A genomic storm in critically injured humans

Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes

75. Learning on the run - Practical strategies for physician learning

As a part of the Center for Learning in Practice’s (CLIP) mandate, a white paper series on topics of relevance to the educational needs of fellows was developed. The first in this series of white papers, was one entitled: Lifelong Learning White Paper - Supporting Physician Lifelong Learning: Strategies, Tools and Recommendations. This white paper focused on a variety of themes including the concept of ‘learning on the run’, which means that learning takes place wherever you are and occurs on a daily basis over the course of one’s work routine. In other words, learning and the learning context is driven by one’s practice context as well as by one’s own career goals and needs. The center for learning in practice is currently producing a series of thematic monographs/booklets for physicians based on the white papers, the first of which is entitled: Learning on the run- practical strategies for physician learning. The purpose of these monographs are to assist physicians with their learning and practice needs and contain a section on how tools and programs within the Maintenance of Certification (MOC) program can enhance and contribute to physician learning strategies. This poster details the content of a draft monograph on ‘learning on the run’ for physicians to use and comment on. These comments will be used to refine and enhance the monograph in order for CLIP to disseminate it more widely across North America. The monograph can also be accessed under CLIP’s section of The Royal College of Physicians and Surgeons of Canada website - http://rcpsc.medical.org/clip/index.ph

Physical layer security of HAPS-based space-air-ground-integrated network with hybrid FSO/RF communication

In this article, we study the physical layer security performance of a downlink space-air-ground-integrated network (SAGIN), where a satellite communicates with the ground user/destination via a high-altitude-platform-station-based relay in the presence of an eavesdropper. In particular, we propose to use hybrid free-space optical (FSO)/radio frequency (RF) transmission to enhance the security of the considered system. Herein, the FSO and RF links are assumed to experience Gamma-Gamma and Shadowed-Rician distributions, respectively. Specifically, we derive exact and asymptotic expressions of secrecy outage probability for the considered SAGIN by employing intensity modulation/direct detection. We provide the numerical and simulation results to validate our analysis.Ministry of Education (MOE)This work was supported in part by the Singapore Ministry of Education Academic Research Fund Tier 1 grants and in part by the Science and Engineering Research Board (SERB) MATRICS Scheme under Grant MTR/2021/000553, Govt. of India

Mineral Resources of the Raymond Mountain Wilderness Study Area, Lincoln County, Wyoming, U. S.

The 32,936-acre Raymond Mountain (WY-04Q-221) Wilderness Study Area lies in the Wyoming salient of the Idaho-Wyoming-Utah overthrust belt, in Lincoln County, extreme west-central Wyoming. The wilderness study area has no identified (known) mineral or energy resources. The wilderness study area has moderate energy resource potential for oil and gas. Less than 10 percent of the area has been leased for oil and gas exploration. The wilderness study area has low energy resource potential for coal, which may occur as thin layers in the Cokeville Formation. The wilderness study area has low mineral resource potential for phosphate. The Phosphoria Formation is only exposed in a fault block west of the study area and is exposed in the study area between Raymond and Rose Canyons. These otherwise deeply buried, unweathered beds contain low P2O6 values. The wilderness study area also has low mineral resource potential for vanadium in the Phosphoria Formation because of the depth of burial. The wilderness study area has low resource potential for other metals, including uranium, for high-purity limestone or dolostone, and for geothermal energy

United States Geological Survey Bulletin 1757-H

From abstract: This report concerns the resource extraction potential for the Adobe Town Wilderness Study Area. There are no identified resources in the study area

