Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Efecto radiosensibilizante de Ftorafur en el carcinoma avanzado de cabeza y cuello: estudio experimental y clínico

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 14 de Diciembre de 199

Quality of life in patients with breakthrough cancer pain in radiation oncology departments in Spain: the CAVIDIOR study.

Aim: The CAVIDIOR study evaluated quality of life (QoL) in patients with breakthrough cancer pain receiving palliative radiation therapy in radiation oncology departments (RODs) in Spain. Patients & methods: Prospective observational study at 11 Spanish RODs (July 2016-November 2017). QoL was assessed using Short Form Health Survey 12. Secondary end points were sleep quality, caregiver burden and patient/perception of improvement. Results: QoL improved according to the Short Form Health Survey 12 mental component. Sleep quality and caregivers' burden improved significantly. Conclusion: Breakthrough cancer pain is highly prevalent and can be substantially reduced with appropriate diagnosis and management in RODs. Along with the QoL questionnaire, sleep quality and caregiver burden provide a more comprehensive assessment of overall health status in patients receiving radiation therapy in RODs. Clinical trial registration: NCT02836379 (ClinicalTrials.gov)

Embedded Fiber Bragg Grating Sensors for Monitoring Temperature and Thermo-Elastic Deformations in a Carbon Fiber Optical Bench

A composite optical bench made up of Carbon Fiber Reinforced Polymer (CFRP) skin and aluminum honeycomb has been developed for the Tunable Magnetograph instrument (TuMag) for the SUNRISE III mission within the NASA Long Duration Balloon Program. This optical bench has been designed to meet lightweight and low sensitivity to thermal gradient requirements, resulting in a low Coefficient of Thermal Expansion (CTE). In addition to the flight model, a breadboard model identical to the flight one has been manufactured, including embedded fiber Bragg temperature and strain sensors. The aim of this is to explore if the use of distributed fiber Bragg gratings (FBGs) can provide valuable information for strain and temperature mapping of an optical instrument on board a space mission during its operation as well as its on-ground testing. Furthermore, surface-mounted strain FBG sensors and thermocouples have been installed in the optical bench for intercomparison purposes. This paper presents the results obtained from a thermal vacuum test consisting of three thermal cycles with stabilization steps at 100 °C, 60 °C, 20 °C and −20 °C. Experimental results provide information about how FBG embedded temperature sensors can provide a proper and quick response to the temperature changes of the optical bench and that embedded FBG strain sensors are able to measure micro-deformation induced in a close-to-zero CTE optical bench.AEI/MCIN/10.13039/501100011033Depto. de ÓpticaFac. de Óptica y OptometríaTRUEpu

Educación en valores y convivencia escolar

Este proyecto de innovación educativa se presentó en el Congreso Internacional de Innovación en la Educación celebrado en Valladolid los dias 26, 27 y 28 de abril de 2005Proyecto desarrollado en un centro que afronta la dispersión de sus aulas con un proyecto que favorece la convivencia escolar y la educación en valores. El proyecto ha sido realizado por trece profesores. Los alumnos participantes son los pertenecientes al Colegio Rural Agrupado 'Valle del Duerna', formado por nueve aulas, distribuidas en ocho localidades diferentes. El alumnado participante corresponde a los niveles de educación infantil y primaria, las aulas son unitarias. Se han trabajado las siguientes areas curriculares: Lengua, Matemáticas, Conocimiento del Medio, Inglés, Artística y E. Física. Los temas desarrollados durante el curso 'Educación en valores y convivencia escolar', se han centrado en trabajar todas las actividades, a partir de los valores de solidaridad, respeto y tolerancia, englobados dentro de los temas transversales del currículo. Y todo ello, en base a la socialización de los alumnos, que a pesar de pertenecer a un mismo colegio, tienen sus aulas distantes entre cinco y quince kilómetros. Los objetivos planteados son: - Establecer relaciones sociales en ámbitos cada vez más amplios, primero con sus propios compañeros de aula y después con el resto como parte del mismo colegio. - Propiciar situaciones que favorezcan la idea de centro, la solidaridad y tolerancia. - Generalizar el uso de las Tecnologías de la Información como herramienta que posibilite procesos de comunicación entre las distintas aulas y también de aprendizaje. - Recuperar y mantener situaciones relacionadas con el entorno como 'Magosto' o 'Carnaval'. - Valorar la importancia del medio natural manifestando hacia él actitudes de respeto y cuidado, interviniendo en la medida de sus posibilidades. La metodología ha sido eminentemente activa y participativa. Se han mantenido reuniones para planificar y desarrollar cada una de las actividades, se ha preparado en cada escuela-aula la actividad durante las jornadas previas al desarrollo de las actividades programadas con carácter general, así como las celebraciones de vídeoconferencias y 'chats'. También se desarrollaron actividades de tipo individual con el objetivo de fomentar la comunicación entre todos a través del correo electrónico, el chat, el foro de la página web; utilizando todos estos medios como herramienta de unión y comunicación para todo el colegio, durante todo el curso. Para cada una de las actividades se ha elaborado además de la programación específica de la misma, un material para los alumnos con la finalidad de utilizarlo antes durante y después de la actividad. Algunos de estos materiales han sido fichas de trabajo, concursos de marcapáginas, concursos de postales, cuaderno de trabajo, dibujos entre otros. También se han realizado montajes con programas como Front Page y Power Point para determinadas actividades. Trabajo no publicado.Junta de Castilla y LeónCastilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante, s. n.; 47071 Valladolid; Tel. +34983411881; Fax +34983411939ES

Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment With Acute Reperfusion and Simvastatin).

The STARS trial (Stroke Treatment With Acute Reperfusion and Simvastatin) was conducted to demonstrate the efficacy and safety of simvastatin treatment in acute stroke. STARS07 was a multicentre, phase IV, prospective, randomized, double-blind, placebo-controlled trial. Patients with Acute ischemic stroke recruited within 12 hours from symptom onset were randomized to oral simvastatin 40 mg or placebo, once daily for 90 days. Primary outcome was proportion of independent patients (modified Rankin Scale score of ≤2) at 90 days. Safety end points were hemorrhagic transformation, hemorrhagic events, death, infections, and serious adverse events. From April 2009 to March 2014, 104 patients were included. Fifty-five patients received intravenous tissue-type plasminogen activator. No differences were found between treatment arms regarding the primary outcome (adjusted odds ratio, 0.99 [0.35-2.78]; P=0.98). Concerning safety, no significant differences were found in the rate of hemorrhagic transformation of any type, nor symptomatic hemorrhagic transformation. There were no differences in other predefined safety outcomes. In post hoc analyses, for patients receiving tissue-type plasminogen activator, a favorable effect for simvastatin treatment was noted with higher proportion of patients experiencing major neurological recovery (adjusted odds ratio, 4.14 [1.18-14.4]; P=0.02). Simvastatin plus tissue-type plasminogen activator combination seems safe in acute stroke, with low rates of bleeding complications. Because of the low recruitment, the STARS trial was underpowered to detect differences in simvastatin efficacy. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01073007