Testing the Color Charge and Mass Dependence of Parton Energy Loss with Heavy-to-light Ratios at RHIC and LHC

The ratio of nuclear modification factors of high-pT heavy-flavored mesons to light-flavored hadrons (``heavy-to-light ratio'') in nucleus-nucleus collisions tests the partonic mechanism expected to underlie jet quenching. Heavy-to-light ratios are mainly sensitive to the mass and color-charge dependences of medium-induced parton energy loss. Here, we assess the potential for identifying these two effects in D and B meson production at RHIC and at the LHC. To this end, we supplement the perturbative QCD factorized formalism for leading hadron production with radiative parton energy loss. For D meson spectra at high but experimentally accessible transverse momentum (10 < pT < 20 GeV) in Pb-Pb collisions at the LHC, we find that charm quarks behave essentially like light quarks. However, since light-flavored hadron yields are dominated by gluon parents, the heavy-to-light ratio of D mesons is a sensitive probe of the color charge dependence of parton energy loss. In contrast, due to the larger b quark mass, the medium modification of B mesons in the same kinematical regime provides a sensitive test of the mass dependence of parton energy loss. At RHIC energies, the strategies for identifying and disentangling the color charge and mass dependence of parton energy loss are more involved because of the smaller kinematical range accessible. We argue that at RHIC, the kinematical regime best suited for such an analysis of D mesons is 7 < pT < 12 GeV, whereas the study of lower transverse momenta is further complicated due to the known dominant contribution of additional, particle species dependent, non-perturbative effects.Comment: 21 pages RevTex, 9 Figure

The HIV-1 Protein Vpr Targets the Endoribonuclease Dicer for Proteasomal Degradation to Boost Macrophage Infection

The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4DCAF1 ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands. Corresponding ubiquitination targets have not been identified. UNG2 and SMUG1 are the only known substrates for Vpr-directed depletion through CRL4DCAF1. Here we identify the endoribonuclease Dicer as a target of HIV-1 Vpr-directed proteasomal degradation through CRL4DCAF1. We show that HIV-1 Vpr inhibits short hairpin RNA function as expected upon reduction of Dicer levels. Dicer inhibits HIV-1 replication in T cells. We demonstrate that Dicer also restricts HIV-1 replication in human monocyte-derived macrophages (MDM) and that reducing Dicer expression in MDMs enhances HIV-1 infection in a Vpr-dependent manner. Our results support a model in which Vpr complexes with human Dicer to boost its interaction with the CRL4DCAF1 ubiquitin ligase complex and its subsequent degradation

Carga de trabalho de enfermagem e ocorrência de eventos adversos na terapiaintensiva: revisão sistemática

