menni C.
- Merger S.
- Metspalu A.
- Mihailov E.
- Milani L.
- Mitchell B.D.
- Mohlke K.L.
- Moll F.L.
- Monda K.L.
- Montasser M.E.
- Montgomery G.W.
- Morris A.P.
- Murray J.C.
- Musk A.W.
- Mägi R.
- Männistö S.
- Mäntyselkä P.
- Müller G.
- Müller-Nurasyid M.
- Narisu N.
- Neinast M.D.
- Nelis M.
- Nieminen M.S.
- Njølstad I.
- Nolte I.M.
- North K.E.
- O'Connell J.R.
- Ohlsson C.
- Oldehinkel A.J.
- Ong K.K.
- Oostra B.A.
- Palmer L.J.
- Palotie A.
- Pankow J.S.
- Panoutsopoulou K.
- Pascoe L.
- Pasterkamp G.
- Paternoster L.
- Pedersen N.L.
- Pedersen O.
- Penninx B.W.
- Perola M.
- Pers T.H.
- Pervjakova N.
- Peters A.
- Pichler I.
- Pilia M.G.
- Polaek O.
- Pouta A.
- Pramstaller P.P.
- Prokopenko I.
- Psaty B.M.
- Pérusse L.
- Qi L.
- Quertermous T.
- Raitakari O.T.
- Rankinen T.
- Rao D.C.
- Rauramaa R.
- Rayner N.W.
- Renström F.
- Rheinberger M.
- Ribel-Madsen R.
- Rice K.M.
- Rice T.K.
- Richards M.
- Ridker P.M.
- Rioux J.D.
- Rivadeneira F.
- Rivolta C.
- Rizzi F.
- Rose L.M.
- Rotter J.I.
- Rudan I.
- Ryan K.A.
- Rüeger S.
- Salo P.
- Salomaa V.
- Saltevo J.
- Sanders A.R.
- Sanna S.
- Sarzynski M.A.
- Sattar N.
- Scharnagl H.
- Schlessinger D.
- Scholtens S.
- Schunkert H.
- Schwarz P.E.
- Scott R.A.
- Scott W.R.
- Sebert S.
- Sengupta S.
- Sennblad B.
- Seufferlein T.
- Shi J.
- Shuldiner A.R.
- Silveira A.
- Simino J.
- Sinisalo J.
- Slagboom P.E.
- Smit J.H.
- Smith A.V.
- Snieder H.
- Southam L.
- Sparsø T.H.
- Spector T.D.
- Staessen J.A.
- Stančáková A.
- Stefania B.
- Stefansson K.
- Steinthorsdottir V.
- Stirrups K.
- Stolk R.P.
- Strachan D.P.
- Strawbridge R.J.
- Stringham H.M.
- Stumvoll M.
- Sung Y.J.
- Swertz M.A.
- Swift A.J.
- Syvänen A.C.
- Sørensen T.I.
- Tachmazidou I.
- Tan S.T.
- Tanaka T.
- Tardif J.C.
- Teslovich T.M.
- Teumer A.
- Thorand B.
- Thorleifsson G.
- Thorsteinsdottir U.
- Tremblay A.
- Tremoli E.
- Trompet S.
- Tsafantakis E.
- Tuomilehto J.
- Tyrer J.P.
- Tönjes A.
- Uitterlinden A.G.
- Uusitupa M.
- van der Harst P.
- van der Laan S.W.
- van der Most P.J.
- van der Velde N.
- van Dijk S.C.
- van Duijn C.M.
- van Schoor N.M.
- van Setten J.
- van Vliet-Ostaptchouk J.V.
- Vandenput L.
- Verbeek A.L.
- Vermeulen S.H.
- Verweij N.
- Viikari J.S.
- Vitart V.
- Vlachopoulou E.
- Vohl M.C.
- Vollenweider P.
- Vonk J.M.
- Völker U.
- Völzke H.
