Quantifying Spatiotemporal Dynamics of Solar Radiation over the Northeast China Based on ACO-BPNN Model and Intensity Analysis

Reliable information on the spatiotemporal dynamics of solar radiation plays a crucial role in studies relating to global climate change. In this study, a new backpropagation neural network (BPNN) model optimized with an Ant Colony Optimization (ACO) algorithm was developed to generate the ACO-BPNN model, which had demonstrated superior performance for simulating solar radiation compared to traditional BPNN modelling, for Northeast China. On this basis, we applied an intensity analysis to investigate the spatiotemporal variation of solar radiation from 1982 to 2010 over the study region at three levels: interval, category, and conversion. Research findings revealed that (1) the solar radiation resource in the study region increased from the 1980s to the 2000s and the average annual rate of variation from the 1980s to the 1990s was lower than that from the 1990s to the 2000s and (2) the gains and losses of solar radiation at each level were in different conditions. The poor, normal, and comparatively abundant levels were transferred to higher levels, whereas the abundant level was transferred to lower levels. We believe our findings contribute to implementing ad hoc energy management strategies to optimize the use of solar radiation resources and provide scientific suggestions for policy planning

Development and validation of nomogram models to discriminate between acute aortic syndromes and non-ST-elevation myocardial infarction during troponin-blind period

BackgroundBlood-test-based methods of distinguishing between acute aortic syndromes (AASs) and non-ST-elevation myocardial infarction (NSTEMI) during the troponin-blind period of <2–3 h of symptom onset have not been studied previously. We aimed to explore whether routine biomarkers might facilitate differential diagnosis.MethodsData were retrospectively collected from 178 patients with AASs and 460 patients with NSTEMI within 3 h of onset. Differential risk factors related to AASs were identified by univariate and multivariate logistic regression analyses for patients with onset <2 h and onset ≥2 h, respectively, in the cardiac troponin (cTn) cohort. Nomograms were established in the cTn cohort as a training set and validated in the high-sensitivity cTn cohort. To assess the utility of the models in clinical practice, decision curve analyses were performed.ResultsD-dimer, fibrinogen, and age were identified as differential risk factors for AASs with the onset of <2 h. D-dimer at an optimal cutoff level of 281 ng/mL for AASs had a sensitivity of 86.4% and a specificity of 91.3%. A nomogram was developed and validated with areas under the curve (AUC) of 0.934 (95% CI: 0.880–0.988) and 0.952 (95% CI: 0.874–1.000), respectively. D-dimer, neutrophil, bilirubin, and platelet were the differential risk factors for AASs with the onset of ≥2 h. D-dimer at an optimal cutoff level of 385 ng/mL has a sensitivity of 91.8% and a specificity of 91.3%. The AUC of the second nomogram in the training set and the validation set were 0.965 (95% CI: 0.942–0.988) and 0.974 (95% CI: 0.944–1.000), respectively.ConclusionTime-dependent quality of D-dimer should be considered for discriminating AASs from NSTEMI. Both nomogram models may have a clinical utility for evaluating the probability of AASs

Quantifying evolution of soot mixing state from transboundary transport of biomass burning emissions

Incomplete combustion of fossil fuels and biomass burning emit large amounts of soot particles into the troposphere. The condensation process is considered to influence the size (Dp) and mixing state of soot particles, which affects their solar absorption efficiency and lifetimes. However, quantifying aging evolution of soot remains hampered in the real world because of complicated sources and observation technologies. In the Himalayas, we isolated soot sourced from transboundary transport of biomass burning and revealed soot aging mechanisms through microscopic observations. Most of coated soot particles stabilized one soot core under Dp &lt; 400 nm, but 34.8% of them contained multi-soot cores (nsoot ≥ 2) and nsoot increased 3–9 times with increasing Dp. We established the soot mixing models to quantify transformation from condensation- to coagulation-dominant regime at Dp ≈ 400 nm. Studies provide essential references for adopting mixing rules and quantifying the optical absorption of soot in atmospheric models.</p

The mechanism of resistance-reducing/anti-adhesion and its application on biomimetic disc furrow opener

The black soil of Northeast China is sticky and agglomerates easily, which often adheres to the surface of a traditional furrow opener during the furrowing process. In this paper, biomimetic design principles in resistance-reducing, anti-adhesion and resistance-reducing mechanism of biomimetic disc furrow opener were studied. Nine kinds of singular convex hull, nine kinds of singular wedge and nine kinds of mixed convex hull and wedge structural biomimetic disc furrow opener were designed, and the furrowing process with the soil simulated by finite element method (FEM). Three types of biomimetic disc furrow opener with less resistance were manufactured by laser processing for comparative test in soil bin based on the simulation results. The test results showed that the resistance of the biomimetic disc furrow opener was less than that of the ordinary disc. The soil-disc stress, influence of biomimetic structures, moisture content and furrow speeds on resistance were discussed. The resistance-reducing rate of D-BC-3 reached the maximum value 15.36% at the furrow speed of 0.6 m/s and the soil moisture content of 20%. It is believed that the biomimetic design principles can provide the significant inspirations for the future design of disc furrow opener with drag reduction