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Not AvailableIndian Institute of Soil and Water Conservation (IISWC) and its Research Centres have developed many model watershed projects successfully in India in the past and implemented many Soil and Water Conservation (SWC) technologies for sustainable watershed management. Though many evaluation studies were conducted on these projects in the past but assessment of the post-adoption status of the SWC technologies over a longer period has not been done yet. It was imperative to appraise the behaviour of the farmers with regard to the continuance or discontinuance of the technologies adopted, diffusion or infusion that took place and technological gaps that occurred in due course of time on post watershed programme. Therefore, it was realized that the post-adoption behaviour of beneficiary farmers who have adopted different soil and water conservation technologies for watershed management projects should be studied in detail. The research study was initiated in 2012 as Core project at Vasad as lead Centre along with IISWC headquarter Dehradun, and Centres Agra, Bellary, Chandigarh, Datia, Kota & Ooty, with the specific objectives of the study to measure the extent of post-adoption behaviour (continue-adoption, discontinuance, technological gap, diffusion and infusion) of farmers towards adopted SWC technologies of watershed management. In the present study various indices regarding continue adoption, dis-adoption (discontinuance), technological gap, diffusion, infusion regarding soil and water conservation technologies for watershed management were developed for measurement of post-adoption behaviour of farmers. It was revealed that little less than three-fourth (73.04 %) of SWC technologies were continued adopted and more than one-fourth (27.01%) were discontinued by farmers. Out of the total continue adopted SWC technologies by farmers, little less than one-fifth (18.96 %) of technologies were continued adopted with technological gap. More than one-fourth (27.82%) of SWC technologies were also diffused to other farmers’ fields in nearby villages and on an average 1.23 number of technologies were also infused into the farmers’ fields from outside by their own efforts in the watersheds developed by the IISWC and its Centres.Not Availabl

Improved magnetic anomalies of the Antarctic lithosphere from satellite and near-surface data

The Antarctic magnetic anomaly map compiled marine and airborne surveys collected south of 60 degrees S through 1999 and used Magsat data to help fill in the regional gaps between the surveys. Orsted and CHAMP satellite magnetic observations with greatly improved measurement accuracies and temporal and spatial coverage of the Antarctic, have now supplanted the Magsat data. We combined the new satellite observations with the near-surface survey data for an improved magnetic anomaly map of the Antarctic lithosphere. Specifically, we separated the crustal from the core and external field components in the satellite data using crustal thickness variations estimated from the terrain and the satellite-derived free-air gravity observations. Regional gaps in the near-surface surveys were then filled with predictions from crustal magnetization models that jointly satisfied the near-surface and satellite crustal anomalies. Comparisons in some of the regional gaps that also considered newly acquired aeromagnetic data demonstrated the enhanced anomaly estimation capabilities of the predictions over those from conventional minimum curvature and spherical harmonic geomagnetic field models. We also noted that the growing number of regional and world magnetic survey compilations involve coverage gaps where these procedures can contribute effective near-surface crustal anomaly estimates

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways

Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for the future of medicine. Patients with injuries severe enough to develop multiple organ dysfunction syndrome have multiple immune derangements, including T cell apoptosis and anergy combined with depressed monocyte antigen presentation. Genome-wide expression analysis of highly enriched circulating leukocyte subpopulations, combined with cell-specific pathway analyses, offers an opportunity to discover leukocyte regulatory networks in critically injured patients. Severe injury induced significant changes in T cell (5,693 genes), monocyte (2,801 genes), and total leukocyte (3,437 genes) transcriptomes, with only 911 of these genes common to all three cell populations (12%). T cell-specific pathway analyses identified increased gene expression of several inhibitory receptors (PD-1, CD152, NRP-1, and Lag3) and concomitant decreases in stimulatory receptors (CD28, CD4, and IL-2Rα). Functional analysis of T cells and monocytes confirmed reduced T cell proliferation and increased cell surface expression of negative signaling receptors paired with decreased monocyte costimulation ligands. Thus, genome-wide expression from highly enriched cell populations combined with knowledge-based pathway analyses leads to the identification of regulatory networks differentially expressed in injured patients. Importantly, application of cell separation, genome-wide expression, and cell-specific pathway analyses can be used to discover pathway alterations in human disease