1,219 research outputs found
Real Estate Equity Investments and the Institutional Lender: Nothing Ventured, Nothing Gained
We consider a setup in which the channel from Alice to Bob is less noisy than the channel from Eve to Bob. We show that there exist encoding and decoding which accomplish error correction and authentication simultaneously; that is, Bob is able to correctly decode a message coming from Alice and reject a message coming from Eve with high probability. The system does not require any secret key shared between Alice and Bob, provides information theoretic security, and can safely be composed with other protocols in an arbitrary context
Hall effect and magnetoresistance in single crystals of NdFeAsOF
Hall effect and magnetoresistance have been measured on single crystals of
with x = 0 ( = 0 K) and x = 0.18 ( = 50 K). For the undoped samples, strong Hall effect and magnetoresistance with
strong temperature dependence were found below about 150 K. The
magnetoresistance was found to be as large as 30% at 15 K at a magnetic field
of 9 T. From the transport data we found that the transition near 155 K was
accomplished in two steps: first one occurs at 155 K which may be associated
with the structural transition, the second one takes place at about 140 K which
may correspond to the spin-density wave like transition. In the superconducting
sample with = 50 K, it is found that the Hall coefficient also reveals
a strong temperature dependence with a negative sign. But the magnetoresistance
becomes very weak and does not satisfy the Kohler's scaling law. These
dilemmatic results (strong Hall effect and very weak magnetoresistance) prevent
to understand the normal state electric conduction by a simple multi-band model
by taking account the electron and hole pockets. Detailed analysis further
indicates that the strong temperature dependence of cannot be easily
understood with the simple multi-band model either. A picture concerning a
suppression to the density of states at the Fermi energy in lowering
temperature is more reasonable. A comparison between the Hall coefficient of
the undoped sample and the superconducting sample suggests that the doping may
remove the nesting condition for the formation of the SDW order, since both
samples have very similar temperature dependence above 175 K.Comment: 8 pages, 9 figure
EARLIER INTERVENTION IN TYPE 2 DIABETES
In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression
Efficacy and Safety of the Human Glucagon-Like Peptide-1 Analog Liraglutide in Combination With Metformin and Thiazolidinedione in Patients With Type 2 Diabetes (LEAD-4 Met+TZD)
OBJECTIVETo determine the efficacy and safety of liraglutide (a glucagon-like peptide-1 receptor agonist) when added to metformin and rosiglitazone in type 2 diabetes.RESEARCH DESIGN AND METHODSThis 26-week, double-blind, placebo-controlled, parallel-group trial randomized 533 subjects (1:1:1) to once-daily liraglutide (1.2 or 1.8 mg) or liraglutide placebo in combination with metformin (1 g twice daily) and rosiglitazone (4 mg twice daily). Subjects had type 2 diabetes, A1C 7–11% (previous oral antidiabetes drug [OAD] monotherapy ≥3 months) or 7–10% (previous OAD combination therapy ≥3 months), and BMI ≤45 kg/m2.RESULTSMean A1C values decreased significantly more in the liraglutide groups versus placebo (mean ± SE −1.5 ± 0.1% for both 1.2 and 1.8 mg liraglutide and −0.5 ± 0.1% for placebo). Fasting plasma glucose decreased by 40, 44, and 8 mg/dl for 1.2 and 1.8 mg and placebo, respectively, and 90-min postprandial glucose decreased by 47, 49, and 14 mg/dl, respectively (P < 0.001 for all liraglutide groups vs. placebo). Dose-dependent weight loss occurred with 1.2 and 1.8 mg liraglutide (1.0 ± 0.3 and 2.0 ± 0.3 kg, respectively) (P < 0.0001) compared with weight gain with placebo (0.6 ± 0.3 kg). Systolic blood pressure decreased by 6.7, 5.6, and 1.1 mmHg with 1.2 and 1.8 mg liraglutide and placebo, respectively. Significant increases in C-peptide and homeostasis model assessment of β-cell function and significant decreases in the proinsulin-to-insulin ratio occurred with liraglutide versus placebo. Minor hypoglycemia occurred more frequently with liraglutide, but there was no major hypoglycemia. Gastrointestinal adverse events were more common with liraglutide, but most occurred early and were transient.CONCLUSIONSLiraglutide combined with metformin and a thiazolidinedione is a well-tolerated combination therapy for type 2 diabetes, providing significant improvements in glycemic control
Proceedings of the 1997 Annual Meeting Association of American Law School Sections on Employment Discrimination Law and Alternative Dispute Resolution
The following is an edited transcript of the proceedings of the joint meeting of the Employment Discrimination Law and Alternative Dispute Resolution Sections at the AALS Annual Meeting, Washington, D.C., January 7, 1997
Impact of Maternal Physical Activity and Infant Feeding Practices on Infant Weight Gain and Adiposity
Increasing evidence supports the contribution of intrauterine environmental exposures on obesity risk in offspring. Few studies have included maternal and infant lifestyle factors. Our objective was to study the impact of maternal physical activity, infant feeding, and screen time on offspring weight gain and adiposity. In a prospective cohort study, 246 mothers underwent testing during pregnancy to assess glucose tolerance status and insulin sensitivity. Anthropometry and questionnaires on physical activity, infant feeding, and screen time were completed. Multiple-linear regression was performed to examine the impact of maternal and infant factors on infant weight gain and weight-for-length z-score at 1 year. Infant weight outcomes were negatively predicted by maternal pregravid vigorous/sport index and exclusive breastfeeding duration. After adjustment, each unit increase in maternal pregravid vigorous/sport index decreased infant weight gain by 218.6 g (t=2.44, P=0.016) and weight-for-length z-score by 0.20 (t=2.17, P=0.031). Each month of exclusive breastfeeding reduced infant weight gain by 116.4 g (t=3.97, P<0.001) and weight-for-length z-score by 0.08 (t=2.59, P=0.01). Maternal pregravid physical activity and exclusive breastfeeding duration are associated with weight gain and adiposity as early as 1 year of age
Five-year impacts of group-based financial education and savings promotion for Ugandan youth
This is the author accepted manuscript. The final version is available from MIT Press via the DOI in this recordWe experimentally evaluate group-based financial education, savings account access, or both for members of Ugandan youth groups. We measure both short- and long-run impacts with one- and five- year endline household surveys. Education, but not account access, increases measured financial knowledge and trust at one-year. At five-years, knowledge effects essentially disappear, and trust effects weaken. However, savings and income increase for each treatment at both endlines, which is noteworthy given the interventions’ low cost and the long time horizon of our second endline. Exploring potential mechanisms, we find evidence consistent with multiple pathways to behavior change and outcome improvement.DFIDCiti Foundatio
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