Uterine Prolapse during Pregnancy: a Case Report

Background: Pelvic organ prolapse is a common gynecologic condition in women that rarely occur in pregnancy and can complicate the pregnancy. A woman with prolapsed uterus in second trimester of pregnancy and her follow up are presented here.Case Report: A 35-years old G2P1 woman with history of last normal pregnancy and successful vaginal delivery attended to emergency ward of hospital. She was in 14th week of pregnancy and had complain of acute urinary retention and vaginal bulge. She successfully is managed by application of pessary till an uneventful normal vaginal delivery.Conclusion: Management of pelvic organ prolapse during pregnancy is based on patient symptoms. Application of pessary is treatment of choice in such patients. They need to regular follow up during pregnancy in order to control pessary and monitor the pregnancy complications.

A Bibliometric Analysis and Visualization of the Scientific Publications of Universities: A Study of Hamadan University of Medical Sciences during 1992-2018

The evaluation of universities from different perspectives is important for their scientific development. Analyzing the scientific papers of a university under the bibliometric approach is one main evaluative approach. The aim of this study was to conduct a bibliometric analysis and visualization of papers published by Hamadan University of Medical Science (HUMS), Iran, during 1992-2018. This study used bibliometric and visualization techniques. Scopus database was used for data collection. 3753 papers were retrieved by applying Affiliation Search in Scopus advanced search section. Excel and VOSviewer software packages were used for data analysis and bibliometric indicator extraction. An increasing trend was seen in the numbers of HUMS's published papers and received citations. The highest rate of collaboration in national level was with Tehran University of Medical Sciences. Internationally, HUMS's researchers had the highest collaboration with the authors from the United States, the United Kingdom and Switzerland, respectively. All highly-cited papers were published in high level Q1 journals. Term clustering demonstrated four main clusters: epidemiological studies, laboratory studies, pharmacological studies, and microbiological studies. The results of this study can be beneficial to the policy-makers of this university. In addition, researchers and bibliometricians can use this study as a pattern for studying and visualizing the bibliometric indicators of other universities and research institutions

Twin in compared with singleton pregnancies complicated by Preterm premature rupture of membranes (PPROM)

Background: Our purpose was to compare the latency periods of preterm premature rupture of the membranes (PPROM) in twin compared with singleton pregnancies from 24 to 34 weeks' gestation and assessment of respiratory distress syndrome (RDS) between twins and singletons. Materials and Methods: Between 2010 and 2014 in Mahdieh Hospital, Tehran, Iran, data on all women with singleton and twin gestations complicated by PPROM were reviewed. Latencies between singleton and twin pregnancies were compared. An additional comparing according to PPROM at under, equal and above 30 weeks' gestation was surveyed in these groups. In addition, their latencies compared among them. Use of surfactant consumption and need for intubation were measured during hospitalization between twins and singletons. Results: The mean latencies of singleton and twin pregnancies were statistically significant without comparing the gestational age at PPROM (8.22±7.4 vs. 5.54±3.36 days, p=0.001). When PPROM occurred at < 30 weeks' gestation, latency in twins was not statistically significant (8.24±9.81 vs. 8.24±4.71 days, p=0.07) but at > or = 30 weeks' gestation, latency was significantly different in singleton and twin pregnancies (6.3±5.85 vs. 2.42±2.60 days, p=0.002). There were significant differences in the use of surfactant and intubation between twin and singletons (p<0.05). Conclusion: This study provides the basis for effective patient counseling and managing pregnancies with PPROM. Overall, in pregnancies with PPROM at > or = 30 weeks' gestation, latency in twins was significantly shorter than in singleton pregnancies. For fetal lung maturity, the use of surfactant and intubation increased in twins compared with singletons

The Online Attention to Otorhinolaryngology Research: An Altmetric Analysis (1967-2021)

Background: As a new approach and complementary to traditional bibliometrics, altmetrics measures the influence of scientific research in social media tools and applications. Aim: This study aimed at comprehensively analyzing research output in otorhinolaryngology research from its beginning in 1967 to 2021. Methods: Using Scimago Journal Ranking (SJR), 107 otorhinolaryngology journals were retrieved. Of them, 84 journals with their 89044 papers as well as their altmetric scores were extracted from the Altmetric Explorer in 28 February 2022. The citation rates of the top ten papers having high altmetric scores were retrieved from Google Scholar, Scopus, Web of Science and Dimensions. Data were analyzed in excel. Results: 67,529 otorhinolaryngology papers (75%) were mentioned 2,901,187 times in 17 different social media tools. The highest altmetric score of papers amounted to 3,989. The top-ranked media were Nendeley and Twitter, respectively. The USA was the first ranked country in Twitter and Facebook and the UK was such in News Outlet and Policy. The highest mentioned journal was JAMA Otolaryngology–Head & Neck Surgery. The top affiliation in sharing papers was Harvard University with 1621 shared papers. All of the top 10 papers in altmetric scores were multi-authored original research articles.. Conclusion: As one of the first altmetric studies in otorhinolaryngology field, this study provided helpful information for potential authors, researchers, research institutes and journals in the field in increasing the reach and influence of their researches

