Learning to Detect Noisy Labels Using Model-Based Features

Label noise is ubiquitous in various machine learning scenarios such as self-labeling with model predictions and erroneous data annotation. Many existing approaches are based on heuristics such as sample losses, which might not be flexible enough to achieve optimal solutions. Meta learning based methods address this issue by learning a data selection function, but can be hard to optimize. In light of these pros and cons, we propose Selection-Enhanced Noisy label Training (SENT) that does not rely on meta learning while having the flexibility of being data-driven. SENT transfers the noise distribution to a clean set and trains a model to distinguish noisy labels from clean ones using model-based features. Empirically, on a wide range of tasks including text classification and speech recognition, SENT improves performance over strong baselines under the settings of self-training and label corruption

A Retrotransposon Insertion in the 5' Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth’s Short Tail Mouse

Danforth's short tail mutant (Sd) mouse, first described in 1930, is a classic spontaneous mutant exhibiting defects of the axial skeleton, hindgut, and urogenital system. We used meiotic mapping in 1,497 segregants to localize the mutation to a 42.8-kb intergenic segment on chromosome 2. Resequencing of this region identified an 8.5-kb early retrotransposon (ETn) insertion within the highly conserved regulatory sequences upstream of Pancreas Specific Transcription Factor, 1a (Ptf1a). This mutation resulted in up to tenfold increased expression of Ptf1a as compared to wild-type embryos at E9.5 but no detectable changes in the expression levels of other neighboring genes. At E9.5, Sd mutants exhibit ectopic Ptf1a expression in embryonic progenitors of every organ that will manifest a developmental defect: the notochord, the hindgut, and the mesonephric ducts. Moreover, at E 8.5, Sd mutant mice exhibit ectopic Ptf1a expression in the lateral plate mesoderm, tail bud mesenchyme, and in the notochord, preceding the onset of visible defects such as notochord degeneration. The Sd heterozygote phenotype was not ameliorated by Ptf1a haploinsufficiency, further suggesting that the developmental defects result from ectopic expression of Ptf1a. These data identify disruption of the spatio-temporal pattern of Ptf1a expression as the unifying mechanism underlying the multiple congenital defects in Danforth's short tail mouse. This striking example of an enhancer mutation resulting in profound developmental defects suggests that disruption of conserved regulatory elements may also contribute to human malformation syndromes

Clinical and radiological characteristics of pediatric COVID-19 before and after the Omicron outbreak: a multi-center study

IntroductionThe emergence of the Omicron variant has seen changes in the clinical and radiological presentations of COVID-19 in pediatric patients. We sought to compare these features between patients infected in the early phase of the pandemic and those during the Omicron outbreak.MethodsA retrospective study was conducted on 68 pediatric COVID-19 patients, of which 31 were infected with the original SARS-CoV-2 strain (original group) and 37 with the Omicron variant (Omicron group). Clinical symptoms and chest CT scans were examined to assess clinical characteristics, and the extent and severity of lung involvement.ResultsPediatric COVID-19 patients predominantly had normal or mild chest CT findings. The Omicron group demonstrated a significantly reduced CT severity score than the original group. Ground-glass opacities were the prevalent radiological findings in both sets. The Omicron group presented with fewer symptoms, had milder clinical manifestations, and recovered faster than the original group.DiscussionThe clinical and radiological characteristics of pediatric COVID-19 patients have evolved with the advent of the Omicron variant. For children displaying severe symptoms warranting CT examinations, it is crucial to weigh the implications of ionizing radiation and employ customized scanning protocols and protective measures. This research offers insights into the shifting disease spectrum, aiding in the effective diagnosis and treatment of pediatric COVID-19 patients

Sp1 Is Essential for p16(INK4a) Expression in Human Diploid Fibroblasts during Senescence