- Waeber G.
- Waite L.L.
- Waldenberger M.
- Walker M.
- Walker R.W.
- Wallaschofski H.
- Wang S.R.
- Wang Z.
- Wareham N.J.
- Watkins H.
- Wennauer R.
- Westra H.J.
- White C.C.
- Widén E.
- Wild S.H.
- Willemsen G.
- Willenborg C.
- Wilsgaard T.
- Wilson J.F.
- Winkler T.W.
- Wong A.
- Wright A.F.
- Yang J.
- Yengo L.
- Yerges-Armstrong L.M.
- Yu L.
- Zeggini E.
- Zhang W.
- Zhao J.H.
- Zillikens M.C.
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Peer reviewe
ABINIT : overview and focus on selected capabilities
- Author
- Allan D.C.
- Amadon B.
- Antonius G.
- Applencourt T.
- Baguet L.
- Bieder J.
- Bottin F.
- Bouchet J.
- Bousquet E.
- Bruneval F.
- Brunin G.
- Caliste D.
- Côté M.
- Denier J.
- Dreyer C.
- Ghosez P.
- Giantomassi M.
- Gillet Y.
- Gingras O.
- Gonze X.
- Hamann D.R.
- Hautier G.
- Jollet F.
- Jomard G.
- Martin A.
- Miranda H.P.C.
- Naccarato F.
- Petretto G.
- Pike N.A.
- Planes V.
- Prokhorenko S.
- Rangel T.
- Ricci F.
- Rignanese G.M.
- Romero Aldo H.
- Royo Miquel
- Stengel Massimiliano
- Torrent Marc
- Van Setten M.J.
- Van Troeye B.
- Verstraete Matthieu J.
- Wiktor J.
- Zwanziger J.W.
- Publication venue
- Publication date
- 02/02/2021
- Field of study
ABINIT is probably the first electronic-structure package to have been released under an open-source license about 20 years ago. It implements density functional theory, density-functional perturbation theory (DFPT), many-body perturbation theory (GW approximation and Bethe-Salpeter equation), and more specific or advanced formalisms, such as dynamical mean-field theory (DMFT) and the "temperature-dependent effective potential" approach for anharmonic effects. Relying on planewaves for the representation of wavefunctions, density, and other space-dependent quantities, with pseudopotentials or projector-augmented waves (PAWs), it is well suited for the study of periodic materials, although nanostructures and molecules can be treated with the supercell technique. The present article starts with a brief description of the project, a summary of the theories upon which abinit relies, and a list of the associated capabilities. It then focuses on selected capabilities that might not be present in the majority of electronic structure packages either among planewave codes or, in general, treatment of strongly correlated materials using DMFT; materials under finite electric fields; properties at nuclei (electric field gradient, Mössbauer shifts, and orbital magnetization); positron annihilation; Raman intensities and electro-optic effect; and DFPT calculations of response to strain perturbation (elastic constants and piezoelectricity), spatial dispersion (flexoelectricity), electronic mobility, temperature dependence of the gap, and spin-magnetic-field perturbation. The abinit DFPT implementation is very general, including systems with van der Waals interaction or with noncollinear magnetism. Community projects are also described: generation of pseudopotential and PAW datasets, high-throughput calculations (databases of phonon band structure, second-harmonic generation, and GW computations of bandgaps), and the library libpaw. abinit has strong links with many other software projects that are briefly mentioned
Saponin production from Quillaja genus species. An insight into its applications and biology
- Author
- Adams M.M.
- Antolak H.
- Arrau S.
- Augustin J.M.
- Bankefors J.
- Benedetti R.S.
- Brunner L.
- Bunthoeun P.
- Charerntantanakul W.
- Cibulski S.P.
- Cibulski S.P.
- Copaja S.V.
- Costa F.
- Costa F.
- Dixit V.
- Faria J.T.
- Fellenberg M.A.
- Fernando Guerra
- Fernández-Tejada A.