Co-authorship Networks of Iranian Researchers' Publications on the Field of Management during a Half-Century (1969-2018)

As one of the main bibliometric concepts, co-authorship has been thoughtfully considered in recent years. Despite many bibliometric studies on the co-authorship in different scientific fields and worldwide countries/regions, Iranian researchers' collaboration in the management field has not been studied. This study aimed to investigate the co-authorship networks in the management papers contributed by Iranian researchers indexed in the Web of Science (WoS) during the recent half-century (years, 1969-2018). Bibliometric data on 5414 papers were extracted from WoS and analyzed in Excel, UCINET, and VOSviewer to measure bibliometric indicators, the map needed co-authorship networks, and depict time-based maps and keyword clustering. Findings showed that co-authored papers increased from two items in 1973 to 721 items in 2018. Expert Systems with Applications, African Journal of Business Management, and International Journal of Production Research were ranked first to third in co-authored papers. Top 20 authors published about 17% of papers (946). Islamic Azad University, University of Tehran, and the Amirkabir University of Technology ranked first to third. Most co-authorship frequencies were made from 2012 to 2014. The first to third ranks of collaborating countries were the USA, Canada, and England. Six main keyword clusters were formed, including main topics in the field. In conclusion, Iranian researchers increasingly co-authored in management, especially during the last decade, and published in various journals that some top ones are prestigious journals. However, some gaps need to be bridged by the low contribution of research institutes and universities countrywide and the limited number of authors with high productivity and low collaboration with neighbor countries and influential universities worldwide.https://dorl.net/dor/ 20.1001.1.20088302.2022.20.1.19.

What We Know about Top 1000 Highly-Cited COVID-19 Papers: A Bibliometric Analysis

Background: Highly cited papers are considered publications with a great impact on a scientific community and have been deeply investigated in different fields. Aim: This study aimed at analyzing and visualizing the top 1000 highly cited papers on COVID-19. Methods: As a bibliometric study, this study was conducted by retrieving 1000 highly-cited papers on COVID-19 published during 2019-2021 from Scopus. The search strategy was to obtain 35 related keywords/terms on the COVID-19 as the main term from MeSH and searching them in the fields of paper titles, abstracts, and keywords. Bibliometric techniques such as co-citation analysis, co-authorship analysis and word co-occurrence analysis were used for the study. Data visualization was done by applying the VOSviewer software package and GunnMap. Results: China, the United States of America (USA), and the United Kingdom (UK) with publishing 418, 353, and 149, mostly cited papers were ranked first-to-third, respectively. The top contributing research institutes were from China and the USA. The top three most productive research institutions were Huazhong University of Science and Technology (N=83), Tongji Medical College (N=76), and Wuhan University (N=64), respectively. The New England Journal of Medicine, the Lancet and JAMA ranked first to third in publishing these papers, respectively. Collaborating countries were mainly of European origin. Research institutes from China, the USA, and the UK had higher collaboration. Keyword clustering showed that the clinical features and laboratory descriptions, risk factors, pathogenic and immunological aspects as well as the managerial aspects and urgent preparation of the disease were topics with high concern and concentration. Conclusion: This study is the first bibliometric study on the top 1000 highly cited papers on COVID-19 and can be beneficial to researchers in identifying important topics, active producing agents and existing gaps in the literature on the disease. It can be conceived as a reference for COVID-19 researchers and a guide for conducting other bibliometric studies on COVID-19 scientific investigation

Exploring Global Trends in Otorhinolaryngology Research Output

Background: As an interdisciplinary field, bibliometrics analyses research publications in scientific fields. As a developing medical field, otorhinolaryngology needs to be evaluated from a bibliometric perspective. Aim: This evaluative bibliometric study aimed at analyzing and exploring global research trends in otorhinolaryngology from the beginning to year 2021. Methods: All papers published in otorhinolaryngology field that indexed in Web of Science (WoS) from 1976-2021 were extracted for analysis by conducting a certain search strategy in advanced search section within category of otorhinolaryngology in the WoS. Data were analyzed by Excel and VOSviewer for measuring bibliometric indicators and depicting visualization maps. Results: 217,027 papers were published during the studied time span. The papers increased from two items in the beginning in 1976 to 9,759 items in 2021. USA ranked first with publishing 75,742 papers, followed by Germany with 17,718 papers and England with 14,244 papers. League of European Research Universities (LERU) ranked first among research institutes with publishing 6,517 papers. In journals, Laryngoscope ranked first with publishing 17,891 papers, followed by Otolaryngology-Head and Neck Surgery with 14,340 papers and Journal of Laryngology and Otology with 11,219 papers. The majority of papers were in English (n=199,069; %91,725) and original articles (n=167,724; %77.28). After otorhinolaryngology as the first-ranked area with full coverage, surgery (n=37,586) and audiology speech language pathology (n=22,136) ranked second and third, respectively. 10 highly-occurred keywords were surgery (110), management (94), children (83), quality of life (81), squamous-cell carcinoma (78), cancer (75), head (73), radiotherapy (69), cochlear implant and noise (58) and experience (53), respectively. Co-citation clustering showed Journal of the Acoustical Society of America, Laryngoscope, Otolaryngology–Head and Neck Surgery and Journal of Allergy and Clinical Immunology as the top cited sources. Conclusion: This study is the first to give a comprehensive bibliometric analysis and visualization of global research publication in otorhinolaryngology. It recognized important and influential papers, journals, authors, research institutions, countries and topic areas as well as main considerable keywords and subject clusters and cited sources

