65 research outputs found
Plasmodium vivax Tryptophan-Rich Antigen PvTRAg33.5 Contains Alpha Helical Structure and Multidomain Architecture
- Author
- A Buschiazzo
- A Krogh
- A Matouschek
- AA Siddiqui
- AA Siddiqui
- AA Yeliseev
- AC Uhlemann
- AG Murzin
- B Ahmad
- B Li
- B Rost
- BR Brooks
- CL King
- D Matulis
- Deepak Kumar
- E Quevillon
- EM Malkin
- F Khan
- F Zsila
- FB Ntumngia
- FB Ntumngia
- G Divita
- Georges Snounou
- H Bannai
- H Curtidor
- H Schulz
- H Xue
- Hema Bora
- IW McNae
- J Shi
- JM Burns
- JM Burns Jr
- K Hofmann
- K Karplus
- K Salzwedel
- K Singh
- KM Pan
- M Gomi
- M Nishio
- M Schiffer
- MA Andrade
- MT Alam
- MT Alam
- NH Tolia
- P Ray
- Priyankar Sen
- Punit Kaur
- R Jalah
- RA Laskowski
- Rizwan Hasan Khan
- RM Bennett-Lovsey
- S Garg
- S Wu
- Sheena Garg
- T Konno
- TL Bailey
- TL Bailey
- V Bhakuni
- WN Grundy
- Y Zhang
- Y Zhang
- Yagya D. Sharma
- YH Chen
- ZH Reed
- Publication venue
- Public Library of Science
- Publication date
- 20/01/2011
- Field of study
Tryptophan-rich proteins from several malarial parasites have been identified where they play an important role in host-parasite interaction. Structural characterization of these proteins is needed to develop them as therapeutic targets. Here, we describe a novel Plasmodium vivax tryptophan-rich protein named PvTRAg33.5. It is expressed by blood stage(s) of the parasite and its gene contains two exons. The exon 1 encodes for a 23 amino acids long putative signal peptide which is likely to be cleaved off whereas the exon 2 encodes for the mature protein of 252 amino acids. The mature protein contains B-cell epitopes which were recognized by the human immune system during P.vivax infection. The PvTRAg33.5 contains 24 (9.5%) tryptophan residues and six motifs whose patterns were similar among tryptophan-rich proteins. The modeled structure of the PvTRAg33.5 consists of a multidomain architecture which is stabilized by the presence of large number of tryptophan residues. The recombinant PvTRAg33.5 showed predominantly α helical structure and alpha helix to beta sheet transition at pH below 4.5. Protein acquires an irreversible non-native state at temperature more than 50°C at neutral pH. Its secondary and tertiary structures remain stable in the presence of 35% alcohol but these structures are destabilized at higher alcohol concentrations due to the disturbance of hydrophobic interactions between tryptophanyl residues. These structural changes in the protein might occur during its translocation to interact with other proteins at its final destination for biological function such as erythrocyte invasion
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
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- Zubikarai G
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Abdallah RI
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- AKI Research Group
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- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
- Faivre V
- Fang M
- Fanzaghi P
- Farias P
- Faulds MC
- Fave G
- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
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- Fernandez R
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- Fernández L
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- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
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- Fiks T
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- Fileković S
- Filho CA
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- FINNRESUSCI Study Group
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- Fleischmann E
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- Frenzel T
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- Frithiof R
- Fritz C
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- Fromentin M
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- Fumagalli F
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- Gabán-Díez Á
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- Gaide-Chevronnay L
- Gainnier M
- Gaite FB
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- Gajic O
- Galache JA
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- Garrido BB
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- Gaspard N
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- Gaudard P
- Gavranovic Z
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- Jardim JJ
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- Lebiedz P
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- Lebut J
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- Maertens B
- Maggiorini M
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- Mirković T
- Mistry M
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- Mlcek M
- Moerer O
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- Peralvo-Bernat M
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- Pinsky M
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- St George’s University of London
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- Winder-Rhodes S
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- Yılmaz G
- Yilmazer F
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- Yoshitake E
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
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- Baili E
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- Balconi A
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- Bankhead-Kendall Brittany K
- Banky B
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- Baptista VH
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- Barlow Emma
- Barod Ravi
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- Baronio G
- Barrat B
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- Bartalucci B
- Bartolini I
- Bashir Y
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- Batstone Martin
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- Beard David
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- Belluco C
- Belvedere A
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- Benkabbou A
- Benson Ruth A
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- Bhangu Aneel A
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- Bhat MA
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- Bisagni P
- Blanco-Colino Ruth
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- Borghi F
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- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
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- Buarque Lima
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- Burke Joshua
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- Bywater Edward
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- Canas-Martinez A
- Canonico G
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- Capolupo GT
- Capunge I
- Caram EL
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- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
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- Tsoulfas Georgios
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- van Ramshorst Gabrielle H
- Varghese Chris
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- Veetil Kannummal S
- Vendrame C
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- Vieira A
- Vieira B
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- Vimalachandran Dale
- Vimalchandra Dale
- Violante T
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- Weitz J
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- Whelan M
- Wilkins Alex
- Willaert W
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- Winter D
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- Wong MP
- Wood M
- Wrigh Naomi
- Wullschleger M
- Xavier R
- Xenaki S
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- Yadev I
- Yang W
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- Yezzaji H
- Yiallourou A
- Yousof EA
- Yunus Mohd MF
- Yurttas C
- Zakaria AD
- Zakaria Z
- Zambon M
- Zanus G
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- Zelic M
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
- Zourntou S
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Chemical Constituents of the Aerial Parts of Kalidium foliatum
- Author
- Baitenov M. S.