An AT-hook gene is required for palea formation and floral organ number control in rice

AbstractGrasses have highly specialized flowers and their outer floral organ identity remains unclear. In this study, we identified and characterized rice mutants that specifically disrupted the development of palea, one of the outer whorl floral organs. The depressed palea1 (dp1) mutants show a primary defect in the main structure of palea, implying that palea is a fusion between the main structure and marginal tissues on both sides. The sterile lemma at the palea side is occasionally elongated in dp1 mutants. In addition, we found a floral organ number increase in dp1 mutants at low penetration. Both the sterile lemma elongation and the floral organ number increase phenotype are enhanced by the mutation of an independent gene SMALL DEGENERATIVE PALEA1 (SDP1), whose single mutation causes reduced palea size. E function and presumable A function floral homeotic genes were found suppressed in the dp1–2 mutant. We identified the DP1 gene by map-based cloning and found it encodes a nuclear-localized AT-hook DNA binding protein, suggesting a grass-specific role of chromatin architecture modification in flower development. The DP1 enhancer SDP1 was also positional cloned, and was found identical to the recently reported RETARDED PALEA1 (REP1) gene encoding a TCP family transcription factor. We further found that SDP1/REP1 is downstreamly regulated by DP1

Enhanced HMGB1 Expression May Contribute to Th17 Cells Activation in Rheumatoid Arthritis

Rheumatoid arthritis(RA) is a common autoimmune disease associated with Th17 cells, but what about the effect of high-mobility group box chromosomal protein 1 (HMGB1) and the relationship between Th17-associated factors and HMGB1 in RA remains unknown. In the present study, we investigated the mRNA levels of HMGB1, RORγt, and IL-17 in peripheral blood mononuclear cells (PBMCs) from patients with rheumatoid arthritis by quantitative real-time PCR (RT-qPCR), and the concentrations of HMGB1, IL-17, and IL-23 in plasma were detected by ELISA. And then, the effect of HMGB1 on Th17 cells differentiation was analyzed in vitro. Our clinical studies showed that the mRNAs of HMGB1, RORγt, and IL-17 in patients were higher than that in health control (P < 0.05), especially in active RA patients (P < 0.05). The plasma HMGB1, IL-17, and IL-23 in RA patients were also higher than that in health control (P < 0.05); there was a positive correlation between the expression levels of HMGB1 and the amount of CRP, ERS, and RF in plasma. In vitro, the IL-17-produced CD4+T cells were increased with 100 ng/mL rHMGB1 for 12h, which indicated that the increased HMGB1 might contribute to Th17 cells activation in RA patients

Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis

Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of autoimmune disease. So far, only one study investigated the circulating Tfh cells increased in a subset of SLE patients. Since relatively little is known about the Tfh cells in rheumatoid arthritis (RA) patients, in this study, Tfh-cell frequency, related cytokine IL-21, and transcription factor Bcl-6 were investigated in 53 patients with RA and 31 health controls. Firstly, we found that the frequency of CD4+CXCR5+ICOShigh Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. It is known that Tfh cells are critical for directing the development of an antibody response by germinal centers B cells; secondly, we observed that the Tfh-cell frequency is accompanied by the level of anti-CCP antibody in RA patients. Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in RA patients was increased. Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA

Manipulating Multiple Order Parameters via Oxygen Vacancies: The case of Eu0.5Ba0.5TiO3-{\delta}

Controlling functionalities, such as magnetism or ferroelectricity, by means of oxygen vacancies (VO) is a key issue for the future development of transition metal oxides. Progress in this field is currently addressed through VO variations and their impact on mainly one order parameter. Here we reveal a new mechanism for tuning both magnetism and ferroelectricity simultaneously by using VO. Combined experimental and density-functional theory studies of Eu0.5Ba0.5TiO3-{\delta}, we demonstrate that oxygen vacancies create Ti3+ 3d1 defect states, mediating the ferromagnetic coupling between the localized Eu 4f7 spins, and increase an off-center displacement of Ti ions, enhancing the ferroelectric Curie temperature. The dual function of Ti sites also promises a magnetoelectric coupling in the Eu0.5Ba0.5TiO3-{\delta}.Comment: Accepted by Physical Review B, 201