Expression of Integrin β1, Focal Adhesion Kinase, and PDZ-Binding Motif in Human Liver Cirrhosis and Simple Steatosis

Background: Integrins are transmembrane mechanosensitive proteins that negatively contribute to the pathogenesis of different types of chronic liver disease and can activate focal adhesion kinase (FAK). Objectives: This study aimed to determine the hepatic integrin β1 and FAK mRNA as well as the transcriptional coactivator with PDZ-binding motif (TAZ) protein expressions in cirrhotic patients and simple steatosis. Methods: In this case–control study, liver tissues were collected from 30 cirrhotic patients with various etiologies (i.e., nonalcoholic steatohepatitis-, primary sclerosing cholangitis-, alcoholic-, autoimmune hepatitis [AIH]- and hepatitis B virus [HBV]/hepatitis C virus [HCV]-related cirrhosis [six per group]), liver samples with simple steatosis (n=6), and control liver tissues (n=9). Results: Integrin β1 gene expression was significantly up-regulated in all cirrhotic groups compared to control group (P<0.05), with the exception of AIH cirrhosis. However, hepatic FAK gene expression and TAZ protein level in the cirrhotic groups were not significantly different than those in the control group. Furthermore, hepatic integrin β1 and FAK gene expressions as well as TAZ protein level in simple steatosis were significantly lower than those in nonalcoholic steatohepatitis (NASH) cirrhosis and control (P<0.05). Conclusion: Integrin β1 was up-regulated in cirrhotic liver tissues. In addition, FAK, integrin β1, and TAZ were concordantly down-regulated in simple steatosis, and may have been involve in the steatosis development

Urtica dioica attenuate effect of Doxorobicin-Induced changes on sperm parameters in the mice

Doxorubicin (DXR) is used as an antitumor agent for the treatment of human neoplasm. The use of DXR has adverse effect on reproductive system including testicular toxicity and alteration in semen quality. The aim of this study was to evaluate the protective effects of Urtica dioica against Doxorobicin-Induced changes on sperm parameters. 24 male mice were randomly divided into 4 groups. Control group received normal saline solution throughout the course of the study. Urtica dioica (UD) control group, received UD (100 mg/kg body weight) thrice in a week and DOX (3 mg/kg body weight) once in a week injected intraperitoneally in Doxorubicin (DXR) control group and Urtica dioica-Doxorubicin (UD-DXR) group, received Urtica dioica (100 mg/kg body weight) three times in a week and DOX (3 mg/kg body weight) once in a week through the route for a period of 2 weeks. At the end of experimental period, all animal were sacrificed by cervical dislocation, their epididymes were removed and sperm analysis were done. In mice with DXR administration, epididymal sperm motility, progressive motility, sperm count and viability significantly decrease while sperm cells with abnormal morphology significantly increase when compared with control groups. Co-treatment with UD attenuate toxicity effect of DXR and improve sperm parameters. Results of our study showed that UD diminished DXR-induced testicular toxicity and improve semen parameters, thus suggesting its co-administration as a protective agent during doxorubicin treatment. Further studies should be aimed to determine protective effect of UD against chemotherapeutic agents such as DXR

Female Obesity and Clinical Outcomes of Assisted Reproductive Technologies (ART): an Updated Systematic Review and Meta-analysis

Assisted Reproductive Technology (ART) has been developed to be used for reproductive-age women with primary and secondary infertilities. Obesity is a worldwide epidemic for both women and men and a major global health concern. The direct effect of Body Mass Index (BMI) increase on the outcomes of ART is still unclear. This study aimed to carry out a systematic review of the available scientific evidence to assess the effects of obesity on the clinical outcome of ART treatment. Numerous studies have shown failure in ART due to increased BMIs in infertile women; however, the impact of increased BMI on clinical effectiveness of ART still remains inconclusive. Using results from 44 studies (831616 subjects) we conducted an updated systematic review and meta-analysis to highlight this subject (clinical pregnancy rate, miscarriage rate and live-birth rate). Compared to the women with BMIs of 25 kg/m(2) or less, women with BMI >= 25 kg/m(2) have a lower chance of pregnancy risk ratio 0.91, 95% CI: 0.89-0.94] as well as lower live-birth rates risk ratio 0.81, 95% CI: 0.70-0.94], and show increased miscarriage rates risk ratio 1.35, 95% CI: 1.28-1.46]. Our findings indicate that elevated BMI and obesity requires more recognition as a potential contributor to negative pregnancy outcomes and reduced live-birth following ART. The results of our meta-analysis suggest that weight loss should be considered in overweight and obese women before the initiation of infertility treatment