OBJETIVO Identificar evidências sobre a influência da carga de trabalho de enfermagem na ocorrência de eventos adversos (EA) em pacientes adultos internados em Unidade de Terapia Intensiva (UTI). MÉTODO Revisão sistemática da literatura realizada nas bases de dados MEDLINE, CINAHL, LILACS, SciELO, BDENF e Cochrane deestudosem inglês, português ou espanhol, publicados até 2015. Os EA analisados foram infecção, úlcera por pressão (UPP), quedas e erros associados a medicamentos. RESULTADOS Das 594 pesquisas potenciais identificadas, oito compuseram a amostra final da revisão. O NursingActivities Score -NAS (37,5%) e o TherapeuticInterventionScoring System -TISS (37,5%) foram os instrumentos mais utilizados para avaliação da carga de trabalho de enfermagem. Seis pesquisas (75,0%) identificaram influência da sobrecarga de trabalho na ocorrência de infecção, UPP e uso de medicamentos. Uma investigação identificou que o NAS foi fator de proteção para UPP. CONCLUSÃO A carga de trabalho de enfermagem requerida por pacientes na UTI influenciou a ocorrência de EA, e os enfermeiros devem monitorar diariamente esta variável para garantir o correto dimensionamento da equipe e a segurança da assistência prestada.OBJECTIVE To identifyevidences of the influence of nursing workload on the occurrence of adverse events (AE) in adult patients admitted to the intensive care unit (ICU). METHOD A systematic literature review was conducted in the databases MEDLINE, CINAHL, LILACS, SciELO, BDENF, and Cochrane from studies in English, Portuguese, or Spanish, published by 2015. The analyzed AE were infection, pressure ulcer (PU), patient falls, and medication errors. RESULTS Of 594 potential studies, eight comprised the final sample of the review. TheNursing Activities Score (NAS; 37.5%) and the Therapeutic Intervention Scoring System(TISS; 37.5%) were the instruments most frequently used for assessing nursing workload. Six studies (75.0%) identified the influence of work overload in events of infection, PU, and medicationerrors. An investigation found that the NAS was a protective factor for PU. CONCLUSION The nursing workload required by patients in the ICU influenced the occurrence of AE, and nurses must monitor this variable daily to ensure proper sizing of staff and safety of care.OBJETIVO Identificar evidencias acerca de la influencia de la carga laboral de enfermería en la ocurrencia de eventos adversos (EA) en pacientes adultos ingresados en Unidad de Cuidados Intensivos (UCI). MÉTODO Revisión sistemática de la literatura llevada a cabo en las bases de datos MEDLINE, CINAHL, LILACS, SciELO, BDENF y Cochrane de estudios en inglés, portugués o español, publicados hasta 2015. Los EA analizados fueron infección, úlcera por presión (UPP), caídas y errores asociados con fármacos. RESULTADOS De las 594 investigaciones potenciales identificadas, ocho compusieron la muestra final de la revisión. El NursingActivities Score - NAS (37,5%) y el TherapeuticInterventionScoringSystem - TISS (37,5%) fueron los instrumentos más utilizados para evaluación de la carga laboral de enfermería. Seis investigaciones (75,0%) identificaron influencia de la sobrecarga laboral en la ocurrencia de infección, UPP y uso de fármacos. Una investigación identificó que el NAS fue factor de protección para UPP. CONCLUSIÓN La carga laboral de enfermería requerida por pacientes en la UCI influenció la ocurrencia de EA, y los enfermeros deben monitorear a diario dicha variable a fin de asegurar el correcto dimensionamiento del equipo y la seguridad de la asistencia prestada

Summer School on Quantum Many-Body Physics of Ultra-Cold Atoms and Molecules

The aim of this School was to bring together both leading scientists from all over the world to discuss current frontiers of research in ultra-cold atomic and molecular gases and young PhD students, postdocs, researchers working on ultra-cold gases. The program focused on the analysis of novel quantum phases and quantum phase transitions in mono-atomic gases, mixtures of fermionic and bosonic atoms in traps and optical lattices and its applications to quantum information processing and metrology. In particular, ultra-cold gases have been used to simulate many known condensed matter phenomena such as superfluid-insulator transitions, BEC-BCS crossover, Anderson localization with unprecedented control. In addition, the ultra-cold atomic and molecular gases reveal completely new phenomena which are not possible to realize in standard condensed-matter systems, since interactions, hopping, dimensionality and temperature can be fully controlled in traps and optical lattices. The School program combined lectures that pedagogically summarize the main challenges and recent results on each area with short presentations, especially from students and postdocs. We organized a computer based laboratory to make some practice on the numerical simulations of many-body physics of ultracold-cold gases, giving particular importance in this session to quantum Monte Carlo simulations, which are widely used in the context of ultra-cold atomic physics. Poster sessions have been organized

Notas de Flora Hispánica II.

CARRASCO, M. A. &amp; MARliN-BLANCO, C. J. ¡995. Notas de Flora Hispanica, II. Bot. Co,nplutensi.s 20: 75-79 Aportamos datos corológicos de ¡7 táxones de plantas vasculares recolectadas en la España peninsular. Todas ellas son, salvo indicación contraria, novedades para la provincia deque se trate. Dc entre ellas, algunas como Petrorhogia dubia (Rafin.) G. López &amp; Romo, Oxalis articulota Savign y Eclvpto prostrata (L.) L. se citan por primera vez para áreas más amplias.CARRASCO, M. A. &amp; MARliN-BLANCO, C. J. ¡995. Notas de Flora Hispanica, II. Bot. Co,nplutensi.s 20: 75-79 Aportamos datos corológicos de ¡7 táxones de plantas vasculares recolectadas en la España peninsular. Todas ellas son, salvo indicación contraria, novedades para la provincia deque se trate. Dc entre ellas, algunas como Petrorhogia dubia (Rafin.) G. López &amp; Romo, Oxalis articulota Savign y Eclvpto prostrata (L.) L. se citan por primera vez para áreas más amplias

