10,057 research outputs found
Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target?
The Notch signaling pathway regulates important cellular processes involved in stem cell maintenance, proliferation, development, survival, and inflammation. These responses to Notch signaling involving both canonical and non-canonical pathways can be spatially and temporally variable and are highly cell-type dependent. Notch signaling can elicit opposite effects in regulating tumorigenicity (tumor-promoting versus tumor-suppressing function) as well as controlling immune cell responses. In various cancer types, Notch signaling elicits a “cancer stem cell (CSC)” phenotype that results in decreased proliferation, but resistance to various therapies, hence potentially contributing to cell dormancy and relapse. CSCs can reshape their niche by releasing paracrine factors and inflammatory cytokines, and the niche in return can support their quiescence and resistance to therapies as well as the immune response. Moreover, Notch signaling is one of the key regulators of hematopoiesis, immune cell differentiation, and inflammation and is implicated in various autoimmune diseases, carcinogenesis (leukemia), and tumor-induced immunosuppression. Notch can control the fate of various T cell types, including Th1, Th2, and the regulatory T cells (Tregs), and myeloid cells including macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSCs). Both MDSCs and Tregs play an important role in supporting tumor cells (and CSCs) and in evading the immune response. In this review, we will discuss how Notch signaling regulates multiple aspects of the tumor-promoting environment by elucidating its role in CSCs, hematopoiesis, normal immune cell differentiation, and subsequently in tumor-supporting immunogenicity
Nonlocal Gate Of Quantum Network Via Cavity Quantum Electrodynamics
We propose an experimentally feasible scheme to realize the nonlocal gate
between two different quantum network nodes. With an entanglement-qubit (ebit)
acts as a quantum channel, our scheme is resistive to actual environment noise
and can get high fidelity in current cavity quantum electrodynamics (C-QED)
system.Comment: 5 pages, 3 figures, 1 tabl
Enhanced Superconductivity by Rare-earth Metal-doping in Phenanthrene
We successfully synthesized La- and Sm-doped phenanthrene powder samples and
discovered superconductivity at around 6 K in them. The s are 6.1 K for LaPhenanthrene and 6.0 K for SmPhenanthrene, which are
enhanced by about 1 K and 0.5 K compared to those in Phenanthrene (=K
and Rb) and in Phenanthrene ( = Sr and Ba) superconductors
respectively. The superconductive shielding fractions for LaPhenanthrene and
SmPhenanthrene are 46.1%%^{3+}T_cT_{\rm c}^{-1}^{-1}A_3AAe_{1.5}Ae$ = Sr and Ba) superconductors.Comment: 5 pages, 5 figure
The prevalence of insomnia in the general population in China: A meta-analysis
This is the first meta-analysis of the pooled prevalence of insomnia in the general population of China. A systematic literature search was conducted via the following databases: PubMed, PsycINFO, EMBASE and Chinese databases (China National Knowledge Interne (CNKI), WanFang Data and SinoMed). Statistical analyses were performed using the Comprehensive Meta-Analysis program. A total of 17 studies with 115,988 participants met the inclusion criteria for the analysis. The pooled prevalence of insomnia in China was 15.0% (95% Confidence interval [CI]: 12.1%-18.5%). No significant difference was found in the prevalence between genders or across time period. The pooled prevalence of insomnia in population with a mean age of 43.7 years and older (11.6%; 95% CI: 7.5%-17.6%) was significantly lower than in those with a mean age younger than 43.7 years (20.4%; 95% CI: 14.2%-28.2%). The prevalence of insomnia was significantly affected by the type of assessment tools (Q = 14.1, P = 0.001). The general population prevalence of insomnia in China is lower than those reported in Western countries but similar to those in Asian countries. Younger Chinese adults appear to suffer from more insomnia than older adults
- …