885 research outputs found
Beam-beam simulation code BBSIM for particle accelerators
A highly efficient, fully parallelized, six-dimensional tracking model for
simulating interactions of colliding hadron beams in high energy ring colliders
and simulating schemes for mitigating their effects is described. The model
uses the weak-strong approximation for calculating the head-on interactions
when the test beam has lower intensity than the other beam, a look-up table for
the efficient calculation of long-range beam-beam forces, and a self-consistent
Poisson solver when both beams have comparable intensities. A performance test
of the model in a parallel environment is presented. The code is used to
calculate beam emittance and beam loss in the Tevatron at Fermilab and compared
with measurements. We also present results from the studies of two schemes
proposed to compensate the beam-beam interactions: a) the compensation of
long-range interactions in the Relativistic Heavy Ion Collider (RHIC) at
Brookhaven and the Large Hadron Collider (LHC) at CERN with a current-carrying
wire, b) the use of a low energy electron beam to compensate the head-on
interactions in RHIC
The Frequency Dependence of Critical-velocity Behavior in Oscillatory Flow of Superfluid Helium-4 Through a 2-micrometer by 2-micrometer Aperture in a Thin Foil
The critical-velocity behavior of oscillatory superfluid Helium-4 flow
through a 2-micrometer by 2-micrometer aperture in a 0.1-micrometer-thick foil
has been studied from 0.36 K to 2.10 K at frequencies from less than 50 Hz up
to above 1880 Hz. The pressure remained less than 0.5 bar. In early runs during
which the frequency remained below 400 Hz, the critical velocity was a
nearly-linearly decreasing function of increasing temperature throughout the
region of temperature studied. In runs at the lowest frequencies, isolated 2 Pi
phase slips could be observed at the onset of dissipation. In runs with
frequencies higher than 400 Hz, downward curvature was observed in the decrease
of critical velocity with increasing temperature. In addition, above 500 Hz an
alteration in supercritical behavior was seen at the lower temperatures,
involving the appearance of large energy-loss events. These irregular events
typically lasted a few tens of half-cycles of oscillation and could involve
hundreds of times more energy loss than would have occurred in a single
complete 2 Pi phase slip at maximum flow. The temperatures at which this
altered behavior was observed rose with frequency, from ~ 0.6 K and below, at
500 Hz, to ~ 1.0 K and below, at 1880 Hz.Comment: 35 pages, 13 figures, prequel to cond-mat/050203
Holons on a meandering stripe: quantum numbers
We attempt to access the regime of strong coupling between charge carriers
and transverse dynamics of an isolated conducting ``stripe'', such as those
found in cuprate superconductors. A stripe is modeled as a partially doped
domain wall in an antiferromagnet (AF), introduced in the context of two
different models: the t-J model with strong Ising anisotropy, and the Hubbard
model in the Hartree-Fock approximation. The domain walls with a given linear
charge density are supported artificially by boundary conditions. In both
models we find a regime of parameters where doped holes lose their spin and
become holons (charge Q=1, spin S_z=0), which can move along the stripe without
frustrating AF environment. One aspect in which the holons on the AF domain
wall differ from those in an ordinary one-dimensional electron gas is their
transverse degree of freedom: a mobile holon always resides on a transverse
kink (or antikink) of the domain wall. This gives rise to two holon flavors and
to a strong coupling between doped charges and transverse fluctuations of a
stripe.Comment: Minor revisions: references update
Krueppel-like factor 15 regulates Wnt/beta-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart
Wnt/beta-catenin signalling controls adult heart remodelling in part via regulation of cardiac progenitor cell (CPC) differentiation. An enhanced understanding of mechanisms controlling CPC biology might facilitate the development of new therapeutic strategies in heart failure. We identified and characterized a novel cardiac interaction between Krueppel-like factor 15 and components of the Wnt/beta-catenin pathway leading to inhibition of transcription. In vitro mutation, reporter assays and co-localization analyses revealed that KLF15 requires both the C-terminus, necessary for nuclear localization, and a minimal N-terminal regulatory region to inhibit transcription. In line with this, functional Klf15 knock-out mice exhibited cardiac beta-catenin transcriptional activation along with functional cardiac deterioration in normal homeostasis and upon hypertrophy. We further provide in vivo and in vitro evidences for preferential endothelial lineage differentiation of CPCs upon KLF15 deletion. Via inhibition of beta-catenin transcription, KLF15 controls CPC homeostasis in the adult heart similar to embryonic cardiogenesis. This knowledge may provide a tool for reactivation of this apparently dormant CPC population in the adult heart and thus be an attractive approach to enhance endogenous cardiac repair
Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment
Objectives:
This study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) ≤0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR).
Background:
FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR.
Methods:
We recruited patients undergoing routine FFR assessment and made paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, cFFR, and FFR). Contrast medium and dose were per local practice, as was the dose of intracoronary adenosine. Operators were encouraged to perform both intracoronary and intravenous adenosine assessments and a final drift check to assess wire calibration. A central core lab analyzed blinded pressure tracings in a standardized fashion.
Results:
A total of 763 subjects were enrolled from 12 international centers. Contrast volume was 8 ± 2 ml per measurement, and 8 different contrast media were used. Repeated measurements of each metric showed a bias <0.005, but a lower SD (less variability) for cFFR than resting indexes. Although Pd/Pa and iFR demonstrated equivalent performance against FFR ≤0.8 (78.5% vs. 79.9% accuracy; p = 0.78; area under the receiver-operating characteristic curve: 0.875 vs. 0.881; p = 0.35), cFFR improved both metrics (85.8% accuracy and 0.930 area; p < 0.001 for each) with an optimal binary threshold of 0.83. A hybrid decision-making strategy using cFFR required adenosine less often than when based on either Pd/Pa or iFR.
