Randomly Generating the 3D Mesostructure of Soil Rock Mixtures Based on the Full In Situ Digital Image Processed Information

Understanding the occurrence and evolution of geological disasters, such as landslides and debris flows, is facilitated by research on the performance of soil rock mixes (SRM). Recently, more and more researchers have been interested in studying the mesostructure reconstruction process of SRM. The present mesostructure generation approaches, however, have several weaknesses. One of the weaknesses is that they do not consider the impact of particle shape and therefore cannot ensure similarity to the in situ SRMs. In this study, a new mesostructure generation method that randomly generates SRMs based on the full in situ digital image processing (DIP) information is proposed. The generation procedure of the proposed algorithm considers the geometry characteristics of in situ SRMs, including the size distribution, particle shape, and 2D fractal dimension of the cross-section. A parametric study was performed to examine how the rock content and particle shape affected the fractal dimension of the generated SRMs. The results indicate that as the rock content increases in intensity, the fractal dimension also increases. Only when the angular particle content is less than 75% does it affect the fractal dimension. The fractal dimension of the generated mesostructures increases with the increase in the angular particle proportion under the same rock content

Slope Stability Analysis Considering Sliding Effect of Upper Body

Owing to the human engineering activities, the phenomenon that new landslide happen on the upper part of the old sliding body can be found everywhere. This kind of slope consisting of two sliding bodies, which are upper body and lower body, is named as double-sliding-body slope. Its stability is usually analyzed according to two slopes. However, the effect of new landslide movement on the stability of entire slope system is not taken into account. In this paper, sliding effect of upper body is analyzed, and the formula considering sliding effect of upper body is derived based on Sarma method for analysis of entire slope. Theoretical analysis and a case history indicate that the spasmodic motion of upper body has bad effect on the lower body stability; Sliding along the top face of lower body, the effect on the lower body is disadvantageous during starting instant. Nevertheless, the bad effect will disappear and transform as the advantageous effect as descending of the slope gradient and sliding acceleration. For the slope controlling, the sliding effect of upper body should be considered in the stability analysis of double-sliding-body slope, thus it will help us recognizing and mastering or forecasting the evaluative trend of double-siding-body slope. Further reliable scientific basis can be provided in order to make effective controlling measures.特集 : 「資源、新エネルギー、環境、防災研究国際セミナー

深部軟岩坑道用ハイコンベックス・ストリップボルトを用いた複合支保技術に関する研究

Based on the systematic analysis of mechanical characteristics for deep roadway excavated in soft strata, the high convex strip-bolting support technology was put forward, and a numerical analysis was carried out by FLAC3D. The process of general bolting support and high convex strip-bolting support of deep soft rock roadway were simulated. The results indicate that the convex bed of strip-band can adapt to large deformation of high pre-stressed bolting, and the high strength and high rigidity of strip can bear large axial force and moment of flexion. In addition, bolting and anchoring combined support can control the deformation of rock masses by transferring the strength of deep strata, and bolt-grouting can form stress-relief region in deep and generates high strength invert arch at shallow which can afford some support resistances. A case study is also presented and the results of field measurement show that the new support system is suitable for roadways excavated in weak rocks.特集 : 「資源、新エネルギー、環境、防災研究国際セミナー

An in-situ modification method for coal roadways with heightened burst risk

It is hard to control roadways effectively with a heightened burst risk using conventional support techniques, which may cause burst fatalities in the coal mine. Thus, an in-situ modification method, which involves artificially constructing a cracked zone and a reinforced zone, was proposed to improve the stability of the roadways with heightened burst risk. This paper investigated the efficiency to non of the in-situ modification method in improving burstroadway safety by performing a physical experiment. The results of the experiment indicated that the dynamic stress was obviously reduced in the modified roadway. Accordingly, the influence factors of the in-situ modification method were explored using numerical simulation. It was found that the thickness and the degree of damage to the cracked zone were key governing factors in reducing energy and improving roadway stability. The energy dissipation value increased as the thickness and the degree of damage to the cracked zone increased but showed a slower growth trend when the thickness and the degree of damage to the cracked zone increased to a certain value. In addition, the high sensitivity to dynamic load was found in parts of the roadway side exhibiting a larger stress reduction rate even with thinner cracked zone thickness and a lower degree of damage. This research provides an effective and economical method for coal roadways with heightened burst risk