- Bina Shaheen Siddiqui
- Gauhar Shahmanovna Burasheva
- Hui W.-H. Li M.-M.
- Karzhaubekova Zh. Zh. Burasheva G.
- Karzhaubekova Zh. Zh. Burasheva G.
- Komarov V. L.
- Meisels A. Ruegg R., Jeger O., Ruz
- Nurgyl Adaibaevna Sultanova
- Oshima Y. Ohsawa T., Hikino H.
- Shamma M. Glick R. E., Mumma R. O.
- Zhanat Zhymabekovna Karzhaubekova
- Publication venue
- 'Pharmaceutical Society of Japan'
- Publication date
- 01/01/2007
- Field of study
Balamuthia mandrillaris meningoencephalitis in an immunocompromised patient
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Remote Antimicrobial Stewardship: A Solution for Meeting The Joint Commission Stewardship Standard?
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Nano silica-bonded N-propylsulfamic acid as an efficient and environmentally benign catalyst for the synthesis of 1,5-benzodiazepines
- Author
- A Gallud
- A Maleki
- A Rabahi
- A Shaabani
- AJ Moro
- AN Bateson
- AP Wight
- B Kaboudin
- B Karimi
- B Narayana
- B Ou
- BM Reddy
- D Dallinger
- F Rashedian
- G Grossi
- G Sabitha
- GB Cassano
- GW Breton
- JS Yadav
- K Niknam
- M Curini
- M Hajjami
- M Nardi
- M Pozarentzi
- MA Pasha
- MA Zolfigol
- MS Balakrishna
- MS Park
- N Ahmed
- R Djudjic
- R Kaoua
- RA Pawar
- S Shylesh
- S Tarannum
- Saima Tarannum
- SG Konda
- SK De
- SP Brojeni
- SR Jetti
- SS Pandit
- V Polshettiwar
- W Li
- W Xie
- X Wei
- XQ Pan
- Zeba N. Siddiqui
- ZH Zhang
- ZN Siddiqui
- ZN Siddiqui
- ZN Siddiqui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synthesis of multilayer polymer-immobilised nanosilver for catalytic study in condensation reaction of aniline and acetylacetone
- Author
- A Biffis
- AD Pomogailo
- AK Zharmagambetova
- AK Zharmagambetova
- AR Gholap
- AY Kim
- B Corain
- B Das
- B Rechsteiner
- B Saha
- BLV Prasad
- CM Cobley
- F Epifano
- G Carotenuto
- H Cong
- HW Zhang
- J Sun
- KM Koczkur
- LP Fu
- M Abass
- M Chtchigrovsky
- M Rai
- M Wilson
- M Xia
- N Ahmed
- ND Eddington
- NM Hemmaragala
- P Centomo
- P Hodge
- Q Li
- R Fišera
- R Si
- R Xu
- R Zhang
- RJ Isaifan
- S Park
- S Porel
- S Zhang
- T Mitsudome
- Y Li
- Z Wang
- ZH Zhang
- ZH Zhang
- ZH Zhang
- ZM Michalska
- ZN Siddiqui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …