Boundaries as opportunities: A multilevel investigation of resilience

Within every supply chain (SC), organizations face disruptions that arise because these organizations depend on one another for materials and services. Regrettably, however, the predominant—albeit understandable—focus of extant SC literature on large-scale disruptions has prevented this literature from offering useful insights on how organizations can increase their resilience to the smaller, more typical disruptions that affect organizations nearly daily. Similarly, a principal focus on the organizational and, occasionally, relationship levels of analysis has inhibited extant SC literature from developing a more comprehensive understanding of how multiple organizations may work across or bridge their boundaries to increase their joint resilience. This restricted focus on primarily the organizational level has also limited insights into the role of individuals and teams in ensuring organizational resilience.This dissertation responds to these ambiguities by examining different bridging actions in response to various types of (day-to-day) disruptions and across multiple levels of analysis. We find that a day-to-day disruption is more harmful when it coincides with other such disruptions in the SC, and when it represents an unfamiliar event of which the affected organizations have little relevant experience. We further reveal how bridging actions at the team (information scouting), relationship (promoting breadth and depth), and SC level (cross-boundary information exchange) may assist organizations and SCs in increasing their resilience to, especially, these disruption characteristics. We also demonstrate, however, that such bridging actions become less effective or even counterproductive as situational characteristics become less demanding or when these actions are not attuned to intraorganizational processes

Molecular MRI of Atherosclerotic lesions

This thesis describes the use of MRI contrast agents and vessel wall parameters to image different stages of atherosclerosis. Chapter 2 summerizes different MRI contrast agents targeted towards vulnerable plaques that have been presented in literature. Chapter 3 illustrates accumulation of paramagnetic micelles and liposomes in atherosclerosis, yet have complex kinetics when followed over time. In chapter 4 the use of self-gated MRI was validated to detect contrast agent accumulation in atherosclerotic plaques and assess the vessel wall compliance. The potential of both techniques to monitor plaque progression and anti-atherosclerotic therapy was assessed. In chapter 5 we developed a scavenger receptor-A1 targeted USPIO to detect vulnerable lesions. Chapter 6 describes the application of VCAM-1 targeted USPIO. Imaging at different time points, allows to discriminate early plaques from advanced lesions and can be used to monitor treatment response in ApoE-/- mice. In Chapter 7 an E-selectin targeted USPIO was validated. This USPIO allowed discrimination of lesions rich in macrophages from early lesions. In Chapter 8 we developed a micelle encapsulating rosiglitazone. Targeted delivery to the plaque lead to an anti-atheroscle rotic response without cardiac side-effects. Finally in Chapter 9 the potentials and pitfalls of histological validation of MRI contrast agents are illustrated.NHS (Nederlandse Hartstichting), Guerbet Nederlan

Resilience in interorganizational networks:Dealing with day-to-day disruptions in critical infrastructures

Purpose: Critical infrastructures (CIs) for essential services such as water supply and electricity delivery are notoriously vulnerable to disruptions. While extant literature offers important insights into the resilience of CIs following large-scale disasters, our understanding of CI resilience to the more typical disruptions that affect CIs on a day-to-day basis remains limited. The present study investigates how the interorganizational (supply) network that uses and manages the CI can mitigate the adverse consequences of day-to-day disruptions. Design/methodology/approach: Longitudinal archival data on 277 day-to-day disruptions within the Dutch national railway CI were collected and analyzed using generalized estimating equations. Findings: The empirical results largely support the study’s predictions that day-to-day disruptions have greater adverse effects if they co-occur or are relatively unprecedented. The findings further show that the involved interorganizational network can enhance CI resilience to these disruptions, in particular, by increasing the overall level of cross-boundary information exchange between organizations inside the network. Practical implications: This study helps managers to make well-informed choices regarding the target and intensity of their cross-boundary information-exchange efforts when dealing with day-to-day disruptions affecting their CI. The findings illustrate the importance of targeting cross-boundary information exchange at the complete interorganizational network responsible for the CI and to increase the intensity of such efforts when CI disruptions co-occur and/or are unprecedented. Originality/value: This study contributes to our academic understanding of how network-level processes (i.e. cross-boundary information exchange) can be managed to ensure interorganizational (supply) networks’ resilience to day-to-day disruptions in a CI context. Subsequent research may draw from the conceptual framework advanced in the present study for examining additional supply network-level processes that can influence the effectiveness of entire supply networks. As such, the present research may assist scholars to move beyond a simple dyadic context and toward examining complete supply networks

Infection of Maize by Clavibacter michiganensis subsp. nebraskensis Does Not Require Severe Wounding

