Wound-healing potentiation in mice treated with phenolic extracts of Moringa oleifera leaves planted at different climatic areas

For years, Moringa oleifera has been known for possessing wound-healing properties. This study aimed to investigate the effect of two extracts: aqueous extract (AE) and ethanolic extract (EE) of Moringa oleifera leaves planted at two regions (Mssisi and Lamta) in Morocco for their anti-inflammatory and healing properties, for which mice were used as a biological model. Inflammation was monitored by assessing forepaw volume of mice, measured at 0 min, 1 h, 3 h, and 5 h, after its induction by carrageenan. Hind paw of mice were treated with extracts of M. oleifera, at a dose of 50 mg/kg, obtained from Mssisi region. This resulted in reduction of edema by 99.2% with EE and by 91.8% with AE, compared to controls and the phenolic extract of M. oleifera planted at Lamta region. Regarding healing of burns induced on rat’s dorsal region; results showed that application of Moringa-based ointment for 14 days, at a dose of 50 mg/kg on wounds, resulted in total healing, compared to controls (negative control: more than 22 days, and positive control: 22 days). M. oleifera extracts resulted in nearly complete tissue repair of 98.26% and 95.34% with EE and AE, respectively.info:eu-repo/semantics/publishedVersio

Determination of zearalenone and its metabolites in endometrial cancer by coupled separation techniques

This study presents a selective method of isolation of zearalenone (ZON) and its metabolite, α-zearalenol (α-ZOL), in neoplastically changed human tissue by accelerated solvent and ultrasonic extractions using a mixture of acetonitrile/water (84/16% v/v) as the extraction solvent. Extraction effectiveness was determined through the selection of parameters (composition of the solvent mixture, temperature, pressure, number of cycles) with tissue contamination at the level of nanograms per gram. The produced acetonitrile/water extracts were purified, and analytes were enriched in columns packed with homemade molecularly imprinted polymers. Purified extracts were determined by liquid chromatography (LC) coupled with different detection systems (diode array detection - DAD and mass spectrometry - MS) involving the Ascentis RP-Amide as a stationary phase and gradient elution. The combination of UE-MISPE-LC (ultrasonic extraction - molecularly imprinted solid-phase extraction - liquid chromatography) produced high (R ≈ 95–98%) and repeatable (RSD < 3%) recovery values for ZON and α-ZOL

Towards a context-driven platform using IoT and big data technologies for energy efficient buildings

International audienceContext-awareness is crucial for leveraging energy-efficient buildings by developing intelligent control approaches in which sensing and actuation tasks are performed according to the contextual changes. This could be done by including the users' actions and behaviours in up-to-date context taking into account the complex interlinked elements, situations, processes, and their dynamics. In this paper, we introduce a holistic platform that integrates recent sensing/actuating and Big data technologies for monitoring and data processing. The main aim is to develop context-driven control approaches whereby energy consumption, production, and storage could be controlled according to actual situations (e.g., occupancy, occupant behaviour patterns, energy production patterns, and weather data). A platform prototype was deployed in our university test site. Experiments have been conducted and preliminary results show the usefulness of this holistic platform for monitoring and data processing in energy efficient buildings