BACKGROUND: p16 (INK4a) tumor suppressor protein has been widely proposed to mediate entrance of the cells into the senescent stage. Promoter of p16 (INK4a) gene contains at least five putative GC boxes, named GC-I to V, respectively. Our previous data showed that a potential Sp1 binding site, within the promoter region from −466 to −451, acts as a positive transcription regulatory element. These results led us to examine how Sp1 and/or Sp3 act on these GC boxes during aging in cultured human diploid fibroblasts. METHODOLOGY/PRINCIPAL FINDINGS: Mutagenesis studies revealed that GC-I, II and IV, especially GC-II, are essential for p16 (INK4a) gene expression in senescent cells. Electrophoretic mobility shift assays (EMSA) and ChIP assays demonstrated that both Sp1 and Sp3 bind to these elements and the binding activity is enhanced in senescent cells. Ectopic overexpression of Sp1, but not Sp3, induced the transcription of p16 (INK4a). Both Sp1 RNAi and Mithramycin, a DNA intercalating agent that interferes with Sp1 and Sp3 binding activities, reduced p16 (INK4a) gene expression. In addition, the enhanced binding of Sp1 to p16 (INK4a) promoter during cellular senescence appeared to be the result of increased Sp1 binding affinity, not an alteration in Sp1 protein level. CONCLUSIONS/SIGNIFICANCE: All these results suggest that GC- II is the key site for Sp1 binding and increase of Sp1 binding activity rather than protein levels contributes to the induction of p16 (INK4a) expression during cell aging

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The SIRT1, mammalian homologue of Sir2, regulates signaling for favoring survival in stress. But whether SIRT1 has the function to influence cell viability and senescence under non-stressed conditions in human diploid fibroblasts is far from unknown. Our data showed that enforced SIRT1 expression promoted cell proliferation and antagonized cellular senescence with the characteristic features of delayed Senescence-Associated β-galactosidase (SA-β-gal) staining, reduced Senescence-Associated Heterochromatic Foci (SAHF) formation and G1 phase arrest, increased cell growth rate and extended cellular lifespan in human fibroblasts, while dominant-negative SIRT1 allele (H363Y) did not significantly affect cell growth and senescence but displayed a bit decreased lifespan.. Western blot results showed that SIRT1 reduced the expression of p16INK4A and promoted phosphorylation of Rb. Our data also exposed that overexpression of SIRT1 was accompanied by enhanced activation of ERK and S6K1 signaling. These effects were mimicked in both WI38 cells and 2BS cells by concentration-dependent resveratrol, a SIRT1 activator. It was noted that treatment of SIRT1-.transfected cells with Rapamycin, a mTOR inhibitor, reduced the phosphorylation of S6K1 and the expression of Id1, implying that SIRT1-induced phosphorylation of S6K1 may be partly for the decreased expression of p16INK4A and promoted phosphorylation of Rb in 2BS. It was also observed that the expression of SIRT1 and phosphorylation of ERK and S6K1 was declined in senescent 2BS. These findings suggested that SIRT1-promoted cell proliferation and antagonized cellular senescence in human diploid fibroblasts may be, in part, via the activation of ERK/ S6K1 signaling

Cooperative Green Technology Innovation of an E-Commerce Sales Channel in a Two-Stage Supply Chain

The potential broad market of green consumption has encouraged an increasing number of enterprises to carry out green technology innovation activities. This paper examines a two-stage supply chain of e-commerce sales channels under different cooperative models. We find that consumers’ green preferences are the main factor that affects green product market demand. The manufacturer and the retailer can raise the levels of green technology innovation and extend green promotional services to expand product market demand in online and offline channels. However, consumers’ e-commerce preferences and online free-riding behaviors affect the manufacturer’s sales channel choice. The retailer can improve the level of green promotional services to hold offline channel market demand, while promotional behaviors have a positive/negative spillover effect on online market demand if the level of free riding falls above/below consumers’ e-commerce preferences. The higher the cooperative level is, the later the manufacturer will open the online channel and close the offline channel to ensure a high level of green promotional service from the cooperative retailer. The results show that the stronger the level of cooperation among all members is, the better the economic, ecological, and social benefits will be. Therefore, we design a revenue-cost sharing contract that can effectively motivate green technology innovation and green promotional services and afford all members win-win profits

Parametric Analysis and Optimization for Thermal Efficiency Improvement in a Turbocharged Diesel Engine with Peak Cylinder Pressure Constraints

