Praeorbulina-like specimens" in sediments of the Northern Arabian Sea during the last glacial period

Date du colloque : 06/2009International audienc

Palaeoclimatology and palaeohydrography of the glacial stages on Celtic and Armorican margins over the last 360 000 yrs

Core MD03-2692 was retrieved in a water-depth of 4064 m on the Celtic margin (Bay of Biscay) during the SEDICAR cruise onboard the RV Marion Dufresne II. It covers the last 360 ka in a total length of 39 m. Multidisciplinary analyses have been applied to this sequence with the aim of studying the palaeoclimatic and palaeoenvironmental signals of the last few climatic cycles. The analyses undertaken include: (1) non-destructive logging with: physical properties (magnetic susceptibility, sediment colour), X-ray radiography and measurement of the major elements by X-ray-fluorescence, (2) analyses of planktonic and benthic foraminifera, lithic grains and stable isotopic measurements (oxygen and carbon). We have focused on the long-term evolution of glacial stages (with special attention to terminations and Heinrich events). The results obtained confirm the close correlation between deep-sea sedimentation recorded on the Celtic margin and changes in the terrestrial environment of the adjacent continent. Heinrich layers have been identified in MIS 2, 3, 6 and 8. We note the occurrence of laminated facies within deglacial sequences deposited during Termination I and MIS 6. These facies are closely linked to disintegration phases of the British–Irish Ice Sheet (BIS). The laminations contain lower ice-rafted detritus (IRD) concentrations than the equivalent Heinrich layers and are linked to abrupt changes in sea-surface palaeotemperatures. We suggest that the laminations are formed by an annual cycle of meltwater and iceberg release from the disintegrating BIS generating cascading plumes of dense turbid meltwater coeval with IRD release

Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis

AbstractThis article contains data related to the research article entitled “Expression of FBN1 during adipogenesis: relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions” [1]. The article concerns the expression of FBN1, the gene encoding the extracellular matrix protein fibrillin-1, during adipogenesis in vitro and in relation to adipose tissue in vivo. The encoded protein has recently been shown to produce a short glucogenic peptide hormone, (Romere et al., 2016) [2], and this gene is therefore a key gene for regulating blood glucose levels. FBN1 and coexpressed genes were examined in mouse strains and in human cells undergoing adipogenesis. The data show the genes that were coexpressed with FBN1, including genes coding for other connective tissue proteins and the proteases that modify them and for the transcription factors that control their expression. Data analysed were derived from datasets available in the public domain and the analysis highlights the utility of such datasets for ongoing analysis and hence reduction in the use of experimental animals

Mass wasting processes along the Owen Ridge (Northwest Indian Ocean)

International audienceThe Owen Ridge is a prominent relief that runs parallel to the coast of Oman in the NW Indian Ocean and is closely linked to the Owen Fracture Zone, an 800-km- long active fault system that accommodates today the Arabia-India strike-slip motion. Several types of mass failures mobilizing the pelagic cover have been mapped in details along the ridge using multibeam bathymetry and sediment echosounder. Here we present a synthetic map of the different types of mass wasting features observed along the ridge and we further establish a morphometric analysis of submarine landslides. The spatial variation of failure morphology is strongly related to the topography of the basement. The highest volumes of multi-events generated slides are mobilized along the southern portion of the ridge. There, the estimated volume of evacuated material during a slide is up to 45 km3. Combining these new observations with re-interpreted ODP seismic lines (Leg 117) documents sporadic mass wasting events through time along the southern segment of the ridge since its uplift in the Early Miocene, with a typical recurrence rate of the order of 105-106 years. Although seismicity may still be the final triggering process, mass wasting frequency is mainly controlled by the slow pelagic sedimentation rates and hence, time needed to build up the 40-80 m thick pelagic cover required to return to a mechanically unstable pelagic cover

Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes

<p>Abstract</p> <p>Background</p> <p>Multipotent stem cells exist within adipose tissue throughout life. An abnormal recruitment of these adipose precursor cells could participate to hyperplasia of adipose tissue observed in severe obesity or to hypoplasia of adipose tissue observed in lipodystrophy. Therefore, pharmacological molecules that control the pool of stem cells in adipose tissue are of great interest. Glycogen Synthase Kinase (GSK) 3 has been previously described as involved in differentiation of preadipose cells and might be a potential therapeutic target to modulate proliferation and differentiation of adipocyte precursors. However, the impact of GSK3 inhibition on human adipose-derived stem cells remained to be investigated. The aim of this study was to investigate GSK3 as a possible target for pharmacological inhibition of stem cell adipogenesis. To reach this goal, we studied the effects of pharmacological inhibitors of GSK3, i.e. lithium chloride (LiCl) and BIO on proliferation and adipocyte differentiation of multipotent stem cells derived from human adipose tissue.</p> <p>Results</p> <p>Our results showed that GSK3 inhibitors inhibited proliferation and clonogenicity of human stem cells, strongly suggesting that GSK3 inhibitors could be potent regulators of the pool of adipocyte precursors in adipose tissue. The impact of GSK3 inhibition on differentiation of hMADS cells was also investigated. Adipogenic and osteogenic differentiations were inhibited upon hMADS treatment with BIO. Whereas a chronic treatment was required to inhibit osteogenesis, a treatment that was strictly restricted to the early step of differentiation was sufficient to inhibit adipogenesis.</p> <p>Conclusion</p> <p>These results demonstrated the feasibility of a pharmacological approach to regulate adipose-derived stem cell function and that GSK3 could represent a potential target for controlling adipocyte precursor pool under conditions where fat tissue formation is impaired.</p

Deglacial laminated facies on the NW European continental margin: The hydrographic significance of British-Irish Ice Sheet deglaciation and Fleuve Manche paleoriver discharges

[1] We have compiled results obtained from four high sedimentation rate hemipelagic sequences from the Celtic sector of the NW European margin ( NE Atlantic) to investigate the paleoceanographic and paleoclimatic evolution of the area over the last few climatic cycles. We focus on periods characteristic of deglacial transitions. We adopt a multiproxy sedimentological, geochemical, and micropaleontological approach, applying a sampling resolution down to ten microns for specific intervals. The investigation demonstrates the relationships between the Bay of Biscay hydrography and the glacial/deglacial history of both the proximal British-Irish Ice Sheet (BIIS) and the western European continent. We identify recurrent phases of laminae deposition concurrent with major BIIS deglacial episodes in all the studied cores. Evidence for abrupt freshwater discharges into the open ocean highlights the influence of such events at a regional scale. We discuss their impact at a global scale considering the present and past key location of the Bay of Biscay versus the Atlantic Meridional Overturning Circulation (AMOC)