Impact Assessment of Orography on the Extreme Precipitation Event of July 2010 over Pakistan: A Numerical Study

The topography influences monsoon precipitation and gives rise to significant rainfall events in South Asia. The physical mechanism involved in such events includes mechanical uplifting, thermodynamics, small scale cloud processes, and large scale atmospheric circulations. The investigation into orographic precipitation is pursued by synoptic and model analysis. Deep convection occurs as warm moist airflow is channeling over steep mountains. WRF model coupled with Morrison double moment scheme is used to assess the relative impact of topography on extreme rainfall event of 26–30 July 2010 in Pakistan. Two sensitivity tests with full topography (CTL) and reduced topography by 50% (LOW) are carried out. Two distinct precipitation zones over Hindukush and Himalaya mountains are identified. The topographic changes significantly affect moisture divergence and spatial and temporal distribution of precipitation. A low level jet is created on windward side of big mountains, yielding enhanced moisture flux and instability. Eddy kinetic energy significantly changes with orographic height. Energy flux created further unstabilized atmosphere and deep convection, producing wide spread heavy rainfall in the area in Himalaya foothills. Under the set synoptic conditions, orographic orientation enhanced the moisture accumulation and deep convection, resulting in occurrence of this extreme event

Isolation and identification of phosphate solubilizer Azospirillum, Bacillus and Enterobacter strains by 16SrRNA sequence analysis and their effect on growth of wheat (Triticum aestivum L.)

The aim of the present study was to isolate phosphate solubilizing bacteria from wheat rhizosphere and investigate their potential for plant growth promotion. Three phosphate solubilizing bacterial strains were isolated by serial dilution method from the rhizosphere of wheat grown under wheat-cotton and wheat-rice crop rotation. 16S rRNA gene sequence of the isolates WS-1, T-34 and T-41 showed 98% similarity to those of Azospirillum, Bacillus and Enterobacter sequences in NCBI data base, respectively. The bacterial strain WS-1 clustered with Azospirillum brasilense strains in the phylogenetic tree constructed using NCBI data base sequences of the genus Azospirillum. The bacterial isolate T-34 formed cluster with Bacillus licheniformis strains in the phylogenetic tree constructed using 16S rRNA sequences of the genera Bacillus and Paenibacillus. In the phylogenetic tree constructed using 16S rRNA gene sequences of genus Enterobacter, the isolate T-41 clustered with Enterobacter amnigenus strains. Phosphate solubilizing activity of the bacterial strains in Pikovskaya medium was investigated by molybdate blue color method using spectrophotometer while organic acids produced in the medium were detected on HPLC. In a growth medium containing insoluble tri-calcium phosphate and supplemented with sucrose, maltose, glucose or galactose as single C-source, all the three isolates produced organic acids like acetic acid, citric acid and gluconic acid for phosphate solubilization. Among the organic acids detected, acetic acid was produced in highest amounts by all strains tested in the media containing different sugars. Maximum acetic acid (56.7 mug/ml) was produced by Bacillus strain T-34 in medium supplemented with sucrose and citric acid (36.2 mug/ml) by the same strain on glucose supplemented medium. Oxalic acid was produced by Bacillus strain T-34 (2.89 mug/ml) and Enterobacter strain T-41 (5.93 mug/ml) only in the medium containing galactose as C-source. Maximum amount of gluconic acid (25.4 mug/ml) was produced by Azospirillum strain WS-1 in the medium containing glucose as C-source. Highest P solubilization activity (298.3 mug/ml) was observed in Bacillus strain T-34 grown on sucrose supplemented medium. Maximum P solubilization was detected in Enterobacter strain T-41 (292.2 mug/ml) in medium containing maltose. Azospirillum strain WS-1 showed maximum P solubilization (218.1 mug/ml) in medium containing glucose as single C-source. All the three bacterial strains produced growth hormone IAA in the growth medium supplemented with tryptophan. Quantification on HPLC indicated maximum IAA production (31.15 mug/ml) by Bacillus strain T-34. A pot experiment conducted to study the effect of bacterial isolates on growth of wheat showed that inoculation with Azospirillum, Bacillus and Enterobacter strains increased the grain yield of wheat by 9.3%, 14.8%, 13.1%, respectively over non-inoculated control. Under field conditions, increase in grain yield of plants inoculated with Azospirillum, Bacillus and Enterobacter was 11.2%, 15.7% and 5.6%, respectively compared with non-inoculated plants.These results indicated that bacterial isolates having plant-beneficial traits like phosphate solubilization and IAA production and capable of improving growth of wheat when used as inoculants qualify for production of biofertilizer for wheat cro

