5,913 research outputs found
ResumeNet: A Learning-based Framework for Automatic Resume Quality Assessment
Recruitment of appropriate people for certain positions is critical for any
companies or organizations. Manually screening to select appropriate candidates
from large amounts of resumes can be exhausted and time-consuming. However,
there is no public tool that can be directly used for automatic resume quality
assessment (RQA). This motivates us to develop a method for automatic RQA.
Since there is also no public dataset for model training and evaluation, we
build a dataset for RQA by collecting around 10K resumes, which are provided by
a private resume management company. By investigating the dataset, we identify
some factors or features that could be useful to discriminate good resumes from
bad ones, e.g., the consistency between different parts of a resume. Then a
neural-network model is designed to predict the quality of each resume, where
some text processing techniques are incorporated. To deal with the label
deficiency issue in the dataset, we propose several variants of the model by
either utilizing the pair/triplet-based loss, or introducing some
semi-supervised learning technique to make use of the abundant unlabeled data.
Both the presented baseline model and its variants are general and easy to
implement. Various popular criteria including the receiver operating
characteristic (ROC) curve, F-measure and ranking-based average precision (AP)
are adopted for model evaluation. We compare the different variants with our
baseline model. Since there is no public algorithm for RQA, we further compare
our results with those obtained from a website that can score a resume.
Experimental results in terms of different criteria demonstrate the
effectiveness of the proposed method. We foresee that our approach would
transform the way of future human resources management.Comment: ICD
No More Freeways: Urban Land Use-Transportation Dynamics without Freeway Capacity Expansion
Observations of the various limitations of freeway capacity expansion have led to a provocative planning and policy question – What if we completely stop building additional freeway capacity. From a theoretical perspective, as a freeway transportation network matures, there exists a saturation point beyond which any additional freeway capacity would only be counterproductive from a welfare point of view, and worsen the existing urban transportation problems. Traditional benefit/cost analysis of individual freeway capacity expansion projects often ignores long-term induced demand and land use changes and does not represent a systems approach to this important theoretical issue. From a practical perspective, a no-more-freeway policy can relieve transportation funds for other potentially more effective usages, such as improving urban arterial street system, improving transit level of service and coverage, implementing demand management and pricing strategies, and facilitating more efficient land use patterns (e.g. high density in-fill and transit-oriented developments). This research answers the following critical land use-transportation planning questions. Improved knowledge on these issues should benefit planers and decision-makers who pursue mobility and sustainability objectives and have the power to shape future cities.
(1). Under what conditions will freeway capacity expansion become counterproductive to urban planning objectives (where is the saturation point)?
(2). How will land use and transportation evolve under a “No-More-Freeway” policy?
(3). What are the implications of such a policy on congestion, land use efficiency, transportation finance, and social welfare?
(4). What is the impact of a less restrictive “No-More-Freeway” policy that only allows private-section freeway investments and relieves public-section freeway investments for other compelling transportation needs.
The analysis in this project builds upon a modeling tool, ABSOLUTE, developed by the P.I. in previous research projects. ABSOLUTE is an Agent-Based Simulator Of Land Use-Transportation Evolution, which translates planning policies such as the “No-More- Freeway” policy into alternative urban growth paths and possibly urban growth equilibria (land use and transportation system equilibria). Due to the “Small Start” nature of this OTREC project, the analysis focuses primarily on stylized urban areas, and empirical analysis of the “No-More- Freeway” policy is only conducted for one policy scenario on the Twin Cities, MN, area
The Priority of Exploiting Fiscal Revenue or Lessening Public Expenditure: Evidence from China
In the past 28 years, we find that except for the fiscal revenue of 5,132.1 billion yuan in 2007, which is greater than the fiscal expenditure of 4,978.1 billion yuan, presenting a fiscal surplus, the fiscal expenditure of the rest years is greater than the fiscal revenue, showing the situation of public sector net cash requirement (psncr), especially in 2011, the deficit( the gap between fiscal expenditure and fiscal revenue) is 537.3 billion yuan. Since then, the gap between expenditure and revenue has been increasing with each passing year. In 2015, the fiscal deficit is 2,368 billion yuan. In 2018, the fiscal deficit has been expanded to 3,754.4 billion yuan. In order to avoid the continuous increment of the deficit. This paper discusses the causal relationship between China's fiscal revenue and public expenditure from 1990 to 2018. If fiscal revenue has a positive impact on public expenditure, showing that the government shall reduce fiscal deficit through tax increment. On the contrary, it makes public expenditure continue to expand, leading to the continuous deterioration of fiscal deficit, so as to further decide whether China's future fiscal policy should adopt increasing fiscal revenue or deducting public expenditure policy to reduce the deficit
A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines.