- Fidan A.F.
- Fischer M.J.C.
- Fleck J.D.
- Fleck J.D.
- Francis G.
- Francis G.
- Garcia S.
- Geyter E.
- Gilabert-Oriol R.
- González-Cruz D.
- Hassan S.B.
- Hu K.
- Hussain M.
- Jiang X.
- Jiang X.
- Jordan M.
- Kamstrup S.
- Katayama S.
- Kezwon A.
- Kite G.C.
- Kubitzki K.
- Kuwahara Y.
- Letelier L.
- Letelier L.
- Luo H.
- Magedans Y.V.
- Maier C.
- Makkar H.P.S.
- Marciani D.J.
- Matveeva T.V.
- Meesapyodsuk D.
- Mello L.M.
- Paepenmüller T.
- Patra A.K.
- Pelah D.
- Pen B.
- Podolak I.
- Prehn D.
- Ramya R.
- Reichert C. L.
- Reichert C.L.
- Rocha T.D.
- Rodríguez-Díaz M.
- Roner M.R.
- San Martin R.
- San Martın R.
- San Martin R.
- Schlotterbeck T.
- Sebastián Sepúlveda
- Sen S.
- Serrano A.E.
- Shang Y.
- Sparg S.G.
- Szakiel A.
- Tam K.I.
- van Setten D.C.
- Velazco S.J.E.
- Velozo J.
- Vidal C.U.J.
- Vinarova L.
- Vizoso P.
- Wallace F.
- Wallace F.
- Xu X.
- Yendo A.M.
- Zengin A.C.
- Zúñiga G.E.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2021
- Field of study
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
- Author
- Altshuler D.
- Asselbergs F.W.
- Balasubramanyam A.
- Barnard J.
- Bauer F.
- Baumert J.
- Bhangale T.
- Bhatt D.L.
- Bielinski S.J.
- Boehnke M.
- Bohm B.O.
- Bowden D.W.
- Braund P.S.
- Bruinenberg M.
- Burton P.R.
- Cappola T.P.
- Casas J.P.
- Castillo B.A.
- Caulfield M.
- Chandrupatla H.R.
- Clarke R.
- Cooper-DeHoff R.M.
- Crook E.D.
- Curtis S.P.
- Danesh J.
- Davey-Smith G.
- Day I.N.
- de Bakker P.I.W.
- de Boer A.
- de Groot M.C.H.
- Doevendans P.A.
- Dominiczak A.
- Dorn G.W.
- Drenos F.
- Elbers C.C.
- Farrall M.
- Ferguson J.
- FitzGerald G.A.
- Fox C.S.
- Furlong C.E.
- Gaunt T.R.
- Gibson Q.
- Gieger C.
- Gilbert-Diamond D.
- Gilhuijs-Pederson L.A.
- Glessner J.T.
- Goel A.
- Gong Y.
- Grant S.F.A.
- Grobbee D.E.
- Guo Y.R.
- Hakonarson H.
- Hamsten A.
- Hastie C.
- Hegele R.
- Hingorani A.D.
- Hofker M.H.
- Huggins G.S.
- Humphries S.E.
- Illig T.
- Jarvik G.P.
- Johnson J.A.
- Johnson T.
- Kao W.H.L.
- Keating B.J.
- Kim C.E.
- Kivimaki M.
- Kleber M.
- Klungel O.H.
- Knowler W.C.
- Koenig W.
- Kottke-Marchant K.
- Kumari M.
- Langaee T.Y.
- Lanktree M.B.
- Lawlor D.A.
- Li M.Y.
- Li Y.R.
- Lobmeyer M.T.
- Maitland-van der Zee AH
- Marz W.
- McCaffery J.
- McCarthy M.
- Mega J.L.
- Meigs J.B.
- Meijs M.F.L.
- Meisinger C.
- Melander O.
- Mitchell B.D.
- Molony C.M.
- Morrow D.A.
