An Analysis of Stomach Contents of the Ouachita Madtom in Three Streams of the Upper Saline River Drainage, Arkansas

A study was conducted to identify typical foods eaten by the Ouachita madtom (Noturus lachneri), an endemic ictalurid of central Arkansas, and to compare these foods to the invertebrate community. Fish and invertebrate samples were collected in August and October, 1990, from a pool and adjacent riffle habitat in each of 3 streams in the upper Saline River drainage. Kick-net and electrofishing samples were collected at each site and the invertebrate organisms were identified to the lowest possible taxa. Stomachs from the N. lachneri specimens were removed and the contents were identified to order. Frequency of occurrence of each taxon was compared between stomach contents and kick-net samples. Similarities between kick-net samples and stomach contents indicate that N. lachneri specimens were not highly selective in food preference in the riffle and pool habitats of these Ouachita Mountain streams

Regional-dependent intestinal absorption and meal composition effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs

Low oral bioavailability and a negative meal effect on drug plasma levels motivated studies on formulation and meal composition effects on the absorption of LY303366, a poorly water-soluble, semisynthetic, cyclic peptide antifungal drug. Solid drug particle size and meal composition studies were evaluated in beagle dogs. Canine regional absorption studies were also carried out utilizing surgically implanted intestinal access ports, and Caco-2 studies were performed to evaluate drug candidate intestinal permeability. Particle size and Caco-2 data indicate that drug permeability limitations to absorption are more important than dissolution rate limits. Caco-2 cell-associated LY303366 approached 10% of incubation concentration that is in the range of the oral bioavailability of the drug. Canine regional absorption studies showed that the extent of LY303366 absorption following duodenal administration was similar to that following oral administration. Significantly lower drug plasma levels were obtained following administration through a colonic access port, a result consistent with poor membrane permeation. Administration of drug with meals of mixed composition, as well as simple fat and protein meals, resulted in significant reductions in AUC 0–48h compared with results from fasted dogs. In contrast, carbohydrate meals did not reduce drug plasma levels compared to controls. Intravenous pretreatment with devazepide, a cholecystokinin (CCK) antagonist that blocks canine biliary secretion, did not reverse the negative effect of the fat meal on LY303366. Taken together, the results from the present study suggest that membrane-permeability-limited absorption is the cause of the observed regionally dependent absorption of LY303366 in the dog and that the observed negative meal effects depend on composition but are independent of biliary secretion. © 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 90:47–57, 2001Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34506/1/6_ftp.pd

Managing Quail in Arizona: Meeting New Challenges with Old Techniques

I present an overview of past quail management in Arizona and the current direction of Arizona’s Quail Program. Since the inception of Arizona’s quail management program, management activities progressed from an era of intensive population and habitat data collection and habitat improvements, to one of more passive management. I explore the reasons for the de-emphasis of field activities and active management, and will discuss the changing face of quail habitat and quail hunters in Arizona. I will also discuss quail management issues related to hunter recruitment and retention, and the current social climate that makes annual population data collection and more active habitat management activities both desirable and necessary

Outcomes of shared institutional review board compared with multiple individual site institutional review board models in a multisite clinical trial

Background: Institutional review boards play a crucial role in initiating clinical trials. Although many multicenter clinical trials use an individual institutional review board model, where each institution uses their local institutional review board, it is unknown if a shared (single institutional review board) model would reduce the time required to approve a standard institutional review board protocol. Objective: This study aimed to compare processing times and other processing characteristics between sites using a single institutional review board model and those using their individual site institutional review board model in a multicenter clinical trial. Study design: This was a retrospective study of sites in an open-label, multicenter randomized control trial from 2014 to 2021. Participating sites in the multicenter Chronic Hypertension and Pregnancy trial were asked to complete a survey collecting data describing their institutional review board approval process. Results: A total of 45 sites participated in the survey (7 used a shared institutional review board model and 38 used their individual institutional review board model). Most sites (86%) using the shared institutional review board model did not require a full-board institutional review board meeting before protocol approval, compared with 1 site (3%) using the individual institutional review board model (P<.001). Median total approval times (41 vs 56 days; P=.42), numbers of submission rounds (1 vs 2; P=.09), and numbers of institutional review board stipulations (1 vs 4; P=.12) were lower for the group using the shared institutional review board model than those using the individual site institutional review board model; however, these differences were not statistically significant. Conclusion: The findings supported the hypothesis that the shared institutional review board model for multicenter studies may be more efficient in terms of cumulative time and effort required to obtain approval of an institutional review board protocol than the individual institutional review board model. Given that these data have important implications for multicenter clinical trials, future research should evaluate these findings using larger or multiple multicenter trials