Effects of Coronal Magnetic Field Configuration on Particle Acceleration and Release during the Ground Level Enhancement Events in Solar Cycle 24

Ground level enhancements (GLEs) are extreme solar energetic particle (SEP) events that are of particular importance in space weather. In solar cycle 24, two GLEs were recorded on 2012 May 17 (GLE 71) and 2017 September 10 (GLE 72), respectively, by a range of advanced modern instruments. Here we conduct a comparative analysis of the two events by focusing on the effects of large-scale magnetic field configuration near active regions on particle acceleration and release. Although the active regions both located near the western limb, temporal variations of SEP intensities and energy spectra measured in-situ display different behaviors at early stages. By combining a potential field model, we find the CME in GLE 71 originated below the streamer belt, while in GLE 72 near the edge of the streamer belt. We reconstruct the CME shock fronts with an ellipsoid model based on nearly simultaneous coronagraph images from multi-viewpoints, and further derive the 3D shock geometry at the GLE onset. The highest-energy particles are primarily accelerated in the shock-streamer interaction regions, i.e., likely at the nose of the shock in GLE 71 and the eastern flank in GLE 72, due to quasi-perpendicular shock geometry and confinement of closed fields. Subsequently, they are released to the field lines connecting to near-Earth spacecraft when the shocks move through the streamer cusp region. This suggests that magnetic structures in the corona, especially shock-streamer interactions, may have played an important role in the acceleration and release of the highest-energy particles in the two events.Comment: Accepted for publication in Ap

Depth-Varying Friction on a Ramp-Flat Fault Illuminated by ∼3-Year InSAR Observations Following the 2017 Mw 7.3 Sarpol-e Zahab Earthquake

We use interferometric synthetic aperture radar observations to investigate the fault geometry and afterslip evolution within 3 years after a mainshock. The postseismic observations favor a ramp-flat structure in which the flat angle should be lower than 10°. The postseismic deformation is dominated by afterslip, while the viscoelastic response is negligible. A multisegment, stress-driven afterslip model (hereafter called the SA-2 model) with depth-varying frictional properties better explains the spatiotemporal evolution of the postseismic deformation than a two-segment, stress-driven afterslip model (hereafter called the SA-1 model). Although the SA-2 model does not improve the misfit significantly, this multisegment fault with depth-varying friction is more physically plausible given the depth-varying mechanical stratigraphy in the region. Compared to the kinematic afterslip model, the mechanical afterslip models with friction variation tend to underestimate early postseismic deformation to the west, which may indicate more complex fault friction than we expected. Both the kinematic and stress-driven models can resolve downdip afterslip, although it could be affected by data noise and model resolution. The transition depth of the sedimentary cover basement interface inferred by afterslip models is ∼12 km in the seismogenic zone, which coincides with the regional stratigraphic profile. Because the coseismic rupture propagated along a basement-involved fault while the postseismic slip may activate the frontal structures and/or shallower detachments in the sedimentary cover, the 2017 Sarpol-e Zahab earthquake may have acted as a typical event that contributed to both thick- and thin-skinned shortening of the Zagros in both seismic and aseismic ways

Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer

Pancreatic cancer (PCC) is a common malignant tumor of the digestive system that is resistant to traditional treatments and has an overall 5-year survival rate of <7%. Transcriptomics research provides reliable biomarkers for diagnosis, prognosis, and clinical precision treatment, as well as the identification of molecular targets for the development of drugs to improve patient survival. We sought to identify new biomarkers for PCC by combining transcriptomics and clinical data with current knowledge regarding molecular mechanisms. Consequently, we employed weighted gene co-expression network analysis and differentially expressed gene analysis to evaluate genes co-expressed in tumor versus normal tissues using pancreatic adenocarcinoma data from The Cancer Genome Atlas and dataset GSE16515 from the Gene Expression Omnibus. Twenty-one overlapping genes were identified, with enrichment of key Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways, including epidermal growth factor receptor signaling, cadherin, cell adhesion, ubiquinone, and glycosphingolipid biosynthesis pathways, and retinol metabolism. Protein-protein interaction analysis highlighted 10 hub genes, according to Maximal Clique Centrality. Univariate and multivariate COX analyses indicated that TSPAN1 serves as an independent prognostic factor for PCC patients. Survival analysis distinguished TSPAN1 as an independent prognostic factor among hub genes in PCC. Finally, immunohistochemical staining results suggested that the TSPAN1 protein levels in the Human Protein Atlas were significantly higher in tumor tissue than in normal tissue. Therefore, TSPAN1 may be involved in PCC development and act as a critical biomarker for diagnosing and predicting PCC patient survival

Ramp-Flat and Splay Faulting Illuminated by Frictional Afterslip Following the 2017 Mw 7.3 Sarpol-e Zahab Earthquake

&lt;p&gt;The postseismic InSAR data used in the manuscript &quot;Frictional Afterslip along a Complex Fault Structure Following the 2017 Mw 7.3 Sarpol-e Zahab Earthquake Revealed by InSAR and 2-D Finite Element Models&quot;.&lt;/p&gt

A brief investigation of the dose field virtual simulation tools for reactor decommissioning and preliminary design for the HWRR reactor in China

