5 research outputs found

    Apollo Spacecraft Systems Analysis Program. Task E-34E - LM Landing Radar Performance over Rough Terrain

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    Performance prediction for LM landing radar over rough terrai

    Analysis of winglets and sweep on wind turbine blades using a lifting line vortex particle method in complex inflow conditions

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    An in-house aero-elastic vortex code, called MIRAS, is used to investigate the aerodynamic performance of winglets and sweep on horizontal-axis wind turbine (HAWT) blades in simple and complex inflow conditions. Previous studies using vortex codes applied to study winglets and blade sweep on HAWTs have typically not considered complex inflow conditions such as turbulent wind and shear. The reasons may include the absence of modeling capability, the computational cost associated with simulating long turbulent time series, and/or the computational cost associated with resolving the blade tips to a very fine level. A preliminary study is performed here, where the MIRAS code is applied on the NREL 5MW wind turbine with an arbitrary winglet shape and blade sweep. Results indicate that wind turbine blades with sweep or winglets might be better in performance compared to their straight blade counterparts

    PTPN4 germline variants result in aberrant neurodevelopment and growth

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    Protein-tyrosine phosphatases (PTPs) are pleomorphic regulators of eukaryotic cellular responses to extracellular signals that function by modulating the phosphotyrosine of specific proteins. A handful of PTPs have been implicated in germline and somatic human disease. Using exome sequencing, we identified missense and truncating variants in PTPN4 in six unrelated individuals with varying degrees of intellectual disability or developmental delay. The variants occurred de novo in all five subjects in whom segregation analysis was possible. Recurring features include postnatal growth deficiency or excess, seizures, and, less commonly, structural CNS, heart, or skeletal anomalies. PTPN4 is a widely expressed protein tyrosine phosphatase that regulates neuronal cell homeostasis by protecting neurons against apoptosis. We suggest that pathogenic variants in PTPN4 confer risk for growth and cognitive abnormalities in humans.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Unknow
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