- Munroe P.B.
- Murugesan G.
- Musani S.K.
- Nelson C.P.
- Newhouse S.J.
- O'Connell J.R.
- Onland-Moret N.C.
- Padmanabhan S.
- Palmen J.
- Pankow J.S.
- Patel S.R.
- Pepine C.J.
- Peter I.
- Pettinger M.
- Poulter N.
- Price T.S.
- Rader D.J.
- Rafelt S.
- Rajagopalan R.
- Ranchalis J.
- Rasheed A.
- Reilly M.P.
- Reiner A.
- Rich S.S.
- Rosenthal E.
- Rotter J.I.
- Ruczinski I.
- Sabatine M.S.
- Saleheen D.
- Samani N.J.
- Saxena R.
- Schadt E.E.
- Sever P.
- Shah S.
- Shen H.Q.
- Shields D.C.
- Shuldiner A.R.
- Silbernagel G.
- Silverstein R.
- Siscovick D.S.
- Smith E.N.
- Spijkerman A.W.M.
- Stanton A.
- Steffes M.W.
- Talmud P.J.
- Tare A.
- Thorand B.
- Trip M.
- Van der Harst P.
- van der Schouw Y.T.
- van Iperen E.P.A.
- van Setten J.
- van Vliet-Ostaptchouk J.V.
- van der A.
- Verweij N.
- Voight B.F.
- Watkins H.
- Wijmenga C.
- Wilson J.G.
- Wolffenbuttel B.H.R.
- Young T.
- Zafarmand M.H.
- Zhang L.
- Zmuda J.M.
- Publication venue
- Publication date
- 01/01/2012
- Field of study
To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale meta-analyses by using a custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) with similar to 2000 candidate genes in 39 multiethnic population-based studies, case-control studies, and clinical trials totaling 17,418 cases and 70,298 controls. First, meta-analysis of 25 studies comprising 14,073 cases and 57,489 controls of European descent confirmed eight established T2D loci at genome-wide significance. In silico follow-up analysis of putative association signals found in independent genome-wide association studies (including 8,130 cases and 38,987 controls) performed by the DIAGRAM consortium identified a T2D locus at genome-wide significance (GATAD2A/CILP2/PBX4; p = 5.7 x 10(-9)) and two loci exceeding study-wide significance (SREBF1, and TH/INS; p < 2.4 x 10(-6)). Second, meta-analyses of 1,986 cases and 7,695 controls from eight African-American studies identified study-wide-significant (p = 2.4 x 10(-7)) variants in HMGA2 and replicated variants in TCF7L2 (p = 5.1 x 10(-15)). Third, conditional analysis revealed multiple known and novel independent signals within five T2D-associated genes in samples of European ancestry and within HMGA2 in African-American samples. Fourth, a multiethnic meta-analysis of all 39 studies identified T2D-associated variants in BCL2 (p = 2.1 x 10(-8)). Finally, a composite genetic score of SNPs from new and established T2D signals was significantly associated with increased risk of diabetes in African-American, Hispanic, and Asian populations. In summary, large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to T2D risk and suggests substantial overlap of T2D association signals across multiple ethnic groups
A saturated map of common genetic variants associated with human height
- Author
- 't Hart Leen M
- Abecasis Goncalo
- Adair L.S.
- Adams H.H.H.
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer Singh
- Akiyama Masato
- Al-Mulla F.
- Allison Matthew A.
- Andersen Mette korre
- Ani Alireza
- Appadurai Vivek
- Arbeeva Liubov
- Arias Joshua D.
- Arnett D.K.
- Asselbergs F.W.
- Assimes Themistocles
- Attia J.
- Auton Adam
- Banas B.
- Bandinelli S.
- Bartell Eric
- Bennett D.A.
- Bergler T.
- Berndt Sonja I.
- Bharadwaj D.
- Bhaskar Seema
- Bielak Lawrence F.
- Biino G.