The calculation and visualization of the dose field in the decommissioning of nuclear facilities is one of the important functions of the decommissioning virtual simulation system. The dose field simulation tools can provide radiation field distribution and play an important role in determining the decommissioning plan and protecting personnel during the engineering implementation process. This article investigates the development of dose field calculation and visualization in the reactor decommissioning virtual simulation systems. A preliminary technology plan suitable for the development of the decommissioning dose field calculation and visualization display programs of the first Heavy Water Research Reactor (HWRR) in China is proposed. The applicability of the selected scheme is analyzed. The functional requirement and development direction of the HWRR reactor decommissioning dose field tool are preliminarily determined. Furthermore, the reactor vessel of HWRR reactor is modeled, the dose field distribution is calculated and visualized based on the preliminary decommissioning code. This research can provide technical support for the development of the decommissioning simulation system for the first HWRR reactor in China

A brief investigation of the dose field virtual simulation tools for reactor decommissioning and preliminary design for the HWRR reactor in China

The calculation and visualization of the dose field in the decommissioning of nuclear facilities is one of the important functions of the decommissioning virtual simulation system. The dose field simulation tools can provide radiation field distribution and play an important role in determining the decommissioning plan and protecting personnel during the engineering implementation process. This article investigates the development of dose field calculation and visualization in the reactor decommissioning virtual simulation systems. A preliminary technology plan suitable for the development of the decommissioning dose field calculation and visualization display programs of the first Heavy Water Research Reactor (HWRR) in China is proposed. The applicability of the selected scheme is analyzed. The functional requirement and development direction of the HWRR reactor decommissioning dose field tool are preliminarily determined. Furthermore, the reactor vessel of HWRR reactor is modeled, the dose field distribution is calculated and visualized based on the preliminary decommissioning code. This research can provide technical support for the development of the decommissioning simulation system for the first HWRR reactor in China

Fault Slip Model of the 2018 Mw 6.6 Hokkaido Eastern Iburi, Japan, Earthquake Estimated from Satellite Radar and GPS Measurements

In this study, Sentinel-1 and Advanced Land Observation Satellite-2 (ALOS-2) interferometric synthetic aperture radar (InSAR) and global positioning system (GPS) data were used to jointly determine the source parameters and fault slip distribution of the Mw 6.6 Hokkaido eastern Iburi, Japan, earthquake that occurred on 5 September 2018. The coseismic deformation map obtained from the ascending and descending Sentinel-1 and ALOS-2 InSAR data and GPS data is consistent with a thrust faulting event. A comparison between the InSAR-observed and GPS-projected line-of-sight (LOS) deformation suggests that descending Sentinel-1 track T046D, descending ALOS-2 track P018D, and ascending ALOS-2 track P112A and GPS data can be used to invert for the source parameters. The results of a nonlinear inversion show that the seismogenic fault is a blind NNW-trending (strike angle ~347.2&deg;), east-dipping (dip angle ~79.6&deg;) thrust fault. On the basis of the optimal fault geometry model, the fault slip distribution jointly inverted from the three datasets reveals that a significant slip area extends 30 km along the strike and 25 km in the downdip direction, and the peak slip magnitude can approach 0.53 m at a depth of 15.5 km. The estimated geodetic moment magnitude released by the distributed slip model is 6.16 &nbsp; &times; 10 18 &nbsp; N &middot; m , equivalent to an event magnitude of Mw 6.50, which is slightly smaller than the estimates of focal mechanism solutions. According to the Coulomb stress change at the surrounding faults, more attention should be paid to potential earthquake disasters in this region in the near future. In consideration of the possibility of multi-fault rupture and complexity of regional geologic framework, the refined distributed slip and seismogenic mechanism of this deep reverse faulting should be investigated with multi-disciplinary (e.g., geodetic, seismic, and geological) data in further studies

RUNX3 Inhibits the Invasion and Metastasis of Human Colon Cancer HT-29 Cells by Upregulating MMP-2/9

Objective. To investigate the effect of Runt-associated transcription factor 3 (RUNX3) on the invasion and metastasis of human colon cancer HT-29 cells and to preliminarily explore the mechanism of its anticancer effect. Methods. The RUNX3 plasmid vector was transfected into human colon cancer HT-29 cells by liposome-mediated transfection, while the empty vector and the blank group were used as the control group. After Geneticin (G418) screening, HT-29 cells with stable expression of RUNX3 gene were obtained. The expressions of mRNA and proteins of RUNX3 and metalloproteinases (MMP)-2/9 were detected by reverse transcription-polymerase chain reaction (RT-PCR) and western blot. Cell proliferation was determined by MTT assay. The effect of RUNX3 on invasion and metastasis of HT-29 cells was evaluated by scratch injury assay, Transwell chamber, and Matrigel invasion model. Results. RUNX3 was expressed stably in HT-29 cells after transfection. The expressions of RUNX3 mRNA and proteins in the experimental group were significantly higher than those in the blank/empty vector groups. Meanwhile, the expressions of MMP-2/9 mRNA and proteins in the observation group were significantly lower than those in the blank group and the empty vector group. The proliferation and migration ability in the experimental group was significantly lower than blank/empty vector groups from the third day. Transwell chamber experiment and Matrigel invasion assay showed that the number of Transwell cells was decreased significantly than blank/empty vector groups, but no difference was found between the blank group and the empty vector group. Conclusion. RUNX3 can inhibit the invasion and metastasis of human colon cancer HT-29 cells, and the mechanism may be related to decreased expression of MMP-2 and MMP-9