Goss’s bacterial wilt and leaf blight of maize is caused by Clavibacter michiganensis subsp. nebraskensis. Infested residue is the primary source of inoculum and infection occurs via wounds caused by sand blasting, hail, or wind damage. The pathogen survives as an epiphyte on maize leaves and, because the disease has been observed on plants in the field with no obvious wounding, we wondered whether infection by epiphytic C. michiganensis subsp. nebraskensis and disease development could occur in the absence of severe wounding. Consequently, greenhouse experiments were done to evaluate disease development in the absence of wounding in ambient and increased humidity conditions. Maize plants at the V4 to V5 crop development stage were spray inoculated with a suspension of C. michiganensis subsp. nebraskensis (108 cells ml−1). Leaf blight incidence was assessed on whole plants and individual leaves; epiphytic populations of C. michiganensis subsp. nebraskensis were monitored by dilution plating of leaf washes; and epiphytic C. michiganensis subsp. nebraskensis colonization was visualized using scanning electron microscopy (SEM). Goss’s leaf blight symptoms were observed on nonwounded plants in ambient (37.0% plant incidence) and increased humidity conditions (60.0% plant incidence). Populations of epiphytic C. michiganensis subsp. nebraskensis survived and increased on maize leaves, particularly at increased humidity. We observed C. michiganensis subsp. nebraskensis colonizing maize leaves in localized sites that included epidermal junctions, cuticle depressions, in and around stomata, and at the base of trichomes. Single cells and aggregates of C. michiganensis subsp. nebraskensis were observed within substomatal chambers using SEM. These data indicate that severe wounding is not necessary for C. michiganensis subsp. nebraskensis infection of maize, and stomata or trichomes may serve as entry points for the bacterium

Elucidation of density profile of self-assembled sitosterol plus oryzanol tubules with small-angle neutron scattering

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Small-angle neutron scattering (SANS) experiments have been performed on self-assembled tubules of sitosterol and oryzanol in triglyceride oils to investigate details of their structure. Alternative organic phases (deuterated and non-deuterated decane, limonene, castor oil and eugenol) were used to both vary the contrast with respect to the tubules and investigate the influence of solvent chemistry. The tubules were found to be composed of an inner and an outer shell containing the androsterol group of sitosterol or oryzanol and the ferulic acid moieties in the oryzanol molecule, respectively. While the inner shell has previously been detected in SAXS experiments, the outer shell was not discernible due to similar scattering length density with respect to the surrounding solvent for X-rays. By performing contrast variation SANS experiments, both for the solvent and structurant, a far more detailed description of the self-assembled system is obtainable. A model is introduced to fit the SANS data; we find that the dimensions of the inner shell agree quantitatively with the analysis performed in earlier SAXS data (radius of 39.4 ± 5.6 Å for core and inner shell together, wall thickness of 15.1 ± 5.5 Å). However, the newly revealed outer shell was found to be thinner than the inner shell (wall thickness 8.0 ± 6.5 Å). The changes in the scattering patterns may be explained in terms of the contrast between the structurant and the organic phase and does not require any subtle indirect effects caused by the presence of water, other than water promoting the formation of sitosterol monohydrate in emulsions with aqueous phases with high water activity

Quality improvement intervention to stimulate early mobilization of critically ill children

Background: Immobility during hospital stay is associated with muscle weakness, delirium, and delayed neurocognitive recovery. Early mobilization of critically ill adults improves their physical functioning and shortens the duration of mechanical ventilation. However, comparable research in children is lacking. Aims: To determine the effects of the implementation of an early mobilization (EM) program on mobility activities for critically ill children and to explore barriers and facilitators and clinical outcomes before and after implementation. Study design: A prospective single-centre before-and-after study. Methods: This study was conducted in a PICU of a large tertiary hospital. Children aged from 3 months to 18 years, with an expected stay of ≥3 days were eligible to participate. In the “before” phase, participants received usual care; in the “after” phase we implemented a multicomponent, multidisciplinary EM protocol. The primary outcome was a change in the process outcome “mobilization activities”. Secondary outcomes were PICU staff opinions on mobilization (survey), safety, process measures, involvement of parents and physical therapist, and clinical outcomes (sedative use and prevalence of delirium). Results: A total of 113 children were included; 55 before and 58 after, with a median age of 31 months (IQR: 10–103) and 35 months (IQR: 7–152), respectively. The number of mobilization activities (per patient per day) had significantly increased from 5 (IQR: 2–7) to 6 (IQR: 4–8) (U = 272185.0; p &lt;.001). PT consultations for mobilization had significantly increased from 23.6% (13/55) to 46.5% (27/58) (X2 = 6.48; p =.011). In both phases, no mobilization-related adverse events were documented. The survey showed that PICU staff found EM of critically ill children useful and feasible. In the after phase, PICU staff rated the perceived benefit of the support of the physical therapist during mobilization activities significantly higher than in the before phase (X2 = 34.80; p &lt;.001). Conclusions: Implementation of a structured EM program for critically ill children is feasible and safe. Relevance to clinical practice: It is suggested to start the implementation of a structed EM program with the idendentification of local barriers and facilitators by an interdisciplinary PICU team. Further, an increased presence of physiotherapists on the PICU would improve mobilisation levels, and facilitate mobilisation in critically ill children. Also, they can support and advice PICU nurses and parents in mobilising children.</p

Fat crystallite thickness distribution based on SAXD peak shape analysis

Understanding of the multiscale structuring capability of triacylglycerols (TAGs) can be enhanced through knowledge of the crystallite thickness distribution (CTD), which can be obtained through X‐ray diffraction peak shape analysis. The Fourier‐transformation‐based Bertaut–Warren–Averbach (BWA) method provides an approach to resolve CTDs in TAGs, where molecules are packed in repeating layers. The feasibility of using the BWA method is demonstrated for small angle X‐ray diffraction (SAXD) measurements on both laboratory equipment and a synchrotron beamline for model TAG systems and real food products such as margarines. Practical Applications: The CTDs enable discrimination of margarines produced by different processing routes and may be used as a signature of network structures that underlie product texture