- Bin Wei W.
- Bisgaard H.
- Boehnke Michael
- Boerwinkle E.
- Bollepalli Sailalitha
- Bonnycastle Lori L.
- Boomsma D.I.
- Borja J.B.
- Bork-Jensen Jette
- Bouchard C.
- Bowden D.W.
- Bradfield J.P.
- Bradford Y.
- Brandslund I.
- Braund P.S.
- Brody J.A.
- Brumpton B.
- Burgdorf K.S.
- Buring J.E.
- Böger C.A.
- Bønnelykke K.
- Børglum A.D.
- Cade B.E.
- Cai H.
- Cai Q.
- Campbell Archie
- Catamo E.
- Caulfield M.J.
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- Álvarez Marcus
- Åsvold B.O.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
Genetic studies of body mass index yield new insights for obesity biology
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- Workalemahu Tsegaselassie
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- Zemunik T
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- Zhang Weihua
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- Zhao Jing Hua
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- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
Additional file 28 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Academia Sinica Institute of Biomedical Sciences
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Agency for Science Technology and Research (A*STAR)
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arctic Centre Univ. of Groningen
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Attikon University Hospital
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Beijing Tongren Hospital Capital Medical University
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Blood Institute's and Boston University's Framingham Heart Study
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Charité Universitätsmedizin Berlin
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
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- Erasmus University Medical Center
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- Fuchsberger Christian
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- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
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- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
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- Ltd
- Lu Xiangfeng
- Luan Jian’an
- Lund University
- Lund University Diabetes Centre
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- MAHSC University of Manchester
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
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- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Mashhad University of Medical Sciences
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- Minerva Foundation Institute for Medical Research Helsinki
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- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- MRC Human Genetics Unit
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- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nagoya University Graduate School of Medicine
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nanjing University of Chinese Medicine
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- Noordam Raymond
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- Northwestern University
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- Ohio State University
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- Oklahoma City Veterans Affairs Medical Center
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- Singapore Immunology Network (SIgN) Agency for Science Technology and Research Singapore, Biopolis
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- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
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- Swiss Institute of Bioinformatics
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- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turku University Hospital and University of Turku
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- Universidad Adolfo Ibáñez
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- University of the Witwatersrand Faculty of Health Sciences
- University of Toronto
- University of Turku
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- University of Virginia School of Medicine
- University of Washington School of Medicine
- University of Washington Seattle
- University of Western Australia
- University of Zaragoza
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- Universitätsklinikum Regensburg
- Université de Montréal
- UPMC Hillman Cancer Center
- Uppsala University
- Uppsala University
- VA Boston Healthcare System
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- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 28: Table S18. Sex-participation association of the variants with significant sex-specific lipid results
Additional file 33 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Aberdeen Centre for Health Data Science
- Academia Sinica Institute of Biomedical Sciences
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arctic Centre Univ. of Groningen
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Berlin Institute of Health
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christian-Albrechts-Universitaet zu Kiel
- Christofidou Paraskevi
- Chuang Lee-Ming
- Churchill Hospital
- CIBER en Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN)
- CIBIOR
- Cincinnati Children's Hospital Medical Center
- Ciullo Marina
- Clarendon Laboratory
- Clarke Shoa L.
- Clinical Trial Service Unit and Epidemiological Studies Unit
- College of Life Sciences
- College of Medicine
- Columbia University Mailman School of Public Health
- Concas Maria Pina
- Consejo Nacional de Ciencia y Tecnología
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
- Data Tecnica International
- Data Tecnica International
- David Geffen School of Medicine at UCLA
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Deutsches Herzzentrum München
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- EURAC Research Affiliated Institute of the University of Lübeck
- Evans Michele K.
- Ewha Womans University
- Ewha Womans University School of Medicine
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
- Freie Universität Berlin
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graduate School of Medical Sciences
- Graduate School of Medicine
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
- Harokopio University
- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Helsinki University Central Hospital
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- High Tech Campus 4
- Hilliard Austin T.
