1 research outputs found
Biological Performance of Hexadeca-Substituted Metal Phthalocyanine/Reduced Graphene Oxide Nanobioagents
This study presents a tetra-substituted phthalonitrile
derivative,
namely, diethyl 2-(3,4-dicyano-2,5-bis(hexyloxy)-6-(4-(trifluoromethoxy)phenoxy)phenyl)malonate
(a), cyclotetramerizing in the presence of some metal
salts. The resultant hexadeca-substituted metal phthalocyanines [M=
Co, Zn, InCl)] (b–d) were used for
the modification of reduced graphene oxide for the first time. The
effect of the phthalonitrile/metal phthalocyanines on biological features
of reduced graphene oxide (rGO) was extensively examined by the investigation
of antioxidant, antimicrobial, DNA cleavage, cell viability, and antibiofilm
activities of nanobioagents (1–4).
The results were compared with those of unmodified rGO (nanobioagent 5), as well. Modification of reduced graphene oxide with the
synthesized compounds improved its antioxidant activity. The antioxidant
activities of all the tested nanobioagents also enhanced as the concentration
increased. The antibacterial activities of all the nanobioagents improved
by applying the photodynamic therapeutic (PDT) method. All the phthalonitrile/phthalocyanine-based
nanobioagents (especially phthalocyanine-based nanocomposites) exhibited
DNA cleavage activities, and complete DNA fragmentation was observed
for nanobioagents (1–4) at 200 mg/L.
They can be used as potent antimicrobial and antimicrobial photodynamic
therapy agents as well as Escherichia coli microbial cell inhibitors. As a result, the prepared nanocomposites
can be considered promising candidates for biomedicine