Classification analysis on physicochemical properties of coloured and non-coloured waxy rice

Six coloured and six non-coloured waxy rice varieties were analyzed by determining amylose, fat, and protein content, pasting, and thermal properties. Significant differences in protein content as well as pasting properties between coloured and non-coloured waxy rice were identified. It was demonstrated that protein may have a main influence on pasting and thermal properties of waxy rice. In addition, the optimal linear relationship between protein and pasting or thermal properties was found by combining RVA and DSC data using Principal component analysis (PCA). Typical indicators, which can classify coloured and non-coloured waxy rice, could be identified by Hierarchical cluster analysis (HCA). In pasting properties, trough and consistency viscosity were typical indicators; in thermal properties, enthalpy and stop temperature were typical indicators

Aspisol inhibits tumor growth and induces apoptosis in breast cancer

Nonsteroidal anti-inflammatory drugs inhibit cell proliferation and induce apoptosis in various cancer cell lines, which is considered to be an important mechanism for their anti-tumor activity and cancer prevention. However, the molecular mechanisms through which these compounds induce apoptosis are not well understood. Aim: to determine the effects of nonselective cyclooxygenase-2 (COX-2) inhibitor, aspisol on breast cancer cells in vitro and in vivo. Methods: The cytotoxic activity of aspisol was evaluated by MTT assay. The apoptosis index of cells was measured by flow cytometry. Immunohistochemical staining was used to detect expressions of COX-2 and caspase-3 in MDA-MB-231 cells. The expression of bcl-2 and bax was analyzed by Western blot analysis. The content of prostaglandin E2 (PGE2) in MDA-MB-231 cells was estimated by ELISA. In vivo apoptosis of the tumor cells was detected by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). Results: Our results showed that aspisol reduced viability of MDA-MB-231 cells in time- and dose- dependent fashions and induced apoptosis by increase of caspase-3 and bax expressions while decrease of COX-2 and bcl-2 expression in vitro. In addition, exposure to aspisol decreased the basal release of PGE2. In vivo, aspisol also inhibited the proliferation of breast cancer cells and induced their apoptosis. Conclusions: Our in vitro and in vivo data indicated that the antitumor effects of aspisol on breast cancer cells was probably mediated by the induction of apoptosis, and it could be linked to the downregulation of the COX-2 or bcl-2 expression and up-regulation of caspase-3 or bax expression.Нестероидные противовоспалительные препараты ингибируют пролиферацию клеток и вызывают апоптоз во многих опухолевых клеточных линиях, что считается важным механизмом их противоопухолевой активности и профилактики развития рака. Тем не менее молекулярные механизмы апоптотического действия этих препаратов изучены недостаточно. Цель: изучить действие неспецифического ингибитора циклогексиназы-2 (COX-2) — аспизола — на злокачественные клетки рака молочной железы in vitro и in vivo. Методы: выживаемоть клеток MDA-MB-231 определяли с помощью MTT-теста. Апоптотический индекс измеряли с помощью проточной цитометрии и иммуногистохимическим окрашиванием с антителами против COX-2 и каспазы-3. Экспрессию bcl-2 и bax изучали с помощью Вестерн-блот-анализа. Содержание простагландина E2 (PGE2 ) в клетках MDA-MB-231 оценивали методом ELISA. In vivo апоптоз опухолевых клеток определяли путем выявления разрывов ДНК с помощью концевой дезоксинуклеот-идилтранферазы (метод TUNEL). Результаты: показано, что в зависимости от времени инкубации и дозы аспизол угнетал рост клеток MDA-MB-231 in vitro и вызывал их апоптоз на фоне повышения экспрессии каспазы-3 и bax, а также снижения экспрессии COX-2 и bcl-2. В условиях in vivo аспизол также ингибировал пролиферацию злокачественных клеток рака молочной железы и вызывал их апоптоз. Выводы: данные, полученные in vitro и in vivo, свидетельствуют о противоопухолевом эффекте аспизола на клетки рака молочной железы, что скорее всего опосредовано его проапоптотическим действием и может быть связано со снижением экспрессии COX-2 и bcl-2, а также повышением экспрессии каспазы-3 и bax

Influence of casting temperature on the thermal stability of Cu- and Zr-based metallic glasses: theoretical analysis and experiments

Influence of casting temperature on the thermal stability of Cu- and Zr-based metallic glasses (MGs) was analyzed based on the monomer-cluster structural model using the Johnson-Mehl-Avrami (JMA) equation. The result indicates that increasing the casting temperature can enhance the thermal stability of MGs. It is suggested that it be attributed to the decrease in the amount of the local ordering clusters induced by the elevating casting temperature. The prediction is confirmed by continuous heating transformation diagrams constructed for the Cu- and Zr-amorphous samples obtained under different casting temperatures

Low-impulse blast behaviour of fibre-metal laminates

This paper presents three dimensional (3D) finite element (FE) models of the low-impulse localised blast loading response of fibre-metal laminates (FMLs) based on an 2024-O aluminium alloy and a woven glass-fibre/polypropylene composite (GFPP). A vectorized user material subroutine (VUMAT) is developed to define the mechanical constitutive behaviour and Hashin’s 3D failure criteria incorporating strain-rate effects in the GFPP. In order to apply localised blast loading, a user subroutine VDLOAD is used to model the pressure distribution over the exposed area of the plate. These subroutines are implemented into the commercial finite element code ABAQUS/Explicit to model the deformation and failure mechanisms in FMLs. The FE models consider FMLs based on various stacking configurations. Both the transient and permanent displacements of the laminates are investigated. Good correlation is obtained between the measured experimental and numerical displacements, the panel deformations and failure modes. By using the validated models, parametric studies can be carried out to optimise the blast resistance of FMLs based on a range of stacking sequences and layer thicknesses