- Hindy George
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- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
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- Veturi Yogasudha
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- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
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- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 33: Table S22. Mouse genes with lipid phenotypes (silver set)
Additional file 27 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Academy of Scientific and Innovative Research (AcSIR)
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Agency for Science Technology and Research (A*STAR)
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Alexandria University
- Algebra University College
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Atlanta VA Health Care System
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Barts and The London School of Medicine and Dentistry
- Bayyana Swati
- Bechayda Sonny Augustin
- Beijing Institute for Brain Disorders
- Beijing Tongren Hospital Capital Medical University
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- BHF Glasgow Cardiovascular Research Centre Faculty of Medicine
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C.
- Bispebjerg and Frederiksberg Hospital
- Bjerregaard Anne A.
- Black Corri
- Blood Institute's and Boston University's Framingham Heart Study
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bornholms Hospital
- Boston University School of Public Health
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Broad Institute
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Capital Medical University
- Carolina Population Center
- Case Western Reserve University
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Center for Non-Communicable Diseases
- Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Charité Universitätsmedizin Berlin
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Children's Hospital Oakland Research Institute
- Children's Hospital Philadelphia and University of Pennsylvania School of Medicine
- Chinese Academy of Medical Sciences &
- Chinese National Human Genome Center at Shanghai
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
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- Churchill Hospital
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- Clarendon Laboratory
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- Clinical Trial Service Unit and Epidemiological Studies Unit
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- College of Medicine
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- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- CSIR-Centre for Cellular and Molecular Biology
- CSIR-Institute of Genomics and Integrative Biology
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Dasman Diabetes Institute
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- Data Tecnica International
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- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- deCODE genetics/Amgen Inc.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Department of Clinical Neuroscience
- Department of Epidemiology and Data Science Amsterdam UMC
- Department of General Practice Amsterdam UMC
- Department of Nephrology Instituto de Investigaciones Biomédicas Sant Pau
- Dipartimento di Chimica e Farmacia Università di Sassari
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Dromokaiteio Psychiatric Hospital
- Duke-NUS Medical School Singapore
- DZHK (German Centre for Cardiovascular Research) Partner site Greifswald
- Ealing Hospital
- Elders Petra J. M.
- Emory University
- Emory University School of Medicine
- Engmann Jorgen
- Erasmus University Medical Center
- Erdmann Jeanette
- EURAC Research Affiliated Institute of the University of Lübeck
- Evans Michele K.
- Ewha Womans University School of Medicine
- Faculteit Medische Wetenschappen/UMCG
- Faculty of Life Sciences &
- Faisalabad Institute of Cardiology
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Fimlab Laboratories Department of Clinical Chemistry
- Finnish Institute for Health and Welfare
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Fred Hutchinson Cancer Research Center
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- Fuwai Hospital Chinese Academy of Medical Sciences &
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Geisinger
- Genome Institute of Singapore
- George Institute for Global Health at Peking University Health Science Centre
- George Washington University
- German Center for Diabetes Research
- German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
- German Chronic Kidney Disease Study
- German Institute of Human Nutrition
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Glenfield Hospital
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Haessler Jeffrey
- Hakonarson Hakon
- Hallym University
- Han Sohee
- Hansen Torben
- Harbor-UCLA Medical Center
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- Hart Leen M.‘t
- Harvard Medical School
- Harvard School of Public Health
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- High Tech Campus 4
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- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hospital of Southern Jutland
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- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Icahn School of Medicine at Mount Sinai
- Icelandic Heart Association
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Imperial College
- Imperial College and Imperial Healthcare NHS Trust
- Imperial College London
- Ingelsson Erik
- Institute for Biomedicine (affiliated with the University of Lübeck)
- Institute for Maternal and Child Health - IRCCS Burlo Garofolo
- Institute of Astronomy and Astrophysics
- Institute of Epidemiology 2
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Institute of Molecular and Clinical Ophthalmology
- Institute of Nutrition and Functional Foods (INAF)
- Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
- Instituto Nacional de Medicina Genómica
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Interuniversity Cardiology Institute of The Netherlands
- IRCCS Neuromed
- Irvin Marguerite R.