Conclusions:
cFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only ∼85% agreement
The KASCADE-Grande Experiment and the LOPES Project
KASCADE-Grande is the extension of the multi-detector setup KASCADE to cover
a primary cosmic ray energy range from 100 TeV to 1 EeV. The enlarged EAS
experiment provides comprehensive observations of cosmic rays in the energy
region around the knee. Grande is an array of 700 x 700 sqm equipped with 37
plastic scintillator stations sensitive to measure energy deposits and arrival
times of air shower particles. LOPES is a small radio antenna array to operate
in conjunction with KASCADE-Grande in order to calibrate the radio emission
from cosmic ray air showers. Status and capabilities of the KASCADE-Grande
experiment and the LOPES project are presented.Comment: To appear in Nuclear Physics B, Proceedings Supplements, as part of
the volume for the CRIS 2004, Cosmic Ray International Seminar: GZK and
Surrounding
Comparison of different diastolic resting indexes to iFR: are they all equal?
Background:
Pressure measurement for the duration of the wave-free period (WFP) is considered essential for resting-state physiological assessment of coronary stenosis severity using the instantaneous wave-free ratio (iFR).
Objectives:
The aim of this study was to compare other diastolic resting indexes to iFR.
Methods:
In the population of the VERIFY2 (Pd/Pa vs iFR in an Unselected Population Referred for Invasive Angiography) study, iFR calculated by proprietary software (Volcano Harvest, Volcano Corporation, Rancho Cordova, California) was compared with the ratio of resting distal coronary pressure and aortic pressure during the complete duration of diastole (dPR), 25% to 75% of diastole (dPR25–75), and midpoint of diastole (dPRmid), along with Matlab calculated iFR (iFRmatlab) and iFR-like indexes shortening the length of the WFP by 50 and 100 ms (iFR−50ms and iFR−100ms), respectively. Mutual differences, Spearman correlations, area under the curve values from receiver-operating characteristic analyses, and diagnostic performance with respect to iFR and fractional flow reserve (FFR) were calculated for all indexes.
Results:
Median iFR in 197 patients with 257 vessels was 0.91 with an interquartile range of 0.87 to 0.95. The mutual differences (± SD) with iFR were 0.006 ± 0.011 (dPR), 0.001 ± 0.007 (dPR25–75), 0.001 ± 0.008 (dPRmid), 0.005 ± 0.009 (iFRmatlab), 0.003 ± 0.008 (iFR−50ms), and 0.001 ± 0.009 (iFR−100ms). Correlations for all indexes with iFR were >0.99 (p < 0.001 for all). Area under the curve values for predicting iFR were >0.99 for all indexes as well. Diagnostic accuracy compared with FFR was 76% to 77% for all indexes including iFR.
Conclusions:
All diastolic resting indexes tested were identical to iFR, both numerically and with respect to their agreement with FFR. A numerically equal value to iFR can be determined without restriction to the WFP. Cutoff values, guidelines, and clinical recommendations for iFR can therefore be extended to these other indexes. (Pd/Pa vs iFR in an Unselected Population Referred for Invasive Angiography [VERIFY2]; NCT02377310)
Reasoning on a network of aligned ontologies
zimmermann2008bInternational audienceIn the context of the Semantic Web or semantic peer to peer systems, many ontologies may exist and be developed independently. Ontology alignments help integrating, mediating or reasoning with a system of networked ontologies. Though different formalisms have already been defined to reason with such systems, they do not consider ontology alignments as first class objects designed by third party ontology matching systems. Correspondences between ontologies are often asserted from an external point of view encompassing both ontologies. We study consistency checking in a network of aligned ontologies represented in Integrated Distributed Description Logics (IDDL). This formalism treats local knowledge (ontologies) and global knowledge (inter-ontology semantic relations, i.e., alignments) separately by distinguishing local interpretations and global interpretation so that local systems do not need to directly connect to each other. We consequently devise a correct and complete algorithm which, although being far from tractable, has interesting properties: it is independent from the local logics expressing ontologies by encapsulating local reasoners. This shows that consistency of a IDDL system is decidable whenever consistency of the local logics is decidable. Moreover, the expressiveness of local logics does not need to be known as long as local reasoners can handle at least ALC
Radio detection of cosmic ray air showers with LOPES
In the last few years, radio detection of cosmic ray air showers has
experienced a true renaissance, becoming manifest in a number of new
experiments and simulation efforts. In particular, the LOPES project has
successfully implemented modern interferometric methods to measure the radio
emission from extensive air showers. LOPES has confirmed that the emission is
coherent and of geomagnetic origin, as expected by the geosynchrotron
mechanism, and has demonstrated that a large scale application of the radio
technique has great potential to complement current measurements of ultra-high
energy cosmic rays. We describe the current status, most recent results and
open questions regarding radio detection of cosmic rays and give an overview of
ongoing research and development for an application of the radio technique in
the framework of the Pierre Auger Observatory.Comment: 8 pages; Proceedings of the CRIS2006 conference, Catania, Italy; to
be published in Nuclear Physics B, Proceedings Supplement
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