Rational design and expeditious synthesis of aromatic cyanodienone derivatives assisted by cyanide-halide exchange

1-n-Butyl-3-methylimidazolium cyanide ([bmim]CN), in the presence of [bmim]Br has been prepared and used for the first time as the medium as well as reagent for the synthesis of aromatic cyanodienones from the corresponding triarylpyrylium perchlorates by cyanide-halide exchange. The [bmim]CN having a reactive anion, accelerated reaction technique without external solvent renders the whole synthesis into a truly ecofriendly protocol. The products is isolated without aqueous work-up in high purity and excellent yield.

Rational design and expeditious synthesis of aromatic cyanodienone derivatives assisted by cyanide-halide exchange

1-n-Butyl-3-methylimidazolium cyanide ([bmim]CN), in the presence of [bmim]Br has been prepared and used for the first time as the medium as well as reagent for the synthesis of aromatic cyanodienones from the corresponding triarylpyrylium perchlorates by cyanide-halide exchange. The [bmim]CN having a reactive anion, is an accelerated reaction technique without external solvent and renders the whole synthesis into a truly eco-friendly protocol. The products can be isolated without aqueous work-up in high purity and excellent yield.

Rational design and expeditious synthesis of aromatic cyanodienone derivatives assisted by cyanide-halide exchange

1027-10301-n-Butyl-3-methylimidazolium cyanide ([bmim]CN), in the presence of [bmim]Br has been prepared and used for thefirst time as the medium as well as reagent for the synthesis of aromatic cyanodienones from the corresponding triarylpyrylium perchlorates by cyanide-halide exchange. The [bmim]CN having a reactive anion, is an accelerated reaction technique without external solvent and renders the whole synthesis into a truly eco-friendly protocol. The products can be isolated without aqueous work-up in high purity and excellent yield

Optimization of Effective Parameters in Fabrication of PVC Flat Sheet Membranes by Response Surface Method for Application in Humic Acid Separation

Hypothesis: Considering water quality problems and strict rules established for drinking water treatment, there is an urgent need to use more effective and economical methods to remove natural organic matter from water. Meanwhile, membrane processes are one of the effective methods to remove these pollutants. In this way, in order to prepare a membrane with a high ability to remove pollutants, in the present study, the production and optimization of poly(vinyl chloride) (PVC) membranes with poly(ethylene glycol) (PEG) additives have been carried out.Methods: PVC microporous membranes were prepared by nonsolvent-induced phase separation method. Influential parameters in the membrane fabrication, including the concentration of PVC and PEG and the composition of the coagulation bath were optimized using the response surface methodology (RSM). Meanwhile, tensile strength and porosity were considered as responses.Findings: The obtained results showed that all the membranes had an asymmetric structure with finger like pores. It was also found that the tensile strength of the membranes increased with the increase in PVC concentration. The lowest tensile strength was related to the membrane made of 10.30% (by wt) of PVC, while the membrane made of 18.7 % (by wt) of PVC had the highest tensile strength. In addition, for the optimum membrane in which the concentration of PVC was 17.52% (by wt), the concentration of PEG was 5.87% (by wt) and the volume fraction of ethanol in the coagulation bath was 0.27, the tensile strength and porosity of the membranes were obtained as 5 MPa and 80.57, respectively. Furthermore, in the following, titanium dioxide nanoparticles (TiO2) were used to prepare the composite membrane under the aforementioned optimum conditions. The obtained results showed that the optimum membrane containing 2% (by wt) of nanoparticles had the highest humic acid separation efficiency with a value of 80%

The Effect of Different Concentrations of Methylprednisolone on Survival, Proliferation, and Migration of Neural Stem/Progenitor Cells

Introduction: The present study addressed whether methylprednisolone (MP) as an anti-inflammatory drug used in neurodegenerative diseases and neural stem/progenitor cells (NS/PCs) is safe.  Methods: First, embryonic rat NS/PCs were exposed to different concentrations of MP, and then we evaluated their survival by MTT assay, proliferation by analyzing the number and diameter of neurospheres, and the migration of the cells by neurosphere assay. Results: The viability of NS/PCs was reduced following exposure to 10, 15, and 20 µg/mL of MP. In addition, although the number of neurospheres did not change, exposure to different concentrations of MP resulted in the formation of smaller neurospheres. Despite these undesirable effects, the highest concentration of MP (20 μg/mL) increased the migration capacity of the NS/PCs. Conclusion: The combination of MP and NS/PCs is not recommended due to the adverse effects of MP on the survival and proliferation of NS/PCs