- Istituto di Ricerca Genetica e Biomedica
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Jawaharlal Nehru University
- Ji Yingji
- Jichi Medical University
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- JSS Academy of Higher Education and Research
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- KfH Kidney Center Traunstein
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- King Abdulaziz University
- King's College London
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Klinikum rechts der Isar der TU Muenchen
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kurume University School of Medicine
- Kutalik Zoltan
- Kuusisto Johanna
- Kyoto University Graduate School of Medicine
- Kyung Hee University School of Medicine
- Kyushu University
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Laboratory for Financial Engineering of Laval University
- Lamina Claudia
- Landspitali University Hospital
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Kong Chian School of Medicine
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leiden University Medical Center
- Leipzig University Hospital
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Life Course Epidemiology (LCE)
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jianjun
- Liu Jun
- Lo Ken Sin
- Local Health Unit Toscana Centro
- Locke Adam E.
- Loeffler Markus
- London North West University Healthcare NHS Trust
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Ltd
- Lu Xiangfeng
- Luan Jian’an
- Lund University
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- MAHSC University of Manchester
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Mashhad University of Medical Sciences
- MASPEC Institut
- Massachusetts General Hospital
- Massachusetts General Hospital Cancer Center
- Massachusetts Institute of Technology
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- Mayo Clinic
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medical Faculty Mannheim/Heidelberg University
- Medical University of Graz
- Medina-Gomez Carolina
- Medizinische Universitat Innsbruck
- Meidtner Karina
- Mellström Dan
- Menzies Institute for Medical Research
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Minerva Foundation Institute for Medical Research Helsinki
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- MRC Epidemiology Unit
- MRC Human Genetics Unit
- MRC Unit for Lifelong Health and Ageing
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nagoya University Graduate School of Medicine
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nanjing University of Chinese Medicine
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- National and Capodistrian University of Athens
- National Center for Global Health and Medicine
- National Defense Medical Center Taiwan
- National Institute of Health
- National Institute of Medical Sciences and Nutrition Salvador Zubirán
- National Institute on Aging
- National Institutes of Health Bethesda
- National Taiwan University Hospital
- National University Heart Centre
- National University Heart Centre Singapore
- National Yang Ming Chiao Tung University
- National Yang Ming University
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Newcastle University Business School
- Nielsen Aneta A.
- NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Northwestern University
- Northwestern University Feinberg School of Medicine
- Norwegian University of Science and Technology
- Novo Nordisk Foundation Center for Basic Metabolic Research
- Ntalla Ioanna
- Nutile Teresa
- Obura Morgan O.
- Ohio State University
- Ohlsson Claes
- Okada Yukinori
- Oklahoma City Veterans Affairs Medical Center
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Osaka University Graduate School of Medicine
- Ospedali Riuniti and University of Trieste
- Oulu University
- Oxford University Hospitals Foundation Trust
- O’Donnell Christopher J.
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M.
- Pennell Craig E.
- Pennington Biomedical Research Center
- Penninx Brenda
- Pennsylvania State University
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Privatpraxis Prof Jonas und Dr Panda-Jonas
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- QIMR Berghofer Medical Research Instititute
- Qu Jia
- Quantinuum Research LLC
- Queen Mary University of London
- Queen's University
- Radboud University Nijmegen
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D.C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Regeneron Genetics Center
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- RIKEN Center for Integrative Medical Sciences
- Ripatti Samuli
- Ritchie Marylyn D.