BACKGROUND: We previously reported the anti-estrogenic activity of the brown seaweed, Fucus vesiculosus. The present study aimed to further investigate its anti-estrogenic modes of action and to assess other potentially biologically relevant anti-tumorigenic effects in estrogen receptor (ER)-dependent and -independent female cancer cell lines. METHODS: The CALUX® assay was used to determine the effect of a F. vesiculosus extract (FVE) on activation of the ER. Aromatase enzymatic activity was measured to determine the potential effect of FVE on estradiol (E2) biosynthesis. Transcriptional activity profiling of 248 genes involved in cancer, immunity, hormonal regulation, protein phosphorylation, transcription, metabolism, and cellular structure was conducted using the NanoString nCounter® analysis system in FVE-treated breast, ovarian and endometrial cancer cell lines. The effects of FVE on cell viability, morphology, membrane integrity, mitochondrial toxicity, induction of apoptotic and autophagic markers, and cell signaling were also analyzed. RESULTS: In co-treatments with 12.5 pM (EC50) E2, FVE (2 %) reduced ER activation by 50 %, exhibiting potent ER antagonistic effects. FVE inhibited aromatase activity in an in vitro assay (IC50 2.0 %). ER-dependent and -independent cancer cell lines showed significantly decreased viability that correlated with increasing FVE concentrations and altered morphological features suggestive of apoptosis and autophagy. Expression of genes that were significantly altered by FVE (p < 0.05) revealed predominantly apoptotic, autophagic and kinase signaling pathways. FVE also effectively inhibited the phosphorylation of Akt, resulting in reduced mTORC1 activities to stimulate autophagy in cells. Concentration-dependent cleavage of PARP and induction of caspase-3 and -7 activities were observed in MDA-MB-231 cells supporting a role for FVE in the promotion of apoptosis. CONCLUSIONS: Our study provides new insights into the anti-estrogenic activity of F. vesiculosus. Moreover, the induction of autophagy and apoptosis on breast, endometrial and ovarian cancer cell lines suggests additional anti-tumorigenic actions of FVE that are independent of ER status in female cancers
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Bias-free photoelectrochemical water splitting with photosystem II on a dye-sensitized photoanode wired to hydrogenase
Natural photosynthesis stores sunlight in chemical energy carriers, but it has not
evolved for the efficient synthesis of fuels, such as H2. Semi-artificial photosynthesis
combines the strengths of natural photosynthesis with synthetic chemistry and
materials science to develop model systems that overcome Nature’s limitations, such
as low-yielding metabolic pathways and non-complementary light absorption by
Photosystem (PS) I and II. Here, we report a bias-free semi-artificial tandem platform
that wires PSII to hydrogenase for overall water splitting. This photoelectrochemical
cell integrated the red and blue light-absorber PSII with a green light-absorbing
diketopyrrolopyrrole dye-sensitised TiO2 photoanode enabling complementary
panchromatic solar light absorption. Effective electronic communication at the
enzyme-material interface was engineered using an Os complex-modified redox
polymer on a hierarchically-structured TiO2. This system provides a design protocol
for bias-free semi-artificial Z-schemes in vitro and provides an extended toolbox of
biotic and abiotic components to re-engineer photosynthetic pathways.ERC Consolidator Grant, EPSRC (nanoDTC, DTA studentship), Christian Doppler Research Association, OMV Group, Royal Society Newton International Fellowship, Cluster of Excellence RESOLV (DFG) and European Unions' Horizon 202
An epidemiologic study of early biologic effects of benzene in Chinese workers.
Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44 healthy workers currently exposed to benzene (median 8-hr time-weighted average; 31 ppm), and unexposed controls in Shanghai, China. Here we provide an overview of the study results on peripheral blood cells levels and somatic cell mutation frequency measured by the glycophorin A (GPA) gene loss assay and report on peripheral cytokine levels. All peripheral blood cells levels (i.e., total white blood cells, absolute lymphocyte count, platelets, red blood cells, and hemoglobin) were decreased among exposed workers compared to controls, with the exception of the red blood cell mean corpuscular volume, which was higher among exposed subjects. In contrast, peripheral cytokine levels (interleukin-3, interleukin-6, erythropoietin, granulocyte colony-stimulating factor, tissue necrosis factor-alpha) in a subset of the most highly exposed workers (n = 11) were similar to values in controls (n = 11), suggesting that benzene does not affect these growth factor levels in peripheral blood. The GPA assay measures stem cell or precursor erythroid cell mutations expressed in peripheral red blood cells of MN heterozygous subjects, identifying NN variants, which result from loss of the GPA M allele and duplication of the N allele, and N phi variants, which arise from gene inactivation. The NN (but not N phi) GPA variant cell frequency was elevated in the exposed workers compared with controls (mean +/- SD, 13.9 +/- 8.4 mutants per million cells versus 7.4 +/- 5.2 per million cells, (respectively; p = 0.0002), suggesting that benzene produces gene-duplicating but not gene-inactivating mutations at the GPA locus in bone marrow cells of exposed humans. These findings, combined with ongoing analyses of benzene macromolecular adducts and chromosomal aberrations, will provide an opportunity to comprehensively evaluate a wide range of early biologic effects associated with benzene exposure in humans
Removal and fate of micropollutants in a sponge-based moving bed bioreactor
This study investigated the removal of micropollutants using polyurethane sponge as attached-growth carrier. Batch experiments demonstrated that micropollutants could adsorb to non-acclimatized sponge cubes to varying extents. Acclimatized sponge showed significantly enhanced removal of some less hydrophobic compounds (log. D<. 2.5), such as ibuprofen, acetaminophen, naproxen, and estriol, as compared with non-acclimatized sponge. The results for bench-scale sponge-based moving bed bioreactor (MBBR) system elucidated compound-specific variation in removal, ranging from 25.9% (carbamazepine) to 96.8% (β-Estradiol 17-acetate) on average. In the MBBR system, biodegradation served as a major removal pathway for most compounds. However, sorption to sludge phase was also a notable removal mechanism of some persistent micropollutants. Particularly, carbamazepine, ketoprofen and pentachlorophenol were found at high concentrations (7.87, 6.05 and 5.55. μg/g, respectively) on suspended biosolids. As a whole, the effectiveness of MBBR for micropollutant removal was comparable with those of activated sludge processes and MBRs. © 2014 Elsevier Ltd
The Application of the Multiple Points of a Mold Function of UG MoldWizard in the Design of Cutting Compressor
In recent years, mold industry develops rapidly. The design and manufacture of mold have become an important symbol to measure the level of a country#39s manufacturing industry. Difficult point in the design of the cutting compressor for recycling plastic bottles lies in cutting and compressing plastic bottles at the same time. Use UG MoldWizard to design the working process of injection mold. Design and manufacture the U-lower plastic mold with the aid of a computer. Make optimal design plan of the U-lower plastic in the cutting compressor
Effect of hydraulic retention time on the performance of a hybrid moving bed biofilm reactor-membrane bioreactor system for micropollutants removal from municipal wastewater
© 2017 Elsevier Ltd This study evaluated micropollutants removal and membrane fouling behaviour of a hybrid moving bed biofilm reactor-membrane bioreactor (MBBR-MBR) system at four different hydraulic retention times (HRTs) (24, 18, 12 and 6 h). The results revealed that HRT of 18 h was the optimal condition regarding the removal of most selected micropollutants. As the primary removal mechanism in the hybrid system was biodegradation, the attached growth pattern was desirable for enriching slow growing bacteria and developing a diversity of biocoenosis. Thus, the efficient removal of micropollutants was obtained. In terms of membrane fouling propensity analysis, a longer HRT (e.g. HRTs of 24 and 18 h) could significantly mitigate membrane fouling when compared with the shortest HRT of 6 h. Hence, enhanced system performance could be achieved when the MBBR-MBR system was operated at HRT of 18 h
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