Islamic Monetary Economics: Insights from the Literature

This chapter reviews critical early literature of Islamic monetary economics. The prohibition of Riba has imposed challenges on Islamic economists to come up with the viable alternatives to achieve Islamic monetary policy goals. Our extensive review of theoretical and empirical literature indicates that equity based profit- and loss-sharing instruments have been proposed for conducting open market operations in an interest-free economy. Theoretically, the central bank can achieve desired goals by controlling money supply and profit-sharing ratios. The findings from empirical literature suggest that money demand tend to be more stable in an interest-free economy. Whether monetary transmission works through Islamic banking channel is controversial, but the literature is growing. These findings are not surprising as majority Muslim countries lack sustainable and equitable economic growth. Moreover, these countries suffer from higher inflation and unemployment with little or no monetary freedom due to fixed exchange rate regime, shallow financial markets and strict capital control

Burden of waterpipe smoking and chewing tobacco use among women of reproductive age group using data from the 2012-13 Pakistan Demographic and Health Survey

Background: Despite the general decline in cigarette smoking, use of alternative forms of tobacco has increased particularly in developing countries. Waterpipe (WP) and Chewing Tobacco (CT) are two such alternative forms, finding their way into many populations. However, the burden of these alternative forms of tobacco and their socio demographic determinants are still unclear. We assessed the prevalence of WP and CT use among women of reproductive age group in Pakistan. Methods: Data from the most recent Pakistan Demographic and Health Survey 2012–13 (n = 13,558) was used for this analysis. Information obtained from ever married women, aged between 15 and 49 years were analyzed using two separate data subgroups; exclusive WP smokers (total n = 12,995) and exclusive CT users (total n = 12,771). Univariate and Multivariate logistic regression analyses were conducted and results were reported as crude and adjusted Odds Ratio with 95 % confidence intervals. Results: Prevalence of WP smoking and CT were 4 % and 2 %, respectively. After multivariate adjustments, ever married women who were: older than 35 years (OR; 4.68 95 % CI, 2.62–8.37), were poorest (OR = 4.03, 95 % CI 2.08–7.81), and had no education (OR = 9.19, 95 % CI 5.10–16.54), were more likely to be WP smokers. Similarly, ever married women who were: older than 35 years (OR = 3.19, 95 % CI 1.69–6.00), had no education (OR = 4.94, 95 % CI 2.62–9.33), were poor (OR = 1.64, 95 % CI 1.07–2.48) and had visited health facility in last 12 months (OR = 1.81, 95 % CI 1.22–2.70) were more likely to be CT users as well. Conclusion: Older women with lower socio-economic profile were more likely to use WP and CT. Focused policies aiming towards reducing the burden of alternate forms of tobacco use among women is urgently needed to control the tobacco epidemic in the country

The state of ambient air quality in Pakistan—a review

Background and purpose: Pakistan, during the last decade, has seen an extensive escalation in population growth, urbanization, and industrialization, together with a great increase in motorization and energy use. As a result, a substantial rise has taken place in the types and number of emission sources of various air pollutants. However, due to the lack of air quality management capabilities, the country is suffering from deterioration of air quality. Evidence from various governmental organizations and international bodies has indicated that air pollution is a significant risk to the environment, quality of life, and health of the population. The Government has taken positive steps toward air quality management in the form of the Pakistan Clean Air Program and has recently established a small number of continuous monitoring stations. However, ambient air quality standards have not yet been established. This paper reviews the data being available on the criteria air pollutants: particulate matter (PM), sulfur dioxide, ozone, carbon monoxide, nitrogen dioxide, and lead. Methods: Air pollution studies in Pakistan published in both scientific journals and by the Government have been reviewed and the reported concentrations of PM, SO2, O3, CO, NO2, and Pb collated. A comparison of the levels of these air pollutants with the World Health Organization air quality guidelines was carried out. Results: Particulate matter was the most serious air pollutant in the country. NO2 has emerged as the second high-risk pollutant. The reported levels of PM, SO2, CO, NO2, and Pb were many times higher than the World Health Organization air quality guidelines. Only O3 concentrations were below the guidelines. Conclusions: The current state of air quality calls for immediate action to tackle the poor air quality. The establishment of ambient air quality standards, an extension of the continuous monitoring sites, and the development of emission control strategies are essential. © Springer-Verlag 2009

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019 : a systematic analysis for the Global Burden of Disease Study 2020, Release 1

Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabilities. Drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020, Release 1, we did a systematic analysis of global, regional, and national vaccine coverage trends using a statistical framework, by vaccine and over time. Methods For this analysis we collated 55 326 country-specific, cohort-specific, year-specific, vaccine-specific, and dosespecific observations of routine childhood vaccination coverage between 1980 and 2019. Using spatiotemporal Gaussian process regression, we produced location-specific and year-specific estimates of 11 routine childhood vaccine coverage indicators for 204 countries and territories from 1980 to 2019, adjusting for biases in countryreported data and reflecting reported stockouts and supply disruptions. We analysed global and regional trends in coverage and numbers of zero-dose children (defined as those who never received a diphtheria-tetanus-pertussis [DTP] vaccine dose), progress towards GVAP targets, and the relationship between vaccine coverage and sociodemographic development. Findings By 2019, global coverage of third-dose DTP (DTP3; 81.6% [95% uncertainty interval 80.4-82 .7]) more than doubled from levels estimated in 1980 (39.9% [37.5-42.1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38.5% [35.4-41.3] in 1980 to 83.6% [82.3-84.8] in 2019). Third- dose polio vaccine (Pol3) coverage also increased, from 42.6% (41.4-44.1) in 1980 to 79.8% (78.4-81.1) in 2019, and global coverage of newer vaccines increased rapidly between 2000 and 2019. The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56.8 million (52.6-60. 9) to 14.5 million (13.4-15.9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. Only 11 countries and territories were estimated to have reached the national GVAP target of at least 90% coverage for all assessed vaccines in 2019. Interpretation After achieving large gains in childhood vaccine coverage worldwide, in much of the world this progress was stalled or reversed from 2010 to 2019. These findings underscore the importance of revisiting routine immunisation strategies and programmatic approaches, recentring service delivery around equity and underserved populations. Strengthening vaccine data and monitoring systems is crucial to these pursuits, now and through to 2030, to ensure that all children have access to, and can benefit from, lifesaving vaccines. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Smart city big data analytics: An advanced review

© 2019 Wiley Periodicals, Inc. With the increasing role of ICT in enabling and supporting smart cities, the demand for big data analytics solutions is increasing. Various artificial intelligence, data mining, machine learning and statistical analysis-based solutions have been successfully applied in thematic domains like climate science, energy management, transport, air quality management and weather pattern analysis. In this paper, we present a systematic review of the literature on smart city big data analytics. We have searched a number of different repositories using specific keywords and followed a structured data mining methodology for selecting material for the review. We have also performed a technological and thematic analysis of the shortlisted literature, identified various data mining/machine learning techniques and presented the results. Based on this analysis we also present a classification model that studies four aspects of research in this domain. These include data models, computing models, security and privacy aspects and major market drivers in the smart cities domain. Moreover, we present a gap analysis and identify future directions for research. For the thematic analysis we identified the themes smart city governance, economy, environment, transport and energy. We present the major challenges in these themes, the major research work done in the field of data analytics to address these challenges and future research directions. This article is categorized under: Application Areas > Government and Public Sector Fundamental Concepts of Data and Knowledge > Big Data Mining

ECMO for Critically Ill COVID-19 with ARDS: A Case Series

Introduction Veno-venous extracorporeal membrane oxygenation (VV-ECMO) as bridge to recovery in critically ill COVID-19 continues to be commonly utilized strategy in cases with persistent respiratory failure refractory to traditional ventilation support Case Report We report 5 cases of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV-2) who were treated with ECMO (Table 1). All 5 cases presented with fever, cough and shortness of breath and a positive nasopharyngeal swab for SARS-CoV-2 on admission. Case 1, 2, 3 and 5 patients were hypoxemic with saturation less than 90% on admission and decompensated rapidly, whereas Case 4 decompensated after day 14. Mechanical ventilation failed to provide adequate oxygenation in all 5 cases; case 2,3 and 5 were started on recruitment measures with proning while it was not possible for case 1 owing to morbid obesity. Proning was not possible in the case 4 as patient became severely hypoxemic while patient was undergoing mechanical thrombectomy. The case 1-4 remained on ECMO for 19, 17, 17 and 2 days respectively. All except case 2 had improvement in APACHEII and SOFA score after ECMO initiation. All 5 patients had elevated inflammatory markers of serum ferritin, D-dimer, Lactate dehydrogenase (LDH), C-reactive protein (CRP) which trended down after a few days of ECMO initiation All 5 patients received high dose steroids during their stay in the ICU. Case 4 and 5 passed away after compassionate extubation. Case 1-3 had prolonged hospital course with complication of hospital acquired pneumonia requiring multiple courses of broad-spectrum antibiotics. Summary Our observational report of 5 patients reports the use of ECMO in critically ill SARS-CoV-2 with ARDS and difficult to maintain saturation despite mechanical ventilation and proning with recovery for 3 patients. However, given the lack of ECMO centers; this is not a readily available option. Further studies are warranted to investigate the role of ECMO in SARRS-CoV-2 and careful identification of appropriate candidates