- Rollins School of Public Health
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Rush Alzheimer’s Disease Center
- Rush University Medical Center
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sahlgrenska University Hospital
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Samsung Advanced Institute of Technology
- Sattar Naveed
- Schering-Plough
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- School of Clinical Medicine
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shanghai Institute of Nutrition and Health
- Shimane University School of Medicine
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Singapore Eye Research Institute
- Singapore Immunology Network (SIgN) Agency for Science Technology and Research Singapore, Biopolis
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Southern University of Science and Technology
- Spector Tim D.
- Spracklen Cassandra N.
- St George's University of London
- St. Olavs University Hospital
- Stanford University
- Stanford University School of Medicine
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Sungkyunkwan University
- Sungkyunkwan University School of Medicine
- Surakka Ida
- Swiss Institute of Bioinformatics
- Sygehus Lillebælt
- SYNLAB Medizinisches Versorgungszentrum Weiden GmbH
- Tabara Yasuharu
- Tai EShyong
- Taichung Veterans General Hospital
- Taipei Veterans General Hospital
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tampere University Hospital
- Tampereen Yliopisto
- Tang Hua
- Tardif Jean-Claude
- Technical University of Munich
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- The Institute for Translational Genomics and Population Sciences
- The University of Newcastle
- the University of Texas Health Science
- The University of Texas Health Science Center at Houston
- The University of Tokyo
- The University of Western Australia
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Tohoku University
- Tongji Medical College
- Traunstein Hospital
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turku University Hospital and University of Turku
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universidad Adolfo Ibáñez
- Universidad Nacional Autónoma de México
- University Hospital of Southern Denmark
- University Medical Center Groningen
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- University Medicine Greifswald
- University of Aberdeen
- University of Alabama Birmingham
- University of Bergen
- University of Bristol
- University of California Los Angeles
- University of California San Francisco
- University of Cambridge
- University of College London
- University of Colorado Denver
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- University of Copenhagen Faculty of Health Sciences
- University of Dundee
- University of Eastern Finland
- University of Edinburgh
- University of Essen
- University of Essex
- University of Exeter
- University of Exeter Medical School
- University of Gothenburg
- University of Gothenburg Sahlgrenska Academy
- University of Groningen
- University of Heidelberg
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- University of Lausanne
- University of Leicester
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- University of Michigan Medical School
- University of Michigan School of Public Health
- University of Mississippi Medical Center
- University of Montreal
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- University of Pittsburgh
- University of Pittsburgh Graduate School of Public Health
- University of Queensland
- University of Regensburg
- University of San Carlos
- University of South Carolina
- University of Southern Denmark
- University of Split School of Medicine
- University of Surrey
- University of Sydney
- University of Texas Health Science Center at Houston
- University of the Witwatersrand
- University of the Witwatersrand Faculty of Health Sciences
- University of Toronto
- University of Turku
- University of Utah
- University of Virginia
- University of Washington School of Medicine
- University of Washington Seattle
- University of Zaragoza
- Universität Potsdam
- Universitätsklinikum Regensburg
- Université de Montréal
- Uppsala University
- Uppsala University
- VA Boston Healthcare System
- VA Palo Alto Health Care System
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vanderbilt University Medical Center
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verve Therapeutics
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Virgen de las Nieves University Hospital
- Vitart Veronique
- Vrije Universiteit Amsterdam de Boelelaan
- VU University Medical Center
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Washington University in St. Louis
- Washington University School of Medicine in St. Louis
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weill Cornell Medicine-Qatar
- Weir David R.
- Weiss Stefan
- Wellcome Sanger Institute
- Wellcome Trust Centre for Human Genetics
- Wenzhou Medical University
- Westlake Laboratory of Life Sciences and Biomedicine
- Westlake University
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yong Loo Lin School of Medicine
- Yonsei University
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu Xiang
- Zhu Xiaofeng
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- figshare
- Publication date
- 01/01/2023
- Field of study
Additional file 27: Table S17. Sex-stratified effect sizes in UK Biobank considering all individuals or only those not on cholesterol lowering medications
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