While the original equipment manufacturers are developing engines that can withstand higher PCP, the methodology to maximize the thermal efficiency gain with different PCP limits is still not well-known or documented in the literature. This study aims to provide guidance on how to co-optimize air system parameters, compression ratio, and intake valve closing (IVC) timing of heavy-duty turbocharged diesel engines to enhance thermal efficiency with peak cylinder pressure (PCP) constraints. In this study, a one-dimensional turbocharged engine model is established and validated by experimental data. The effects of turbocharger efficiency, boost pressure, high-pressure exhaust gas recirculation (HP EGR) ratio, compression ratio (CR), and IVC timing on diesel engine efficiency are assessed under PCP constraints through parametric analysis. The results indicate that for enhancing engine thermal efficiency under limited PCP, an increment in boost pressure and CR, and late IVC timing compared to baseline is required. By multiple parameter optimization, the best parameter combination under different PCP constraints is proposed. At a PCP limit of 20 MPa, the combination of a compression ratio of 18.57, boost pressure of 298 kPa, and IVC timing of −95.2 °CA ATDC yields a 1.56% (absolute value) improvement in ITEn over the baseline condition. Raising the PCP limits from 20 MPa to 25 MPa requires increasing the compression ratio to 21.92, boost pressure to 308 kPa, and delaying the intake valve closing timing to −88.7 °CA ATDC, which results in an absolute improvement of 0.86% in ITEn. Baseline engine configuration is updated accordingly to validate the thermal efficiency improvement strategy at a 25 MPa PCP limitation. Experimental results demonstrate a 2.2% (absolute value) improvement in brake thermal efficiency and 1.98% (absolute value) improvement in overall energy efficiency

Effects of Connection Type between Surface Vessel and Submersible Propeller on Motion Performance of Wave Glider

Wave Glider is an autonomous surface vehicle that directly uses wave energy to generate forward power and has been widely used in marine survey and observation. Wave Glider is composed of surface vessel, submersible propeller and the connection structure between them. Connection types are thought to be related to the performance of Wave Glider closely. In this paper, the effects of the connection structure between the surface vessel and the submersible propeller on the motion performance of the Wave Glider are studied. Several connection types such as rigid rod, cable, multi-link chain and elastic rod are applied to connect the surface vessel and the submersible propeller. The models of connection structures are developed respectively. Among them, cable model is established with a finite number of small cylinders, which connected by spring and damping elements; multi-link chain can be seen as hinged by multiple rigid rods; elastic rod model can be looked on as several segments linked with elastic components. Considering the connection characteristics, the integrated dynamic models are established by applying multi-body dynamics software ADAMS (Automatic Dynamic Analysis of Mechanical Systems) with consideration of the hydrodynamic forces on different components of Wave Glider. The propulsion performance of the Wave Glider is calculated by using numerical method, and the simulation results showed that the difference of propulsion performance with different connection types of the Wave Glider is slightly. But serious impacts can occur on the connections of rigid rod and multi-link chain. They can lead to serious extra load on the structure of Wave Glider. From the engineering practice of Wave Glider application, the cable connection is more convenient to transport, deploy, recover and store. It is also the generous connection type for wave glider

Design of a New Propulsion Mechanism of Imitating Duck’s Webbed-feet

With the wide application of the underwater vehicle in ocean exploration, bionics propulsion aroused intensive interest among researchers. Bionic locomotion of aquatic animals has the advantages of highly maneuver, power-efficient endurance and so on. In the paper the mechanism of duck’s swimming is studied and a novel bionics propulsion mechanism is designed and analyzed. The mechanics of underwater vehicle is investigated by ADAMS. Dynamics response of the system is analyzed by using numerical method. The simulation results suggest that the designed propulsion mechanism can imitate the movement modes of the duck’s webbed feet, and implement the motion of vehicle in fluid environment. DOI: http://dx.doi.org/10.11591/telkomnika.v11i8.313

Applicability of Sun’s Empirical Relations for Non-Uniform Sediment in Jiaojiang Estuaries, Zhejiang, China

The numerical simulation of non-uniform sediment transport under tidal flow in estuaries is a complicated, yet important, issue in Zhejiang estuaries. In this paper, a depth-averaged two-dimensional (2D) mathematical model for non-uniform sediment transport in estuaries is established and applied in Zhejiang tidal estuaries based on several newly derived formulas by Zhlin Sun et al. The model is validated using data from several experiments, including an aggradation test and an erosion test. Good performance in the tests indicates that the present model can simulate aggradation and erosion processes of non-uniform sediment. The model is also verified by observational data from the Jiaojiang estuary, and calculations agree well with measurements. The model is thus adaptable to simulating flow and non-uniform sediment transport in tidal estuaries