NaroNet: Discovery of tumor microenvironment elements from highly multiplexed images

Many efforts have been made to discover tumor-specific microenvironment elements (TMEs) from immunostained tissue sections. However, the identification of yet unknown but relevant TMEs from multiplex immunostained tissues remains a challenge, due to the number of markers involved (tens) and the complexity of their spatial interactions. We present NaroNet, which uses machine learning to identify and annotate known as well as novel TMEs from self-supervised embeddings of cells, organized at different levels (local cell phenotypes and cellular neighborhoods). Then it uses the abundance of TMEs to classify patients based on biological or clinical features. We validate NaroNet using synthetic patient cohorts with adjustable incidence of different TMEs and two cancer patient datasets. In both synthetic and real datasets, NaroNet unsupervisedly identifies novel TMEs, relevant for the user-defined classification task. As NaroNet requires only patient-level information, it renders state-of-the-art computational methods accessible to a broad audience, accelerating the discovery of biomarker signatures.Comment: 37 pages, 4 figure

Notas de flora hispánica III.

MARTÍN-BLANCO, C. J. &amp; M. A. CARRASCO. 1999. Notes about spanish flora, III. Bot. (`omplutensis 23: 111-113. We present 9 taxa of vascular plants collected in Spain. Among thetn 7 are te first provincial records and 2 of them are Ibe second provincial records. AH of them are testified hy shects deposited in the herbarium of the Vegetal Biology Department of the Universidad Complutense (l-Ierbarium MACB).MARTIN-BLANCO, C. 3. &amp; M. A. CARRASCO. 1999. Notas de flora hispánica, 111. Bot. Complutensis 23: 111-113. Se presentan 9 táxones de plantas vasculares recolectadas en España, de las que siete son primeras citas, y las otras dos son segundas citas para la provincia de que se trate. Sus testimonios están depositados en el herbario MACE de la Facultad de Ciencias Biológicas de la Universidad Complutense

Chorological data for the central spanish flora

(ARRAS&lt; ca, MA. &amp; MÁRrÍN-BLAN(Y&gt;, (7. 1. 1996. [)alos corolágicas para la fIoia del centro de España Bat (`carnjalaletí»/» 21: 71-74. Sc presentan 1&lt;) táxones de plantas vasculares (7 especies y 3 subespecies), recolectadas en el centro de España ( provincias de Ciudad Real y Toledo). Todas son primeras citas provinciales. siendo (le destacar por su interés corc'lógico: Sagina mar/cima C. Don, por ser la primera ves que se recoge en la Cuenca dcl Cuadiauía y llo/ienacker/a cxscapa (Síeven) Koso-Pol, que representa la localidad más occidental del interior peninsular

Actualización de la colección de tipos del herbario MACB.

CARRASCO, M. A. &amp; MARTIN-BLANCO, C. J. 1998. Actualización de la colección de Tipos del Herbario MACH. Bat. Complutensis, 22: 173-178. Se actoaliza la Colección de Tipos del Herbario MACH, indicando la categoria de cada ejemplar y los herbarios que tienen otros tipos de los mismos táxones. Presentamos 6 Holotypus, 7 lsotypus y 3 Paratypus.CARRASCO, M. A. &amp; MARTÍN-BLANCO, C. 1. 1998. Type collection of MACH Herbarium update. BoL. CompJutensis, 22:173-178. In this paper the Type collection of the MACH Herbarium is updated. We indicate the category (Holotypus, lsotypus or Paratypus) of te specimens as well as te herbariums with other type specimens of the same taxa. The new Typus are: 6 Holotypus, 7 Isotypus and 3 Paratypus