The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study

Background. Previous studies reported the controvertible association between red blood cell distribution width (RDW) and diabetes. The aim of this study is to explore whether RDW is associated with incident diabetes. Methods. We performed this cohort study in 16,971 Chinese adults (9,956 men and 7,015 women, aged 43.3±12.8 years). The level of RDW was measured at baseline (2014). All the participants were further classified into four quartile groups based on baseline RDW. Fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) were measured annually during follow-up (2014-2019). Diabetes was diagnosed if either FBG≥7.0 mmol/L or HbA1c≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between baseline RDW and incident diabetes. Results. We identified 2,703 new cases of diabetes during five-year follow-up. The incidence was 15.9%. Comparing with participants in the lowest quartile group (reference group), the adjusted hazard ratios (HR) for the risk of diabetes were 1.31 (95% CI: 1.16, 1.48) for the highest quartile group (p trend<0.001), after adjustment for potential confounders. Further adjusting baseline FBG and HbA1c did not materially change the association between RDW and incident diabetes. Each unit increase of RDW was associated with a 16% higher risk of incident diabetes (HR=1.16, 95% CI: 1.06, 1.26) in a fully adjusted model. Sensitivity analysis generated similar results with prospective analyses after excluding aged participants, participants who are overweight and with obesity, participants with elevated blood pressure, participants with decreased eGFR, and those with anemia at baseline. Conclusions. High RDW was associated with high risk of developing diabetes in Chinese adults. As RDW is an inexpensive, noninvasive, and convenient indicator, RDW might be considered for inclusion in the risk assessment of high-risk groups of diabetes

Tunable V-cavity laser based on half-wave multimode interference reflector

We report a tunable V-cavity laser based on half-wave multimode interference reflector. Wavelength tuning of 39 channels is obtained with side mode suppression ratio around 38dB and the output power can reach 14mW

Monolithically Integrated 8 &#x00D7; 8 Transmitter-Router Based on Tunable V-Cavity Laser Array and Cyclic Arrayed Waveguide Grating Router

A monolithic 8 &#x00D7; 8 transmitter-router chip fabricated on InGaAlAs-InP multi-quantum well wafer for distributed wavelength routing network in the O-band with a channel spacing of 400 GHz is experimentally demonstrated. A tunable V-cavity laser (VCL) array, a cyclic-arrayed waveguide grating router (AWGR) and a semiconductor amplifier (SOA) array are integrated using the quantum-well intermixing (QWI) technique for its fabrication simplicity and cost effectiveness. A 200 GHz-spaced compact-size VCL is demonstrated with a 27 nm tuning range and a side-mode suppression ratio (SMSR) around 40 dB using a single-electrode controlled tuning. The chip output power is 24.6 mW. Measurement results of the transmitter-router chip show that all 64 input-output combinations have cyclic response spectra. After passing through the SOA with 80 mA bias current, an output power of about 9.6 mW and optical signal-to-noise ratio (OSNR) up to 39 dB have been measured. The demonstrated transmitter-router chip is fabricated on the same quantum well structure without requiring multiple epitaxial growth and complex grating fabrication. The characteristics of multi-wavelength and multi-port transmissions enable the distributed optical routing networks with flexible bandwidth allocation, which can find wide application in datacenters and high-performance computers

Serum Renalase Levels Correlate with Disease Activity in Lupus Nephritis.

Lupus nephritis (LN) is among the most serious complications of systemic lupus erythematosus (SLE), which causes significant morbidity and mortality. Renalase is a novel, kidney-secreted cytokine-like protein that promotes cell survival. Here, we aimed to investigate the relationship of serum renalase levels with LN and its role in the disease progression of LN.For this cross-sectional study, 67 LN patients and 35 healthy controls were enrolled. Seventeen active LN patients who received standard therapies were followed up for six months. Disease activity was determined by the SLE Disease Activity-2000 (SLEDAI-2K) scoring system and serum renalase amounts were determined by ELISA. Predictive value of renalase for disease activity was assessed. Furthermore, the expression of renalase in the kidneys of patients and macrophage infiltration was assessed by immunohistochemistry.Serum renalase amounts were significantly higher in LN patients than in healthy controls. Moreover, patients with proliferative LN had more elevated serum renalase levels than Class V LN patients. In proliferative LN patients, serum renalase levels were significantly higher in patients with active LN than those with inactive LN. Serum renalase levels were positively correlated with SLEDAI-2K, 24-h urine protein excretion, ds-DNA and ESR but inversely correlated with serum albumin and C3. Renalase amounts decreased significantly after six-months of standard therapy. The performance of renalase as a marker for diagnosis of active LN was 0.906 with a cutoff value of 66.67 μg/ml. We also observed that the amount of renalase was significantly higher in glomerular of proliferative LN along with the co-expression of macrophages.Serum renalase levels were correlated with disease activity in LN. Serum renalase might serve as a potential indicator for disease activity in LN. The marked increase of glomerular renalase and its association with macrophages suggest that it might play an important role in disease progression of LN

Clinical characteristics of LN patients and healthy controls.

<p>SBP, systolic blood pressure; DBP, diastolic blood pressure; WBC, white blood cell; eGFR, estimated glomerular filtration rate; ESR, erythrocyte sedimentation rate; hs-CRP, high sensitive C reaction protein; TG, total glycerin; TC, total cholesterol; HDL, high density lipoprotein; LDL, low density lipoprotein; ds-DNA, double strain DNA.</p><p>Clinical characteristics of LN patients and healthy controls.</p