Geographical patterns and environmental influencing factors of variations in Asterothamnus centraliasiaticus seed traits on Qinghai-Tibetan plateau

IntroductionSeed traits related to recruitment directly affect plant fitness and persistence. Understanding the key patterns and influencing factors of seed trait variations is conducive to assessing plant colonization and habitat selection. However, the variation patterns of the critical seed traits of shrub species are usually underrepresented and disregarded despite their vital role in alpine desert ecosystems.MethodsThis study gathered seeds from 21 Asterothamnus centraliasiaticus populations across the Qinghai-Tibetan Plateau, analyzing geographical patterns of seed traits to identify external environmental influences. Additionally, it explored how seed morphology and nutrients affect germination stress tolerance, elucidating direct and indirect factors shaping seed trait variations.ResultsThe results present substantial intraspecific variations in the seed traits of A. centraliasiaticus. Seed traits except seed length-to-width ratio (LWR) all vary significantly with geographic gradients. In addition, the direct and indirect effects of climatic variables and soil nutrients on seed traits were verified in this study. Climate mainly influences seed nutrients, and soil nutrients significantly affect seed morphology and seed nutrients. Furthermore, climate directly impacts seed germination drought tolerance index (GDTI) and germination saline-alkali tolerance index (GSTI). Seed germination cold tolerance index (GCTI) is influenced by climate and soil nutrients (mostly SOC). GDTI and GSTI are prominently influenced by seed morphology (largely the seed thousand-grain weight (TGW)), and GCTI is evidently affected by seed nutrients (mainly the content of soluble protein (CSP)).DiscussionThe findings of this study amply explain seed trait variation patterns of shrubs in alpine desert ecosystems, possessing significant importance for understanding the mechanism of shrub adaptation to alpine desert ecosystems, predicting the outcomes of environmental change, and informing conservation efforts. This study can be a valuable reference for managing alpine desert ecosystems on the Qinghai-Tibetan Plateau

Association between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease

Background Only a subset of patients with excessive alcohol use develop alcoholic liver disease (ALD); though the exact mechanism is not completely understood. Once ingested, alcohol is metabolized by 2 key oxidative enzymes, alcohol (ADH) and aldehyde dehydrogenase (ALDH). There are 2 major ALDH isoforms, cytosolic and mitochondrial, encoded by the aldehyde ALDH1 and ALDH2 genes, respectively. The ALDH2 gene was hypothesized to alter genetic susceptibility to alcohol dependence and alcohol-induced liver diseases. The aim of this study is to determine the association between aldehyde dehydrogenase 2 (rs671) glu504lys polymorphism and ALD. Methods ALDH2 genotype was performed in 535 healthy controls and 281 patients with ALD. Results The prevalence of the common form of the SNP rs671, 504glu (glu/glu) was significantly higher in patients with ALD (95.4%) compared to that of controls (73.7%, p<0.0001). Among controls, 23.7% had heterozygous (glu/lys) genotype when compared to 4.6% in those with ALD (OR 0.16, 95%CI 0.09–0.28). The allele frequency for 504lys allele in patients with ALD was 2.3%; compared to 14.5% in healthy controls (OR 0.13, 95%CI 0.07–0.24). Conclusions Patients with ALDH2 504lys variant were less associated with ALD compared to those with ALDH2 504glu using both genotypic and allelic analyses

MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression

10.1371/journal.pone.0041523PLoS ONE78