Spin polarized tunneling in ferromagnet/unconventional superconductor junctions

We study tunneling in ferromagnet/unconventional superconductor (F/S) junctions. We include the effects of spin polarization, interfacial resistance, and Fermi wavevector mismatch (FWM) between the F and S regions. Andreev reflection (AR) at the F/S interface, governing tunneling at low bias voltage, is strongly modified by these parameters. The conductance exhibits a very wide variety of features as a function of applied voltage.Comment: Revision includes new figures with angular averages and correction of minor error

Mapping of periodically poled crystals via spontaneous parametric down-conversion

A new method for characterization of periodically poled crystals is developed based on spontaneous parametric down-conversion. The method is demonstrated on crystals of Y:LiNbO3, Mg:Y:LiNbO3 with non-uniform periodically poled structures, obtained directly under Czochralski growth procedure and designed for application of OPO in the mid infrared range. Infrared dispersion of refractive index, effective working periods and wavelengths of OPO were determined by special treatment of frequency-angular spectra of spontaneous parametric down-conversion in the visible range. Two-dimensional mapping via spontaneous parametric down-conversion is proposed for characterizing spatial distribution of bulk quasi-phase matching efficiency across the input window of a periodically poled sample.Comment: 19 pages, 6 figure

Andreev Reflection in Ferromagnet/Superconductor/Ferromagnet Double Junction Systems

We present a theory of Andreev reflection in a ferromagnet/superconductor/ferromagnet double junction system. The spin polarized quasiparticles penetrate to the superconductor in the range of penetration depth from the interface by the Andreev reflection. When the thickness of the superconductor is comparable to or smaller than the penetration depth, the spin polarized quasiparticles pass through the superconductor and therefore the electric current depends on the relative orientation of magnetizations of the ferromagnets. The dependences of the magnetoresistance on the thickness of the superconductor, temperature, the exchange field of the ferromagnets and the height of the interfacial barriers are analyzed. Our theory explains recent experimental results well.Comment: 8 pages, 9 figures, submitted to Phys. Rev.

Nernst effect of iron pnictide and cuprate superconductors: signatures of spin density wave and stripe order

The Nernst effect has recently proven a sensitive probe for detecting unusual normal state properties of unconventional superconductors. In particular, it may sensitively detect Fermi surface reconstructions which are connected to a charge or spin density wave (SDW) ordered state, and even fluctuating forms of such a state. Here we summarize recent results for the Nernst effect of the iron pnictide superconductor $\rm LaO_{1-x}F_xFeAs$, whose ground state evolves upon doping from an itinerant SDW to a superconducting state, and the cuprate superconductor $\rm La_{1.8-x}Eu_{0.2}Sr_xCuO_4$ which exhibits static stripe order as a ground state competing with the superconductivity. In $\rm LaO_{1-x}F_xFeAs$, the SDW order leads to a huge Nernst response, which allows to detect even fluctuating SDW precursors at superconducting doping levels where long range SDW order is suppressed. This is in contrast to the impact of stripe order on the normal state Nernst effect in $\rm La_{1.8-x}Eu_{0.2}Sr_xCuO_4$. Here, though signatures of the stripe order are detectable in the temperature dependence of the Nernst coefficient, its overall temperature dependence is very similar to that of $\rm La_{2-x}Sr_xCuO_4$, where stripe order is absent. The anomalies which are induced by the stripe order are very subtle and the enhancement of the Nernst response due to static stripe order in $\rm La_{1.8-x}Eu_{0.2}Sr_xCuO_4$ as compared to that of the pseudogap phase in $\rm La_{2-x}Sr_xCuO_4$, if any, is very small.Comment: To appear in: 'Properties and applications of thermoelectric materials - II', V. Zlatic and A. Hewson, editors, Proceedings of NATO Advanced Research Workshop, Hvar, Croatia, September 19 -25, 2011, NATO Science for Peace and Security Series B: Physics and Biophysics, (Springer Science+Business Media B.V. 2012

Spin-Polarized Transport Across an La0.7_{0.7}Sr0.3_{0.3}MnO3_{3}/YBa2_{2}Cu3_{3}O7_{7} Interface: Role of Andreev Bound States

Transport across an La$_{0.7}$Sr$_{0.3}MnO$_{3}/YBa$_{2}Cu$_{3}$O$_{7}$(LSMO/YBCO), interface is studied as a function of temperature and surface morphology. For comparison, control measurements are performed in non-magnetic heterostructures of LaNiO$_{3}$/YBCO and Ag/YBCO. In all cases, YBCO is used as bottom layer to eliminate the channel resistance and to minimize thermal effects. The observed differential conductance re ects the role of Andreev bound states in a-b planes, and brings out for the first time the suppression of such states by the spin-polarized transport across the interface. The theoretical analysis of the measured data reveals decay of the spin polarization near the LSMO surface with temperature, consistent with the reported photoemission data.Comment: 5 pages LaTeX, 3 eps figures included, accepted by Physical Review