Isolation and characterization of 5-hydoxy-4', 7-dimethoxyisoflavone from the root bark of Millettia Mannii (Leguminoceae)

No Abstract. Journal of the Cameroon Academy of Sciences Vol. 5(2&3) 2005: 97-10

Prenylated isoflavanone from the roots of Erythrina sigmoidea

A novel prenylated isoflavanone, sigmoidin I, has been isolated from the roots of Erythrina sigmoidea, in addition to the known isoflavones, corylin and neobavaisoflavone and the known pterocarpan, phaseollidin. Its structure was established as 7,4'-dihydroxy-3'-methoxy-5'-(3-methylbut-2-enyl) isoflavanone by means of spectroscopic analyses and chemical transformations. Neobavaisoflavone displayed antifungal potency in vitro with minimum inhibitory concentrations against Aspergillus fumigatus and Cryptococcus neoformans, of 50 mg ml-1

EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF THE FRUIT-RIND OF PICRALIMA NITIDA (APOCYNACEAE)

The methanol (M) extract of the fruit-rind of Picralima nitida (PN) (Apocynaceae) was tested for its anti-diarrhoeal activity. Like loperamide (3 mg/kg body weight), a single oral dose of PN-M (375, 750 mg/kg body weight) produced a significant decrease in the frequency of defecation and severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit; castor oil-induced intestinal fluid accumulation (enteropooling) and electrolyte concentration in the small intestinal fluid. PN-M produced a decrease in intestinal transit (18.81-21.86%) as compared to castor oil treated animals. Unlike atropine, PN-M significantly inhibited castor oil-induced enteropooling. However it did not alter the electrolyte concentration in intestinal fluid as compared to castor oil treated rats

Evaluation of Antimicrobial Activity of the Stem Bark of Cylicodiscus Gabunensis (Mimosaceae)

Ethyl acetate(EA) extract of the stem bark of Cylicodiscus gabunensis (CG) was analysed phytochemically and evaluated for its antimicrobial activity against 17 pathogenic species isolated from patient: Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, Shigella flexneri, Morganella morganii, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Citrobacter freundii, Enterobacter cloacae, Enterobacter agglomerans, Staphylococcus aureus, Streptococcus feacalis, Pseudomonas aeruginosa, Bacillus cereus T, Candida albicans and Candida glabrata. Flavonoids, saponins, tannins, polyphenols, coumarins, triterpenes and/or sterols and reducing sugars were detected in the (EA) extract of CG. The best MIC and MBC values for the microorganisms sensitive to the extract were 0.00078 and 0.00315 mg/ml respectively. The greater and remarkable antimicrobial activity of the (EA) extract of CG was recorded with Staphylococcus aureus, Proteus vulgaris and Bacillus cereus T. These results provide a rationalization for the traditional use of this plant for the treatment of infections diseases

Evaluation of antimicrobial activity of the fruitrind of Picralima nitida (Aapocynaceae) and the stem bark of Cylicodscus gabunensis (Mimosaceae)

Ethyl acetate(EA) extract of the stem bark of Cylicodiscus gabunensis (CG) and methanol(M) extract of the fruit-rinds of Picralima nitida (PN) were analysed phytochemically and evaluated for their antimicrobial activity against 17 pathogenic species isolated from patient: Escherichia coli, Klebsiella pneumoniae, Shigella dysenteriae, Shigella flexneri, Morganella morganii, Proteus vulgaris, Proteus mirabilis, Salmonella thyphi, Citrobacter freundii, Enterobacter cloacae, Enterobacter agglomerans, Staphylococcus aureus, Streptococcus feacalis, Pseudomonas aeruginosa, Bacillus cereus T, Candida albicans and Candida glabrata. Alkaloids, flavonoids, saponins, polyphenols, cardiac glycoside and glycoside were detected in the (M) extract of PN whereas flavonoids, saponins, tannins, polyphenols, coumarins, triterpenes and/or sterols and reducing sugars were detected in the (EA) extract of CG. The best MIC and MBC values for the microorganisms sensitive to the (EA) extract of CG were 0.00078 and 0.00315mg/ml respectively whereas its were 0.00078 and 0.001525mg/ml respectively to the methanol extract of PN. The greater and remarkable antimicrobial activities of the (EA) extract of CG were recorded with Staphylococcus aureus, Proteus vulgaris and Bacillus cereus T whereas it was recorded with Proteus mirabilis for the (M) extract of PN. These results provide a rationalization for the traditional use of both plants for the treatment of infections diseases. Keywords: Antimicrobial activity, Cylicodiscus gabunensis, Picralima nitida West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 6-1

<b>Antiparasitic prenylated isoflavonoids from seeds of <i>Millettia griffoniana</i></b>

Two new prenylated isoflavonoids, namely 7-methoxyebenosin and griffonianone E along with the known calopogonium isoflavone B and 7,2'-dimethoxy-4',5'-methylenedioxy isoflavone were isolated from the seeds of <i>Millettia griffoniana</i>. Their structures were assigned on the basis of spectroscopic data. The new compounds exhibit moderate trypanocidal and anti-plasmodial activities

Anticoccidial constituents from the stem bark of Turraeanthus africanus

International audienceIn order to study some biological active products, phytochemical investigation of the stem bark of Turraeanthus africanus have led to the isolation of a novel compound 1, a new benzoic acid derivative, named turraeanthin C, and two known compounds sesamin (2) and stigmasterol. The structures of these compounds were established by spectral analysis, including two-dimensional nuclear magnetic resonance. The extract and the isolated compounds 1 and 2 showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals

ANTIPARASITIC PRENYLATED ISOFLAVONOIDS FROM SEEDS OF MILLETTIA GRIFFONIANA

Two new prenylated isoflavonoids, namely 7-methoxyebenosin and griffonianone E along with the known calopogonium isoflavone B and 7,2\'-dimethoxy-4\',5\'-methylenedioxy isoflavone were isolated from the seeds of Millettia griffoniana. Their structures were assigned on the basis of spectroscopic data. The new compounds exhibit moderate trypanocidal and anti-plasmodial activities. KEY WORDS: Millettia griffoniana, Fabaceae, Papilionoideae, Isoflavones, Trypanocidal, Anti-plasmodial Bull. Chem. Soc. Ethiop. 2005, 19(1), 75-80