The Witness

I want to tell you a story. Why? I don\u27t know. Perhaps so that you will understand. Perhaps so that I will understand. It is a story of the present. It is a story that allows a little comprehension of the past. And it is a story that reveals glimpses of the future. First this preface: For years I have been drawn as if by a magnet to the subject of the Holocaust. I have read much about it, spoken to some who survived it, seen films on it, visited museums concerned with it. I have seen the faces of those who went through it. I have listened to their thoughts, their perceptions, and their approaches to life and existence in the face of it. I have seen their eyes. I have been drawn into their eyes, to their minds and hearts and souls. I have lived inside them, and they have lived inside me. I have been swept into the whirlwind made up of the cries, the sighs . . . the eyes of the six million. And yet , as much and as hard as I have tried, I cannot understand it. I cannot comprehend it. It is as a vague, illusory, fleeting wind, whirling, Whipping and moaning above me, which I can never really touch or see. It is as a dream, a mythology, a story which I can never really believe. Their reality is not my reality; it is only my imagination. And I stand alone, staring into their eyes, staring out from their eyes, trying to understand

Beastly Beatitudes (1): The Case of A Patient with Severe Borderline Personality Disorder

The newspapers, tabloids, and novels are filled with it. So are the television shows and movies. Sensationalism. The public can\u27 t get enough of it. A crazed killer stalks an innocent victim who is alone, isolated and helpless, and he brutally tortures her to death. Sound familiar? The case at hand is a fascinating one which, though perhaps surrounded by the trappings of such sensationalism, provides us with some insight into the inner workings of one patient \u27s tortured mind

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse

SEMANTIC DECOMPOSITION OF COMPUTER PROGRAMS: A PROGRAM TEST AID.

Abstract not availabl