Analysis of Global Radiotherapy Needs and Costs by Geographic Region and Income Level.

Recent years have seen various reviews on the lack of access to radiotherapy often based on geographic regions of the world such as Africa, Asia Pacific, Europe, Latin America and North America. Countries are often defined by their national income per capita levels based on World Bank definitions of high income, upper middle income, lower middle income and low income. Within the world regions, there are significant variations in gross national income (GNI) per capita among the different countries, and even within similar income levels, large variations exist. This report presents the actual status of radiotherapy and analyses the current needs and costs to provide full access in the different regions of the world. Actual coverage of the needs ranges from 34% in Africa to over 92% in Europe to about double the needs in North America. In line with this, proportional additional investments and operational costs are as high as more than 200% in Africa to almost none in North America. Two world regions face substantial challenges: Africa, based on the important demands to build new capacity and subsequently to maintain operational capability; and Asia Pacific, due to its high population density, translating into large absolute needs in radiotherapy treatments and resources, and hence in associated costs. With the data highlighting a large variability of GNI/capita even within similar income levels in the various world regions, it is expected that additional investment in resources and costs may be more dependent on income level of the country than on the GNI group or the geographic region of the world

Structure of the harmonic oscillator in the space of n-particle Glauber correlators

We map the Hilbert space of the quantum harmonic oscillator to the space of Glauber’s nth-order intensity correlators, in effect showing “the correlations between the correlators” for a random sampling of the quantum states. In particular, we show how the popular g(2) function is correlated to the mean population and how a recurrent criterion to identify single-particle states or emitters, namely, g(2)<1/2g(2)<1/2, actually identifies states with at most two particles on average. Our charting of the Hilbert space allows us to capture its structure in a simpler and physically more intuitive way that can be used to classify quantum sources by surveying which territory they can access

A Vehicle Simulation Model and Automated Driving Features Validation for Low-Speed High Automation Applications

The low-speed high automation (LSHA) is foreseen as a development path for new types of mobility, improving road safety and addressing transit problems in urban infrastructures. As these automation approaches are still in the development phase, methods to improve their design and validation are required. The use of vehicle simulation models allows reducing significantly the time deployment on real test tracks, which would not consider all the scenarios or complexity related to automated driving features. However, to ensure safety and accuracy while evaluating the proper operation of LSHA features, adequate validation methodologies are mandatory. In this study a two-step validation methodology is proposed: Firstly, an open-loop test set attempts to tune the required vehicle simulation models using experimental data considering also the dynamics of the actuation devices required for vehicle automation. Secondly, a closed-loop test strives to validate the selected automated driving functionality based on test plans, also improving the vehicle dynamics response. To illustrate the methodology, a study case is proposed using an automated Renault Twizy. In the first step, the brake pedal and steering wheel actuators' behavior is modeled, as well as its longitudinal dynamics and turning capacity. Then, in a second step, an LSHA functionality for Traffic Jam Assist based on a Model Predictive Control approach is evaluated and validated. Results demonstrate that the proposed methodology is capable not only to tune vehicle simulation models for automated driving development purposes but also to validate LSHA functionalities

First principles quasiparticle damping rates in bulk lead

First principles calculations of the damping rates (inverse inelastic lifetimes) of low energy quasiparticles in bulk Pb are presented. Damping rates are obtained both for excited electrons and holes with energies up to 8 eV on a set of k vectors throughout the Brillouin zone (BZ). Strong localization effects in the calculated lifetimes are found. Averaged over the BZ inelastic lifetimes versus quasiparticle energy are reported as well. In addition, the effect of the spin-orbit induced splitting in the band structure on the calculated lifetimes in Pb is investigated.Comment: 10 pages, 8 figures, 5 table

Matching for Several Sparse Nominal Variables in a Case-Control Study of Readmission Following Surgery.

Matching for several nominal covariates with many levels has usually been thought to be difficult because these covariates combine to form an enormous number of interaction categories with few if any people in most such categories. Moreover, because nominal variables are not ordered, there is often no notion of a close substitute when an exact match is unavailable. In a case-control study of the risk factors for read-mission within 30 days of surgery in the Medicare population, we wished to match for 47 hospitals, 15 surgical procedures grouped or nested within 5 procedure groups, two genders, or 47 × 15 × 2 = 1410 categories. In addition, we wished to match as closely as possible for the continuous variable age (65-80 years). There were 1380 readmitted patients or cases. A fractional factorial experiment may balance main effects and low-order interactions without achieving balance for high-order interactions. In an analogous fashion, we balance certain main effects and low-order interactions among the covariates; moreover, we use as many exactly matched pairs as possible. This is done by creating a match that is exact for several variables, with a close match for age, and both a near-exact match and a finely balanced match for another nominal variable, in this case a 47 × 5 = 235 category variable representing the interaction of the 47 hospitals and the five surgical procedure groups. The method is easily implemented in R

Exchange interaction and its tuning in magnetic binary chalcogenides

Using a first-principles Green's function approach we study magnetic properties of the magnetic binary chalcogenides Bi2Te3, Bi2Se3, and Sb2Te3. The magnetic coupling between transition-metal impurities is long-range, extends beyond a quintuple layer, and decreases with increasing number of d electrons per 3d atom. We find two main mechanisms for the magnetic interaction in these materials: the indirect exchange interaction mediated by free carriers and the indirect interaction between magnetic moments via chalcogen atoms. The calculated Curie temperatures of these systems are in good agreement with available experimental data. Our results provide deep insight into magnetic interactions in magnetic binary chalcogenides and open a way to design new materials for promising applications