The AISB’08 Symposium on Multimodal Output Generation (MOG 2008)

Welcome to Aberdeen at the Symposium on Multimodal Output Generation (MOG 2008)! In this volume the papers presented at the MOG 2008 international symposium are collected

Drug–drug interactions in pediatric oncology patients

BackgroundDrug–drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic drugs in outpatient pediatric oncology patients.ProcedureAfter informed consent and inclusion, the following information was collected: currently prescribed noncytostatic and cytostatic drugs, comorbidities, and use of over‐the‐counter (OTC) drugs, complementary and alternative medicines (CAMs), and dietary supplements. All medication was screened for DDIs according to two databases: Micromedex® Solutions and the Dutch drug database G‐Standard. The researcher presented DDIs with an associated potential for adverse outcome and a proposal for intervention to three independent experts. If the experts considered a DDI to be potentially clinically relevant and requiring intervention, the physician was notified.ResultsSeventy‐three patients were included (median age 8.9 years). A total of 67 different DDIs were counted (66 in Micromedex® Solutions, 14 in G‐Standard, and 13 DDIs in both databases). The medication reviews resulted in 35 interventions related to 11 different DDIs. The majority of DDIs concerned noncytostatic drugs (25/35) and one third occurred between cytostatic and noncytostatic drugs (10/35). The use of QTc‐interval‐prolonging drugs resulted in one intervention. The use of OTC drugs, CAM, or dietary supplements did not lead to DDIs.ConclusionsThis study resulted in a selection of 11 potentially clinically relevant DDIs for 73 outpatients in our pediatric oncology department. Interventions were formulated in close collaboration between physicians and clinical pharmacists. Future research should focus on assessing DDIs concerning QTc‐interval prolongation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137518/1/pbc26410_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137518/2/pbc26410.pd

Protection, transient stability and fault ride-through issues in distribution networks with dispersed generation

This paper describes the transient stability analysis of a 10 kV distribution network with wind generators, microturbines and CHP plants. The network being modeled in Matlab/Simulink takes into account detailed dynamic models of the generators. Fault simulations at various locations are investigated. For the studied cases, the critical clearing times are calculated. Some network parameters which influence transient stability are also observed. The compliance of DG protection to stability criteria requirements is further studied. The ride-through capability of the DG units is also investigated through transient stability analysis and the equivalent CCT-voltage dip curves are derived. It is concluded that during fault DG unit availability can be increased through modification of undervoltage protection requirements