Observations of Stratocumulus Clouds and Their Effect on the Eastern Pacific Surface Heat Budget along 20°S

This is the publisher's version, also available electronically from http://journals.ametsoc.org/doi/abs/10.1175/JCLI-D-11-00618.1.Widespread stratocumulus clouds were observed on nine transects from seven research cruises to the southeastern tropical Pacific Ocean along 20°S, 75°–85°W in October–November of 2001–08. The nine transects sample a unique combination of synoptic and interannual variability affecting the clouds; their ensemble diagnoses longitude–vertical sections of the atmosphere, diurnal cycles of cloud properties and drizzle statistics, and the effect of stratocumulus clouds on surface radiation. Mean cloud fraction was 0.88, and 67% of 10-min overhead cloud fraction observations were overcast. Clouds cleared in the afternoon [1500 local time (LT)] to a minimum of fraction of 0.7. Precipitation radar found strong drizzle with reflectivity above 40 dBZ. Cloud-base (CB) heights rise with longitude from 1.0 km at 75°W to 1.2 km at 85°W in the mean, but the slope varies from cruise to cruise. CB–lifting condensation level (LCL) displacement, a measure of decoupling, increases westward. At night CB–LCL is 0–200 m and increases 400 m from dawn to 1600 LT, before collapsing in the evening. Despite zonal gradients in boundary layer and cloud vertical structure, surface radiation and cloud radiative forcing are relatively uniform in longitude. When present, clouds reduce solar radiation by 160 W m−2 and radiate 70 W m−2 more downward longwave radiation than clear skies. Coupled Model Intercomparison Project phase 3 (CMIP3) simulations of the climate of the twentieth century show 40 ± 20 W m−2 too little net cloud radiative cooling at the surface. Simulated clouds have correct radiative forcing when present, but models have ~50% too few clouds

A Microfluidic-Based Tyrosine Kinase and Phosphatase Assay

Background: Inappropriate prescribing is a well-known clinical problem in nursing home residents, but few interventions have focused on reducing inappropriate medication use. Objective: To examine successful discontinuation of inappropriate medication use and to improve prescribing in nursing home residents. Design: Pragmatic cluster randomized controlled trial, with clustering by elder care physicians and their wards. Setting: 59 Dutch nursing home wards for long-term care. Patients: Residents with a life expectancy greater than 4 weeks who consented to treatment with medication. Intervention: Multidisciplinary Multistep Medication Review (3MR) consisting of an assessment of the patient perspective, medical history, critical appraisal of medications, a meeting between the treating elder care physician and the pharmacist, and implementation of medication changes. Measurements: Successful discontinuation of use of at least 1 inappropriate drug (that is, without relapse or severe withdrawal symptoms) and clinical outcomes (neuropsychiatric symptoms, cognitive function, and quality of life) after 4 months of follow-up. Results: Nineteen elder care physicians (33 wards) performed the 3MR, and 16 elder care physicians (26 wards) followed standard procedures. A total of 426 nursing home residents (233 in the intervention group and 193 in the control group) were followed for an average of 144 days (SD, 21). In an analysis of all participants, use of at least 1 inappropriate medication was successfully discontinued for 91 (39.1%) residents in the intervention group versus 57 (29.5%) in the control group (adjusted relative risk, 1.37 [95% CI, 1.02 to 1.75]). Clinical outcomes did not deteriorate between baseline and follow-up. Limitations: The 3MR was done only once. Some withdrawal symptoms or relapses may have been missed. Conclusion: The 3MR is effective in discontinuing inappropriate medication use in frail nursing home residents without a decline in their well-being. Primary Funding Source: Netherlands Organisation for Health Research and Development

Stratocumulus Cloud-Top Height Estimates and Their Climatic Implications

A depth-dependent boundary layer lapse rate was empirically deduced from 156 radiosondes released during six month-long research cruises to the southeast Pacific sampling a variety of stratocumulus conditions. The lapse-rate dependence on boundary layer height is weak, decreasing from a best fit of 7.6 to 7.2 K km⁻¹ as the boundary layer deepens from 800 m to 2 km. Ship-based cloud-base heights up to 800 m correspond well to lifting condensation levels, indicating well-mixed conditions, with cloud bases >800 m often 200–600 m higher than the lifting condensation levels. The lapse rates were combined with Moderate Resolution Imaging Spectrometer 11-μm-derived cloud-top temperatures and satellite microwave-derived sea surface temperatures to estimate stratocumulus cloud-top heights. The October-mean cloud-top height structure of the southeast Pacific was then spatially and diurnally characterized. Coastal shoaling is apparent, but so is a significant along-coast cloud-top height gradient, with a pronounced elevation of the cloud-top heights above the Arica Bight at ~20°S. Diurnal cloud-top height variations (inferred from irregular 4-times-daily sampling) can locally reach 250 m in amplitude, and they can help to visualize offshore propagation of free-tropospheric vertical motions. A shallow boundary layer associated with the Chilean coastal jet expands to its north and west in the afternoon. Cloud-top heights above the Arica Bight region are depressed in the afternoon, which may mean that increased subsidence from sensible heating of the Andes dominates an afternoon increase in convergence/upward motion at the exit of the Chilean coastal jet. In the southeast Atlantic during October, the stratocumulus cloud-top heights are typically lower than those in the southeast Pacific. A coastal jet region can also be identified through its low cloud-top heights. Coastal shoaling of the South Atlantic stratocumulus region is mostly uniform with latitude, in keeping with the more linear Namibian/Angolan coastline. The southeast Atlantic shallow cloudy boundary layer extends farther offshore than in the southeast Pacific, particularly at 15°S

Efficacy of Memantine for Agitation in Alzheimer’s Dementia: A Randomised Double-Blind Placebo Controlled Trial

Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other populations found reduced agitation. We tested the primary hypothesis, memantine is superior to placebo for clinically significant agitation, in patients with moderate-to-severe AD

Boundary Layer Structures Over the Northwest Atlantic Derived From Airborne High Spectral Resolution Lidar and Dropsonde Measurements During the ACTIVATE Campaign

The Planetary Boundary Layer Height (PBLH) is essential for studying the lower atmosphere and its interaction with the surface. Usually, it contains a mixed layer (ML) with vertically well-mixed (i.e., nearly constant) specific humidity and potential temperature. Over the ocean, the PBL is usually coupled (vertically well-mixed) and the ML height (MLH) is usually close to PBLH, hence the MLH estimated from the measurements of aerosol backscatter by a lidar is traditionally compared with PBLH determined from radiosondes/dropsondes. However, when the PBL is decoupled (not vertically well mixed), the MLH differs from the PBLH. Here we used dropsondes' thermodynamic profile to evaluate the airborne High-Spectral-Resolution Lidar—Generation 2 (HSRL-2) estimation of MLH and PBLH in airborne field campaign over the northwestern Atlantic (ACTIVATE) from 2020 to 2022. We show that the HSRL-2 has excellent MLH estimation compared to the dropsondes. We also improved the HSRL-2 estimation of PBLH. Further data analysis indicates that these conclusions remain the same for cases with different cloud fractions, and for decoupled PBLs. These results demonstrate the potential of using HSRL-2 aerosol backscatter data to estimate both marine MLH and PBLH and suggest that lidar-derived MLH should be compared with radiosonde/dropsonde-determined MLH (not PBLH) in general

Spatially-coordinated airborne data and complementary products for aerosol, gas, cloud, and meteorological studies: The NASA ACTIVATE dataset

The NASA Aerosol Cloud meTeorology Interactions oVer the western ATlantic Experiment (ACTIVATE) produced a unique dataset for research into aerosol-cloud-meteorology interactions. An HU-25 Falcon and King Air conducted systematic and spatially coordinated flights over the northwest Atlantic Ocean. This paper describes the ACTIVATE flight strategy, instrument and complementary dataset products, data access and usage details, and data application notes

Ship‐based liquid water path estimates in marine stratocumulus

We examine liquid water paths (LWPs) derived from ship‐based microwave radiometer brightness temperature (Tb) measurements collected within southeastern Pacific stratocumulus at 20°S, 85°W in October 2001. The boundary layer was typically well mixed and overcast. Three gaseous absorption models and two liquid dielectric models are evaluated. Total differences in retrieved LWP attributable to microwave absorption model differences are 10–25 g m−2, increasing with LWP. The most recent models produce the lowest LWPs. Most of the differences in the retrieved LWPs are caused by differences in the gaseous absorption models. Liquid dielectric model differences generate LWP differences of ∼6% of the total LWP. Radiosonde‐calculated Tb using the most recent gaseous absorption model compare best to Tb measurements. The remaining LWP uncertainty due to model uncertainty is estimated at 6 g m−2. The pre‐1995 gaseous and liquid absorption models in combination produce LWPs that exceed the calculated adiabatic values. For the 6‐day best estimate LWP time series, the clouds attained LWPs close to the theoretical adiabatic limit for LWPs up to 150 g m−2, decreasing to ∼85% for LWPs of ∼250 g m−2. Such deductions also depend upon how the cloud boundaries, to which the adiabatic calculation is sensitive, are determined. Light drizzle, as inferred from cloud radar reflectivitiy measurements, is common even at low LWPs, but heavy drizzle (radar reflectivities >0 dBZ, equivalent to a cloud base drizzle rate of ∼2 mm d−1) is much less frequent, occurring <10% of the time even for LWPs of 200 g m−2

Stratocumulus Cloud-Top Height Estimates and Their Climatic Implications

Abstract A depth-dependent boundary layer lapse rate was empirically deduced from 156 radiosondes released during six month-long research cruises to the southeast Pacific sampling a variety of stratocumulus conditions. The lapse-rate dependence on boundary layer height is weak, decreasing from a best fit of 7.6 to 7.2 K km−1 as the boundary layer deepens from 800 m to 2 km. Ship-based cloud-base heights up to 800 m correspond well to lifting condensation levels, indicating well-mixed conditions, with cloud bases >800 m often 200–600 m higher than the lifting condensation levels. The lapse rates were combined with Moderate Resolution Imaging Spectrometer 11-μm-derived cloud-top temperatures and satellite microwave-derived sea surface temperatures to estimate stratocumulus cloud-top heights. The October-mean cloud-top height structure of the southeast Pacific was then spatially and diurnally characterized. Coastal shoaling is apparent, but so is a significant along-coast cloud-top height gradient, with a pronounced elevation of the cloud-top heights above the Arica Bight at ∼20°S. Diurnal cloud-top height variations (inferred from irregular 4-times-daily sampling) can locally reach 250 m in amplitude, and they can help to visualize offshore propagation of free-tropospheric vertical motions. A shallow boundary layer associated with the Chilean coastal jet expands to its north and west in the afternoon. Cloud-top heights above the Arica Bight region are depressed in the afternoon, which may mean that increased subsidence from sensible heating of the Andes dominates an afternoon increase in convergence/upward motion at the exit of the Chilean coastal jet. In the southeast Atlantic during October, the stratocumulus cloud-top heights are typically lower than those in the southeast Pacific. A coastal jet region can also be identified through its low cloud-top heights. Coastal shoaling of the South Atlantic stratocumulus region is mostly uniform with latitude, in keeping with the more linear Namibian/Angolan coastline. The southeast Atlantic shallow cloudy boundary layer extends farther offshore than in the southeast Pacific, particularly at 15°S